Mdm2
Os inibidores de Mdm2 têm como alvo a proteína Mdm2, uma ligase de ubiquitina E3 que regula negativamente o supressor tumoral p53. A Mdm2 promove a degradação de p53, impedindo assim a apoptose em células que deveriam passar por morte celular. Inibir a Mdm2 estabiliza p53, aumentando sua atividade supressora de tumores e promovendo a apoptose em células cancerígenas. Os inibidores de Mdm2 são cruciais na pesquisa e terapia do câncer, especialmente para cânceres com vias de p53 intactas. Na CymitQuimica, oferecemos inibidores de Mdm2 de alta qualidade para apoiar sua pesquisa em biologia do câncer, apoptose e desenvolvimento terapêutico.
Produtos da "Mdm2"
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Alrizomadlin
CAS:Alrizomadlin is an orally active MDM2 inhibitor. APG-115 shows significant dose-dependent inhibitory effects on TP53wt AML cell lines.Cost-effective and quality-assured.Fórmula:C34H38Cl2FN3O4Pureza:98.69% - 98.79%Cor e Forma:SolidPeso molecular:642.59Ref: TM-T14303
1mg52,00€5mg111,00€10mg180,00€25mg359,00€50mg588,00€100mg944,00€200mg1.264,00€1mL*10mM (DMSO)159,00€NVP-CGM097
CAS:NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).Fórmula:C38H47ClN4O4Pureza:98.77%Cor e Forma:SolidPeso molecular:659.26Ref: TM-TQ0231
1mg87,00€5mg207,00€10mg341,00€25mg520,00€50mg682,00€100mg944,00€1mL*10mM (DMSO)300,00€RO-5963
CAS:RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).Fórmula:C24H21ClF2N4O5Pureza:98%Cor e Forma:SolidPeso molecular:518.9Ref: TM-T16771
1mg70,00€5mg197,00€10mg284,00€25mg434,00€50mg562,00€100mg780,00€200mg1.035,00€1mL*10mM (DMSO)224,00€Tenovin-6
CAS:Tenovin-6 is a p53 transcriptional activity agonist.Fórmula:C25H34N4O2SPureza:100% - 97.71%Cor e Forma:SolidPeso molecular:454.63Ref: TM-T1818
1mg43,00€2mg56,00€5mg77,00€10mg87,00€25mg157,00€50mg230,00€100mg393,00€500mg930,00€1mL*10mM (DMSO)79,00€MB710
CAS:MB710 is an amino-benzothiazole derivative that tightly binds to the Y220C pocket and stabilizes p53-Y220C in vitro.Fórmula:C16H16IN3O3SPureza:99.02%Cor e Forma:SolidPeso molecular:457.29Nutlin-3b
CAS:Nutlin-3b, a less potent (+)-enantiomer of Nutlin-3, inhibits p53/MDM2 at IC50: 13.6 μM, 150x weaker than Nutlin-3a.Fórmula:C30H30Cl2N4O4Pureza:98.83%Cor e Forma:SolidPeso molecular:581.49Ref: TM-T6614
1mg42,00€2mg55,00€5mg88,00€10mg137,00€25mg255,00€50mg424,00€100mg612,00€1mL*10mM (DMSO)97,00€PhiKan 083
CAS:PhiKan 083 is a carbazole derivativeFórmula:C16H18N2Pureza:98.37%Cor e Forma:SolidPeso molecular:238.33Ref: TM-T16523L
1mg35,00€5mg70,00€10mg111,00€25mg235,00€50mg329,00€100mg464,00€500mg1.008,00€1mL*10mM (DMSO)75,00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Fórmula:C25H35ClN4O2SPureza:99.36%Cor e Forma:SolidPeso molecular:491.09Ref: TM-T8480
1mg39,00€2mg51,00€5mg70,00€10mg88,00€25mg140,00€50mg226,00€100mg376,00€1mL*10mM (DMSO)73,00€NSC 66811
CAS:NSC 66811 inhibits MDM2-p53 interaction with 120 nM affinity, activating p53 in cancer cells.Fórmula:C23H20N2OPureza:96.94%Cor e Forma:SolidPeso molecular:340.42RG7112
CAS:RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.Fórmula:C38H48Cl2N4O4SPureza:99.17% - 99.92%Cor e Forma:SolidPeso molecular:727.78Ref: TM-T6965
1mg48,00€2mg65,00€5mg96,00€10mg169,00€25mg325,00€50mg495,00€100mg718,00€500mg1.501,00€1mL*10mM (DMSO)155,00€Kevetrin hydrochloride
CAS:Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potentialFórmula:C5H10ClN3SPureza:99.32% - 99.93%Cor e Forma:SolidPeso molecular:179.67MA242
CAS:MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).Fórmula:C26H21ClF3N3O5SPureza:98%Cor e Forma:SolidPeso molecular:579.98UC2288
CAS:UC2288, a Sorafenib-based p21 attenuator, reduces p21 levels without affecting its stability.Fórmula:C20H18ClF6N3O2Pureza:99.75%Cor e Forma:SolidPeso molecular:481.82Ref: TM-T9698
1mg48,00€5mg96,00€10mg144,00€25mg263,00€50mg393,00€100mg487,00€200mg607,00€500mg882,00€1mL*10mM (DMSO)96,00€Navtemadlin
CAS:Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM).Cost-effective and quality-assured.Fórmula:C28H35Cl2NO5SPureza:95.55% - 98.86%Cor e Forma:SolidPeso molecular:568.55MI-1061
CAS:MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).Fórmula:C30H26Cl2FN3O4Cor e Forma:SolidPeso molecular:582.45AM-8735
CAS:AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).Fórmula:C27H31Cl2NO6SPureza:98%Cor e Forma:SolidPeso molecular:568.51Amifostine thiol
CAS:Amifostine thiol (WR-1065), an active Amifostine metabolite, is a radioprotective cytoprotectant that activates p53 via JNK pathway.Fórmula:C5H14N2SPureza:≥95.0%Cor e Forma:SolidPeso molecular:134.24Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Fórmula:C20H23N3O2SPureza:99.33%Cor e Forma:SolidPeso molecular:369.48Idasanutlin
CAS:Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).Fórmula:C31H29Cl2F2N3O4Pureza:98.85% - 99.86%Cor e Forma:SolidPeso molecular:616.48Ref: TM-T6254
2mg40,00€5mg60,00€10mg96,00€25mg159,00€50mg226,00€100mg376,00€500mg883,00€1mL*10mM (DMSO)84,00€RITA
CAS:RITA (NSC-652287) forms DNA-DNA/protein cross-links without DNA breaks; disrupts p53/Mdm2 like nutlin-3.Fórmula:C14H12O3S2Pureza:97.76% - 98.85%Cor e Forma:SolidPeso molecular:292.37Ref: TM-T1798
1mg35,00€2mg46,00€5mg66,00€10mg96,00€25mg188,00€50mg344,00€100mg509,00€200mg715,00€500mg1.093,00€1mL*10mM (DMSO)89,00€
