Raf
Les kinases Raf sont des composants clés de la voie de signalisation MAPK/ERK, jouant un rôle critique dans la transmission des signaux de la membrane cellulaire au noyau. L'activation de Raf conduit à la phosphorylation de MEK, qui active ensuite ERK, influençant ainsi la division cellulaire, la différenciation et la survie. Les mutations de Raf, en particulier dans B-Raf, sont associées à divers cancers, ce qui fait de Raf une cible cruciale en thérapie anticancéreuse. Chez CymitQuimica, nous offrons une variété d'inhibiteurs et de modulateurs de Raf pour soutenir vos recherches en oncologie, transduction de signaux et développement thérapeutique.
Produits appartenant à la catégorie "Raf"
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RMC-0331
CAS :RMC-0331 (RM-023) is an oral SOS1 inhibitor with potential to block RAS activation and anticancer properties.Formule :C22H25ClF3N5O3Degré de pureté :99.81%Couleur et forme :SolidMasse moléculaire :499.91Ref: TM-T38170
1mg145,00€2mg210,00€5mg354,00€10mg630,00€25mg1.301,00€50mg2.015,00€100mg3.002,00€1mL*10mM (DMSO)378,00€AD80
CAS :AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.Formule :C22H19F4N7ODegré de pureté :100% - 99.49%Couleur et forme :SolidMasse moléculaire :473.43Ref: TM-T4301
1mg47,00€5mg92,00€10mg145,00€25mg283,00€50mg464,00€100mg680,00€500mg1.406,00€1mL*10mM (DMSO)96,00€Raf inhibitor 1
CAS :B-Raf inhibitor 1 (B-Raf inhibitor 1) is a potent and selective B-Raf inhibitor.Formule :C26H19ClN8Degré de pureté :98.05%Couleur et forme :SolidMasse moléculaire :478.94Regorafénib N-oxyde (M2)
CAS :Regorafénib N-oxyde M2 is an active metabolite of Regorafenib.Formule :C21H15ClF4N4O4Degré de pureté :98.03% - 99.48%Couleur et forme :SolidMasse moléculaire :498.81Ref: TM-T10157
1mg44,00€2mg56,00€5mg80,00€10mg103,00€25mg180,00€50mg324,00€100mg472,00€1mL*10mM (DMSO)88,00€NST-628
CAS :NST-628 is a pan-RAF-MEK molecular glue that prevents RAF from phosphorylating and activating MEK. NST-628 inhibits the RAF-MEK signaling complex.Formule :C22H18F2N4O5SDegré de pureté :98.62%Couleur et forme :SolidMasse moléculaire :488.46PLX8394
CAS :Plixorafenib (PLX8394) is an orally active inhibitor of the serine/threonine protein kinase B-Raf (BRAF) protein.Cost-effective and quality-assured.Formule :C25H21F3N6O3SDegré de pureté :100% - 98.22%Couleur et forme :SolidMasse moléculaire :542.53Ref: TM-T3579
2mg42,00€5mg59,00€10mg99,00€25mg165,00€50mg265,00€100mg472,00€200mg687,00€1mL*10mM (DMSO)72,00€CCT196969
CAS :CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.Formule :C27H24FN7O3Degré de pureté :98.58% - 98.93%Couleur et forme :SolidMasse moléculaire :513.52BAY-293
CAS :BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).Formule :C25H28N4O2SDegré de pureté :96.8%Couleur et forme :SolidMasse moléculaire :448.58TAK-580
CAS :TAK-580 (MLN2480) is an oral, selective pan-Raf kinase inhibitor in Clinicalal trials.Formule :C17H12Cl2F3N7O2SDegré de pureté :99.25% - 99.77%Couleur et forme :SolidMasse moléculaire :506.29Ref: TM-T6895
1mg52,00€2mg74,00€5mg103,00€10mg180,00€25mg303,00€50mg445,00€100mg655,00€1mL*10mM (DMSO)116,00€LUT014
CAS :LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.Formule :C27H19F3N8ODegré de pureté :99.03%Couleur et forme :SolidMasse moléculaire :528.49Ref: TM-T15794
1mg66,00€5mg142,00€10mg188,00€25mg346,00€50mg487,00€100mg682,00€1mL*10mM (DMSO)166,00€K-Ras(G12C) Inhibitor 6
CAS :Irreversible K-Ras(G12C) inhibitor 6 fully modifies the protein at 10 μM after 24h in vitro.Formule :C17H22Cl2N2O3SDegré de pureté :89.07% - 97.09%Couleur et forme :SolidMasse moléculaire :405.33Ref: TM-T3725
1mg63,00€2mg88,00€5mg133,00€10mg230,00€25mg477,00€50mg667,00€100mg932,00€1mL*10mM (DMSO)133,00€Dabrafenib Mesylate
CAS :Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).Formule :C24H24F3N5O5S3Degré de pureté :99.45% - 99.62%Couleur et forme :SolidMasse moléculaire :615.67Regorafenib monohydrate
CAS :Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murineFormule :C21H17ClF4N4O4Degré de pureté :99.69%Couleur et forme :SolidMasse moléculaire :500.83Ref: TM-T1792L
5mg35,00€10mg48,00€25mg69,00€50mg88,00€100mg140,00€200mg207,00€500mg348,00€1mL*10mM (DMSO)58,00€K-Ras(G12C) inhibitor 9
CAS :K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).Formule :C16H21ClIN3O4SDegré de pureté :97.33% - 97.45%Couleur et forme :SolidMasse moléculaire :513.78Ref: TM-T6556
1mg52,00€2mg74,00€5mg123,00€10mg183,00€25mg378,00€50mg547,00€100mg750,00€1mL*10mM (DMSO)183,00€Takeda-6d
CAS :Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Formule :C27H19ClFN5O3SDegré de pureté :98.27%Couleur et forme :SolidMasse moléculaire :547.99Ref: TM-T22436
1mg97,00€2mg135,00€5mg188,00€10mg283,00€25mg462,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)255,00€Cyclorasin 9A5 TFA
Cyclorasin 9A5 TFA is a cell-penetrating cyclic peptide consisting of 11 residues that inhibits the interaction between Ras and Raf proteins, with an IC50 of 120 nM.Formule :C75H108FN25O13·xC2HF3O2Couleur et forme :SolidMasse moléculaire :1586.82 (free base)BI-882370
CAS :BI-882370 is a specific RAF kinase inhibitor.Formule :C28H33F2N7O2SDegré de pureté :97.33% - 99.07%Couleur et forme :SolidMasse moléculaire :569.67MEK/RAF-IN-1
MEK/RAF-IN-1 (Compound 16b) serves as an inhibitor targeting both MEK and RAF, demonstrating potent efficacy with IC 50 values reported at 28 nM for MEK1, and 3 nM for both BRAF and BRAFV600E. This compound exhibits significant antitumor capabilities, effectively curbing cell proliferation in vitro in MIA PaCa-2 (G12C KRAS), HCT116 (G13D KRAS), and C26 (G12D KRAS) cells. Furthermore, MEK/RAF-IN-1 significantly restricts tumor growth in xenograft mouse models employed in the study of colorectal cancer.Formule :C28H29F3N6O5SCouleur et forme :SolidMasse moléculaire :618.63KG5
CAS :KG5 inhibits PDGFRβ, B-Raf, FLT3, KIT, c-Raf; has anticancer and antiangiogenic effects; Kd: 520 nM (PDGFRβ), 300 nM (PDGFRα).Formule :C20H16F3N7OSDegré de pureté :98.2%Couleur et forme :SolidMasse moléculaire :459.45Ref: TM-T41003
1mg34,00€2mg47,00€5mg74,00€10mg105,00€25mg205,00€50mg313,00€100mg449,00€200mg628,00€1mL*10mM (DMSO)89,00€LSN3074753
CAS :LSN3074753, a derivative of LY3009120, acts as a pan-RAF and Raf dimer inhibitor. This compound exhibits inhibitory activity against tumor cells driven by either BRAF monomers or RAF dimers, particularly in the activation of the MAPK pathway, including colorectal cancers with BRAF or KRAS mutations. When combined with Cetuximab, LSN3074753 demonstrates additive and synergistic effects in colorectal cancer PDX models, especially in those harboring KRAS or BRAF mutations.Formule :C24H30FN5O2Couleur et forme :SolidMasse moléculaire :439.53
