JNK
Les JNK (c-Jun N-terminal kinases) sont un sous-groupe de la famille MAPK qui répondent aux stimuli de stress, tels que les cytokines, les radiations ultraviolettes et les chocs thermiques, et sont impliqués dans le contrôle de l'apoptose, de l'inflammation et des réponses immunitaires. La signalisation JNK est cruciale pour la régulation des réponses cellulaires au stress et a été impliquée dans diverses maladies, y compris les troubles neurodégénératifs, le cancer et les affections inflammatoires. Chez CymitQuimica, nous offrons une gamme de modulateurs de la voie JNK pour soutenir vos recherches sur la signalisation du stress, l'apoptose et la pathologie des maladies.
Produits appartenant à la catégorie "JNK"
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Pamapimod
CAS :Pamapimod (R1503) (R-1503, Ro4402257) is a novel, selective inhibitor of p38 mitogen-activated protein kinase.Formule :C19H20F2N4O4Degré de pureté :97.63% - 99.99%Couleur et forme :SolidMasse moléculaire :406.38Ref: TM-T6927
1mg56,00€5mg119,00€10mg187,00€25mg378,00€50mg605,00€100mg852,00€500mg1.700,00€1mL*10mM (DMSO)131,00€Taurochenodeoxycholic acid sodium
CAS :Sodium taurochenodeoxycholate: induces apoptosis, anti-inflammatory, boosts insulin, stimulates α2-cells, increases [Ca(2+)](c).Formule :C26H44NNaO6SDegré de pureté :98.23% - 99.45%Couleur et forme :White To Off-White PowderMasse moléculaire :521.68SU3327
CAS :SU3327 (halicin) is a potent, selective and substrate-competitive inhibitor of JNK(IC50 of 0.7 μM).Formule :C5H3N5O2S3Degré de pureté :98.39%Couleur et forme :SolidMasse moléculaire :261.3Sesamolin
CAS :Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.Formule :C20H18O7Degré de pureté :98.77% - 99.04%Couleur et forme :SolidMasse moléculaire :370.35Ref: TM-T5S2283
1mg40,00€5mg85,00€10mg135,00€25mg216,00€50mg324,00€100mg472,00€500mg1.026,00€1mL*10mM (DMSO)88,00€JNK2-IN-1
JNK2-IN-1 (Compound J27), a selective JNK2 inhibitor with a dissociation constant (Kd) of 79.2 µM, exhibits anti-inflammatory effects by attenuating TNF-α andFormule :C30H26N4O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :522.55JNK-1-IN-4
CAS :JNK-1-IN-4 (Compound E1) is an inhibitor of JNK, targeting JNK-1, JNK-2, and JNK-3 with IC50 values of 2.7, 19.0, and 9.0 nM, respectively. This compound inhibits the phosphorylation of c-Jun and reduces the expression of TGF-β1-induced EMT markers (such as fibronectin and α-SMA). JNK-1-IN-4 exhibits favorable pharmacokinetic properties with a bioavailability of 69%. Additionally, it demonstrates antifibrotic effects in a Bleomycin-induced mouse model of idiopathic pulmonary fibrosis.Formule :C22H25BrN6O3Couleur et forme :SolidMasse moléculaire :501.38Polyphyllin I
CAS :Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formule :C44H70O16Degré de pureté :98% - 99.5%Couleur et forme :SolidMasse moléculaire :855.02MAP4K4-IN-6
MAP4K4-IN-6 (Compound 15f) is a MAP4K4 inhibitor with an IC50 of 80 nM. It reduces the phosphorylation of c-Jun and exhibits neuroprotective effects. Additionally, MAP4K4-IN-6 enhances the vitality of motor neurons and can be utilized in the study of amyotrophic lateral sclerosis (ALS).Couleur et forme :Odour SolidLoureirin B
CAS :Loureirin B suppresses fibrosis by modulating MMPs/TIMPs, hindering fibroblast growth, and targeting TGF-β1/Smad2/3 pathway.Formule :C18H20O5Degré de pureté :99.33% - 99.86%Couleur et forme :SolidMasse moléculaire :316.35JNK-IN-12
JNK-IN-12 (compound P2) is a mitochondrial-targeted JNK inhibitor with an IC50 value of 66.3 nM, comprising a mitochondrial-specific cell-penetrating peptideFormule :C56H82N16O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1091.35Tomatidine
CAS :Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.Formule :C27H45NO2Degré de pureté :98.38% - 99.98%Couleur et forme :SolidMasse moléculaire :415.65DB07268
CAS :DB07268 is a potent and selective JNK1 inhibitor.Formule :C17H15N5O2Degré de pureté :98.2% - 98.91%Couleur et forme :SolidMasse moléculaire :321.33OVA-E1 peptide TFA
CAS :OVA-E1 peptide TFA activates the p38 and JNK cascades similarly in mutant and wild-type thymocytes.Formule :C49H77F3N10O16Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1119.19Actein
CAS :Actein stimulates bone formation, counters osteoporosis and oxidative damage, and may treat lipid disorders and cancer, inhibiting breast cancer cell growth.Formule :C37H56O11Degré de pureté :≥98%Couleur et forme :Brown PowderMasse moléculaire :676.83Esculentoside H
CAS :Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Formule :C48H76O21Degré de pureté :98.04% - 99.3%Couleur et forme :SolidMasse moléculaire :989.1AS601245.2TFA (345987-15-7 free base)
CAS :AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3,Formule :C24H18F6N6O4SDegré de pureté :98%Couleur et forme :SoildMasse moléculaire :600.50J30-8
CAS :J30-8 is a JNK3 inhibitor (IC50: 40 nM) with neuroprotective activity and can be used to study neurodegenerative diseases such as Alzheimer's disease.Formule :C17H9ClFN3O2SDegré de pureté :99.90%Couleur et forme :SolidMasse moléculaire :373.79BSJ-04-122
CAS :BSJ-04-122: MKK4/7 inhibitor with IC50s of 4 nM & 181 nM, used in cancer research.Formule :C15H12ClN5ODegré de pureté :97.58%Couleur et forme :SolidMasse moléculaire :313.74JNK-IN-14
JNK-IN-14 is a potent inhibitor of JNK with IC50 values of 1.81 nM for JNK1, 12.7 nM for JNK2, and 10.5 nM for JNK3.Formule :C27H31N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :521.63CC-401 Hydrochloride
CAS :CC-401 Hydrochloride (CC401 HCl) is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with antineoplastic activity.Formule :C22H25ClN6ODegré de pureté :99.53% - ≥95%Couleur et forme :SolidMasse moléculaire :424.93
