Hétérocycles azotés (N)

Please enquire for more information about 1H-Pyrrolo[3,2-b]pyridin-5-amine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1H-Pyrrolo[2,3-b]pyridin-4-amine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-Amino-3-(trifluoromethyl)pyridine-5-boronic acid pinacol ester including the price, delivery time and more detailed product information at the technical inquiry form on this page

7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid is a kinase inhibitor that inhibits the cyclin-dependent kinases. It is used in the treatment of breast and lung cancer. 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylicacid has been shown to inhibit the activity of pyrimidine kinases with IC50 values of 0.5 μM for ab1 and 0.8 μM for cdk1. This drug also inhibits the activity of succinate salt hydrate (SSH) with IC50 values of 1 μM for ab1, 2 μM for cdk1, and 4 μM for cdk2/cyclin E. 7H-Pyrrolo[2,3-d]pyrimidine-6-carboxylic acid also inhibits pancreatic cancer cells in culture with an IC50

Please enquire for more information about 5-Chloropyridine-2-boronicacid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-Chloro-3-fluoro-2-pyridinecarboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Indole-4-carboxaldehyde is a natural compound that can be found in the acetate extract of the roots of Scopolia japonica. It has been shown to have an inhibitory effect on locomotor activity and may also have an inhibitory effect on protein synthesis. The mechanism of this inhibition is not yet known, but it may be due to an intramolecular hydrogen bond or other interactions with proteins. Indole-4-carboxaldehyde has also been shown to induce apoptotic cell death in 3T3-L1 preadipocytes by inducing mitochondrial dysfunction and oxidative stress.

Applications 4-(2-Phenoxyethyl)-5-ethyl-1,2,4-triazol-3-one is used as a reagent to synthesize Nefazodone (N389100), a 5HT2-receptor antagonist and a serotonin selective reuptake inhibitor used to treat depression. References Fontaine, R., et al.: J. Clin. Psych., 55, 234 (1994); Rush, A., et al.: Biol. Psych., 44, 3 (1998)

Please enquire for more information about 6-Trifluoromethylpyridine-3,4-diamine HCl including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 5-(4-Methoxyphenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about (S)-1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page

2,3-Dimethylpiperidine hydrobromide is an analgesic drug that has been used in the treatment of pain. It is a phenacyl derivative and has been found to be an effective agonist at opioid receptors. 2,3-Dimethylpiperidine hydrobromide binds to the opioid receptors, activating them and leading to the release of neurotransmitters such as dopamine and serotonin. This compound has been shown to be effective against both acute and chronic pain. The pharmacophore for this drug is based on a pethidine core with two phenacyl groups attached, which are part of a chromatographic resolution. The amide group gives the molecule its solubility in water, while the other groups act as blockers against naphthyridine derivatives and piperidines (e.g., propionate).

7,8-Dimethoxy-9-oxo-9H-indeno[1,2-B]pyrazine-2,3-dicarbonitrile is a fine chemical that is useful for research and as a building block in the synthesis of more complex compounds. It can be used in the synthesis of a range of pharmaceuticals and other chemicals. 7,8-Dimethoxy-9-oxo-9H-indeno[1,2-B]pyrazine is also an excellent reagent for the preparation of other compounds. This compound has been shown to bind to DNA and RNA and its reaction with nucleophiles produces a variety of products.

Please enquire for more information about 4-(2-Hydroxyethyl)piperazine-1-carboximidamide sulfate (salt) including the price, delivery time and more detailed product information at the technical inquiry form on this page

2,6,8-Trichloropurine ammonium salt is a reaction product of 2,6,8-trichloropurine and ammonium hydroxide. It has been shown to inhibit the synthesis of protein in tissue cultures and to be cytotoxic. 2,6,8-Trichloropurine ammonium salt reacts with proteins in the cells. This reaction produces chloropurine dimers that are not soluble in water and can only be solubilized with organic solvents such as acetonitrile or methanol. The formation of these chloropurine dimers is what inhibits protein synthesis in cell cultures. The activation energy for this reaction is approximately 15 kJ/mol. Inactivation of virus by 2,6,8-trichloropurine ammonium salt has been observed at concentrations greater than 1 mM.

Please enquire for more information about 5-Bromopyrazolo[1,5-a]pyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-(Pyridin-3-yl)piperazine hydrochloride including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about N-(4-Fluorophenyl)pyridin-2(1H)-one including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 2-(5-Methoxy)phenol 4-(N-benzyloxycarbonyl)piperidinyl ketone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about tert-Butyl2-formyl-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page

Applications 5-(2-Fluorophenyl)-1H-tetrazole is used in the synthetic preparation of novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors useful in treatment and prevention of CNS diseases and diseases-modulated by mGluR5 receptors. References Gagliardi, S.; et al.: PCT Int. Appl. 45 pp. Patent 2006 CODEN:PIXXD2

Please enquire for more information about (E)-2-(2-(Dimethylamino)ethyl)-1-(1-(pyridin-2-yl)ethylidene)-2,3-dihydro-1H-inden-2-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 6-Chloro-N,N,2-trimethylpyrimidin-4-amine including the price, delivery time and more detailed product information at the technical inquiry form on this page

Tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate is a carbocyclic molecule that is used as an inhibitor of histone deacetylase. It has been shown to have radical, halogen atoms, and unsaturated substituents. Tert-butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate inhibits the activity of phosphodiesterases, which are enzymes that break down cGMP, leading to vasodilation and relaxation of smooth muscle cells. This inhibition may be due to its ability to inhibit histone deacetylase, an enzyme that regulates the transcription of genes involved in inflammatory responses.

Please enquire for more information about (3-Chlorophenyl)(pyridin-4-yl)methanone including the price, delivery time and more detailed product information at the technical inquiry form on this page

Please enquire for more information about 1-Acetylpiperidin-3-ol including the price, delivery time and more detailed product information at the technical inquiry form on this page