Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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2′-C-Methyl-6-O-methylinosine
CAS:6-MeO-9-(2-C-methyl-β-D-ribofuranosyl)purine is a hypoxanthine analog used in tumor disease research.Fórmula:C12H16N4O5Pureza:99.09%Cor e Forma:SolidPeso molecular:296.28Abrilumab
CAS:Abrilumab (MEDI-7183) is a fully human monoclonal antibody against α4β7 that inhibits the α4β7 integrin.Cor e Forma:LiquidXPW1
CAS:XPW1 is a CDK9 inhibitor with antitumor activity, inhibits DNA repair procedures, and can be used for the research of clear cell renal cell carcinoma.Fórmula:C36H39ClFN7O2Pureza:98.08%Cor e Forma:SoildPeso molecular:656.19Peldesine
CAS:Peldesine (BCX 34), an oral purine nucleoside phosphorylase blocker, halts T-cell growth; used in CTCL, psoriasis, HIV research. IC50: 800 nM.Fórmula:C12H11N5OPureza:99.27% - 99.95%Cor e Forma:SolidPeso molecular:241.25Ref: TM-T12399
1mg114,00€5mg274,00€10mg439,00€25mg727,00€50mg1.017,00€100mg1.378,00€500mg2.737,00€1mL*10mM (DMSO)303,00€Kinesore
CAS:Kinesore is a cell-permeable modulator that binds to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 and SKIP.Fórmula:C20H16Br2N4O4Pureza:97.24%Cor e Forma:SolidPeso molecular:536.17Ref: TM-T15663
2mg43,00€5mg66,00€10mg94,00€25mg159,00€50mg230,00€100mg346,00€200mg520,00€1mL*10mM (DMSO)74,00€c-Myc inhibitor 12
Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].Fórmula:C22H24N6OPureza:98%Cor e Forma:SolidPeso molecular:388.478-Azaguanine
CAS:8-Azaguanine (SK 1150) is a purine analogue with potential antineoplastic activity.Fórmula:C4H4N6OPureza:100% - 99.89%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:152.11Clofarabine-5'-diphosphate
CAS:Clofarabine-5'-diphosphate (Clofarabine-DP) is a metabolite resulting from the phosphorylation of Clofarabine by deoxycytidine kinase (dCK). It can undergo further phosphorylation to become Clofarabine-5'-triphosphate, exhibiting cytotoxicity in cancer cells by inhibiting DNA synthesis and repair.Fórmula:C10H13ClFN5O9P2Cor e Forma:SolidPeso molecular:463.64MC180295
CAS:MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.Fórmula:C17H18N4O3SPureza:99.84%Cor e Forma:SolidPeso molecular:358.41Ref: TM-T5533
1mg56,00€5mg131,00€10mg187,00€25mg319,00€50mg449,00€100mg638,00€200mg842,00€1mL*10mM (DMSO)143,00€2'-Deoxycytidine hydrochloride
CAS:2'-Deoxycytidine hydrochloride is an important deoxyribonucleoside analog and protects mice from the lethal toxicity of cytosine arabinoside(araC).Fórmula:C9H14ClN3O4Pureza:98.96%Cor e Forma:White To Off-White Crystalline PowderPeso molecular:263.68GW406108X
CAS:GW406108X is a Kif15 and ULK1 inhibitor; IC50: 0.82 µM (ATPase), pIC50: 6.37; blocks autophagy.Fórmula:C20H11Cl2NO4Pureza:98%Cor e Forma:SolidPeso molecular:400.21Hycanthone
CAS:Hycanthone (Etrenol(mesylate)) is a potent drug of antischistosomal.Fórmula:C20H24N2O2SPureza:98.78%Cor e Forma:Yellow-Orange Powder (Ntp 1992)Peso molecular:356.48Z62954982
CAS:Z62954982 (ZINC08010136) is a Rac1 inhibitor that inhibits Rac1 activation and reduces proliferation, p38 phosphorylation, and IL-6 levels in pulmonary arteriesFórmula:C20H21N3O5SPureza:98.28%Cor e Forma:SolidPeso molecular:415.46Ref: TM-T37113
1mg38,00€5mg80,00€10mg111,00€25mg183,00€50mg269,00€100mg393,00€200mg560,00€1mL*10mM (DMSO)92,00€10058-F4
CAS:10058-F4 inhibits c-Myc-Max, blocking c-Myc target gene activation, causing cell-cycle arrest & apoptosis.Fórmula:C12H11NOS2Pureza:98% - 99.82%Cor e Forma:SolidPeso molecular:249.35Ezabenlimab
CAS:Ezabenlimab (BI-754091) is an anti-PD-1 mAb, Kd 6 nM, blocks PD-1/PD-Ls, boosts T-cell IFN-γ, inhibits tumors in vivo.Pureza:95% - 95%Cor e Forma:LiquidLY2334737
CAS:LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.Fórmula:C17H25F2N3O5Pureza:98.82%Cor e Forma:SolidPeso molecular:389.39Ref: TM-T4061
1mg62,00€5mg131,00€10mg205,00€25mg378,00€50mg562,00€100mg777,00€200mg1.074,00€1mL*10mM (DMSO)166,00€PF-2771
CAS:PF-2771: potent CENP-E inhibitor, IC50 of 16.1 nM, used in cancer treatment.Fórmula:C29H36ClN5O4Pureza:98%Cor e Forma:SolidPeso molecular:554.08BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Fórmula:C22H32N6·HClPureza:99.21%Cor e Forma:SolidPeso molecular:416.99Ref: TM-T6162
1mg37,00€2mg52,00€5mg79,00€10mg126,00€25mg274,00€50mg454,00€100mg655,00€1mL*10mM (DMSO)87,00€CD532
CAS:CD532: Potent Aurora A inhibitor, IC50=45 nM, blocks kinase activity, degrades MYCN, interacts with AURKA, studies cancer.Fórmula:C26H25F3N8OPureza:99.49%Cor e Forma:SolidPeso molecular:522.52TC-A 2317 hydrochloride
CAS:TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.Fórmula:C19H29ClN6OPureza:98%Cor e Forma:SolidPeso molecular:392.93
