Hétérocycles azotés (N)

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6-Chloropyridine-3-carbohydrazide is a benzene molecule that has a conformation of a chair with one hydrogen bond. This molecule has an intramolecular hydrogen bond and an intermolecular hydrogen bond. The molecule contains two pyridine rings and the water molecule is located on the opposite side of the molecule from the two pyridine rings. The molecule also has a crystal structure that is orthorhombic. 6-Chloropyridine-3-carbohydrazide is an experimental compound that was synthesized by heating methanol with hydrazine to form this compound.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

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Cationic surfactant; antiseptic

3-Amino-6-bromo-pyrazine-2-carboxylic acidamide is a chemical compound that belongs to the class of imines. It is an intermediate in the synthesis of other compounds, such as 3,5-dimethylbenzaldehyde and formamidine acetate. 3-Amino-6-bromo-pyrazine-2-carboxylic acidamide can be prepared by reacting ethoxymethylene with chlorinating agents, such as thionyl chloride or phosphorous oxychloride. This reaction produces 3-[(E)-2-(chloromethyl)ethenyl]imine (1), which undergoes a nucleophilic substitution reaction with dimethylamine to produce 3-[(E)-2-(aminomethyl)ethenyl]imine (2). The bromide group is then introduced through the action of trimethylsilyl bromide,

Stability Moisture Sensitive Applications Contains approximately 12% dichloromethane and 8% ethyl acetate

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3-Bromo-2-hydroxypyridine is a low potency competitive inhibitor of the HIV protease that binds to the active site of the enzyme. It has been shown to have anti-cancer activity in prostate cancer cells and also inhibits inflammatory bowel disease by inhibiting serine proteases. 3-Bromo-2-hydroxypyridine is synthesized by reacting 1,2,4-triazole with bromine in the presence of hydrochloric acid. This reaction produces a mixture of substituted pyridines, which are purified using column chromatography. The chemical structure is characterized using NMR spectroscopy and mass spectroscopy.

Applications 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is used as the starting material in the preparation of pyrazine derivatives that are AxI and c-Met receptor enzyme inhibitors. These inhibitors are useful in the treatment of tumors. 2-Amino-5-bromopyrazine-3-carboxylic Acid Methyl Ester is also used in the preparation of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents. References Rushton, L.; et al.: PCT Int. Appl. 119 pp. Patent 2009 CODEN:PIXXD2; Charrier, J-D.; et al.: J. Med. Chem, 54, 2320 (2011)

Applications 2-(Dimethylamino)-4-pyridinyl-boronic Acid can be used to synthesize N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators. References Yang, F., et al.: Bioorg. Med. Chem. Lett., 20, 531 (2010)

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Applications 2,4-Dihydroxypyrrolo[2,3-d]pyrimidine (cas# 39929-79-8) is a compound useful in organic synthesis.

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Applications Labelled N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide (F595365). Rosuvastatin intermediate.

3-[(S)-{1-[2-(4-Fluorophenyl)Ethyl]-4-Piperidinyl}(Hydroxy)Methyl]-2-Methoxyphenol (EFDOH) is a chiral drug that has been shown to be effective in treating toxic epidermal necrolysis. This drug has been shown to inhibit voltage-dependent calcium channels and stimulate mitochondrial functions by increasing ATP production, which may be due to inhibition of hepatic enzymes. EFDOH also inhibits the synthesis of inflammatory mediators such as prostaglandin E2 and leukotriene B4, which can cause damage to skin cells. EFDOH is not metabolized by cytochrome p450 enzymes and does not have any clinically relevant interactions with other drugs. EFDOH is also stable in low doses and does not produce any liver impairment or histological changes in the liver.

2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde is an organic compound that is a glycosidic form of methyl anthranilate. It is an acidophilic amine and has been shown to be active against herpes simplex virus. The asymmetric synthesis of 2,4,6-trichloropyrimidine derivatives can be achieved by reacting the appropriate ketone with 2,4,6-trichloropyrimidine and coupling it with 2 amino groups using trifluoroacetic acid. This reaction produces the desired product in moderate yield with excellent regioselectivity. 2-Amino-4,6-dichloro-pyrimidine-5-carbaldehyde is also a proinflammatory cytokine that induces the release of other cytokines such as IL1β, IL2 and TNFα. The carbonyl group in this molecule reacts with hydroxyl

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4-Amino-2-(dimethylamino)-5-pyrimidinecarbonitrile is an amidine that can be synthesized by the reaction of 4-chloro-2,6-dimethylaniline with ammonium acetate in aqueous solution. This chemical is used as a reagent for the conversion of ketones to amides and for the preparation of guanidines and aldehydes. Due to its nucleophilic properties, 4-amino-2-(dimethylamino)-5-pyrimidinecarbonitrile can be used as an efficient method for cyclizing amidines. This chemical has been shown to undergo an efficient nucleophilic attack on electron rich aromatics, leading to formation of 2-(dimethylamino)pyrimidinones.

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