Ciclo celular/Ponto de verificação
Os inibidores do ciclo celular/ponto de verificação são compostos que interrompem a progressão normal do ciclo celular, particularmente em pontos de verificação regulatórios chave. Esses inibidores são cruciais para estudar a divisão celular, entender a proliferação de células cancerígenas e desenvolver terapias anticâncer. Ao direcionar fases específicas do ciclo celular, esses inibidores podem induzir a parada do ciclo celular, levando à apoptose ou senescência em células de divisão rápida. Na CymitQuimica, oferecemos uma ampla gama de inibidores de alta qualidade do ciclo celular/ponto de verificação para apoiar sua pesquisa em biologia do câncer, biologia celular e desenvolvimento de medicamentos.
Subcategorias de "Ciclo celular/Ponto de verificação"
- Aurora Quinase
- CDK
- Ciclo celular/Parada
- Chk
- c-Myc
- Dinamina
- DYRK
- Ferroptose
- HSP
- Integrinas
- Cinesina
- KSP
- LIM Quinase
- Microtúbulo associado
- PKC
- PLK
- Rho
- ROCK
- Wee1
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Produtos da "Ciclo celular/Ponto de verificação"
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Alisertib
CAS:Alisertib (MLN 8237) is a specific Aurora A inhibitor (IC50: 1.2 nM). The selectivity of Alisertib(MLN 8237) is >200-fold higher for Aurora A than Aurora B.Fórmula:C27H20ClFN4O4Pureza:100% - 99.82%Cor e Forma:SolidPeso molecular:518.92Ref: TM-T2241
5mg55,00€10mg96,00€25mg155,00€50mg226,00€100mg354,00€200mg454,00€500mg743,00€1mL*10mM (DMSO)63,00€4μ8C
CAS:4μ8C (IRE1 Inhibitor III)(IC50=76 nM) is an effective and specific IRE1 Rnase inhibitor.Fórmula:C11H8O4Pureza:97.48% - 98.45%Cor e Forma:SolidPeso molecular:204.18CDK-IN-15
CAS:CDK-IN-15 (Compound 456) is an effective inhibitor of Cyclin A, exhibiting an IC50 value of 0.14 μM.Fórmula:C45H63Cl2F4N7O8Cor e Forma:SolidPeso molecular:976.92GDC0575 monohydrochloride
CAS:GDC0575 (ARRY575), a potent Chk1 inhibitor, IC50 1.2nM, disrupts cell cycle arrest, allowing DNA repair before mitosis.Fórmula:C16H21BrClN5OPureza:97.85%Cor e Forma:SolidPeso molecular:414.73Ref: TM-T27407
1mg46,00€2mg58,00€5mg85,00€10mg108,00€25mg187,00€50mg269,00€100mg376,00€200mg548,00€1mL*10mM (DMSO)87,00€CDK9-IN-2
CAS:CDK9-IN-2, a CDK9 inhibitor from patent WO/2012131594A1, IC50: 5 nM in A2058, 7 nM in H929 at 72hr.Fórmula:C23H25ClFN5Pureza:99%Cor e Forma:SolidPeso molecular:425.93Ref: TM-T14918
1mg88,00€5mg187,00€10mg281,00€25mg487,00€50mg705,00€100mg998,00€1mL*10mM (DMSO)207,00€Emzadirib
CAS:Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.Fórmula:C27H40N4O6S2Pureza:99.79%Cor e Forma:SolidPeso molecular:580.7610074-A4
CAS:10074-A4 is a c-Myc binding compound that associates with c-Myc370-409 and behaves like a “ligand cloud” around a “protein cloud”, with distinct features fromFórmula:C18H14Cl2N2O3SPureza:98.01%Cor e Forma:SolidPeso molecular:409.29Ref: TM-T9628
1mg71,00€5mg135,00€10mg197,00€25mg335,00€50mg480,00€100mg662,00€200mg892,00€1mL*10mM (DMSO)156,00€BI-1950
CAS:BI-1950: potent inhibitor of LFA-1, key in immune function and drug target.Fórmula:C32H26Cl2FN7O3Pureza:98%Cor e Forma:SolidPeso molecular:646.5MYCi975
CAS:MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.Fórmula:C25H16Cl2F6N2O2Pureza:99.3% - 99.58%Cor e Forma:SolidPeso molecular:561.3AG-024322
CAS:AG-024322 is a pan-CDK inhibitor with antitumor activity, induces apoptosis, and can be used in the study of metabolic diseases.Fórmula:C23H20F2N6Pureza:98.53%Cor e Forma:SolidPeso molecular:418.44TG003
CAS:TG003 is a Clk1/Sty inhibitor that inhibits Clk1 and Clk4, suppresses cancer cell growth, and induces apoptosis.Fórmula:C13H15NO2SPureza:99.46%Cor e Forma:SolidPeso molecular:249.33Ref: TM-T60367
1mg50,00€5mg97,00€10mg159,00€25mg281,00€50mg465,00€100mg558,00€200mg810,00€1mL*10mM (DMSO)170,00€PHA-680632
CAS:PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.Fórmula:C28H35N7O2Pureza:98.20%Cor e Forma:SolidPeso molecular:501.62T4 UvsX Recombinase
T4 UvsX Recombinase initiates DNA replication on double-stranded templates by catalyzing synapsis with a homologous primer single strand.Pureza:98%Cor e Forma:Odour SoliddGTP
CAS:dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the guanosine nucleotides which is highly susceptible to oxidative damage to 8-O-GDP, 8-O-dGTP, 8-O-GTP, andFórmula:C10H16N5O13P3Pureza:99.9%Cor e Forma:SolidPeso molecular:507.18Avotaciclib hydrochloride
Avotaciclib hydrochloride, a CDK1 inhibitor, is the hydrochloride salt of Avotaciclib and exhibits potential therapeutic use in specific malignancies, includingFórmula:C13H12ClN7OPureza:98%Cor e Forma:SolidPeso molecular:317.73RI-2
CAS:RI-2, a potent RAD51 inhibitor, has a 44.17 μM IC50 and selectively blocks human HR repair.Fórmula:C21H18Cl2N2O4Pureza:98.85% - 99.86%Cor e Forma:SolidPeso molecular:433.28Ref: TM-T2628
1mg73,00€2mg97,00€5mg160,00€10mg281,00€25mg435,00€50mg640,00€100mg910,00€1mL*10mM (DMSO)170,00€CDK9-IN-29
CAS:CDK9-IN-29 (compound Z11) is a potent inhibitor of CDK9, exhibiting high kinase selectivity and an IC50 value of 3.20 nM.Fórmula:C29H33F2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:553.6PD-1/PD-L1-IN-50
Compound LG-12, known chemically as PD-1/PD-L1-IN-50, is an inhibitor of PD-1/PD-L1. It enhances the secretion of IFN-γ, promotes the activation of CD8+ T cells, and activates T cell-mediated anti-tumor immunity.Cor e Forma:Odour SolidBMS-8
CAS:BMS-8 is a novel inhibitor of the PD-1/PD-L1 interaction (IC50: 7.2 μM) by binding directly to PD-L1 and inducing the formation of PD-L1 homodimers.Fórmula:C27H28BrNO3Pureza:99.06%Cor e Forma:SolidPeso molecular:494.42Ref: TM-T26859
1mg39,00€5mg84,00€10mg131,00€25mg269,00€50mg432,00€100mg638,00€200mg909,00€1mL*10mM (DMSO)96,00€Reversine
CAS:Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).Fórmula:C21H27N7OPureza:98% - 99.75%Cor e Forma:SolidPeso molecular:393.49Ref: TM-T1825
1mg38,00€2mg49,00€5mg70,00€10mg88,00€25mg164,00€50mg224,00€100mg393,00€1mL*10mM (DMSO)70,00€
