NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Produtos da "NF-κB"
Ordenar por
NLRP3 agonist 1
CAS:Vatalanib hydrochloride (PTK787 hydrochloride) is a VEGF inhibitor that reduces the number and area of Aβ plaques in the cortex of 5xFAD mice.Fórmula:C15H16N6Pureza:99.01%Cor e Forma:SolidPeso molecular:280.33Salicortin
CAS:Salicortin, a phenolic glycoside from Populus and Salix, has anti-adipogenic, anti-amnesic, and immune effects.Fórmula:C20H24O10Pureza:98%Cor e Forma:SolidPeso molecular:424.40GGTI 2147
CAS:GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.Fórmula:C28H30N4O3Pureza:99.32%Cor e Forma:SolidPeso molecular:470.56BEC hydrochloride
CAS:BEC hydrochloride (BEC HCl) is a competitive arginase inhibitor, which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II.Fórmula:C5H12BNO4S·ClHPureza:98.65% - 99.28%Cor e Forma:SolidPeso molecular:229.49Ref: TM-T6779
1mg39,00€2mg49,00€5mg88,00€10mg153,00€25mg283,00€50mg535,00€100mg747,00€1mL*10mM (DMSO)88,00€Sanggenon A
CAS:Sanggenon A (Sanggenone A) exhibits anti-inflammatory properties by modulating the NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells, and itFórmula:C25H24O7Pureza:98%Cor e Forma:SolidPeso molecular:436.45Narlumosbart
CAS:Narlumosbart (JMT103) is an IgG4κ monoclonal antibody that selectively binds to the receptor activator of nuclear factor-κB ligand (RANKL)[1].Pureza:98%Cor e Forma:LiquidRIPK1-IN-19
CAS:RIPK1-IN-19 is a selective and potent RIPK1 inhibitor that protects against cell necrosis in the tnf α-induced SIRS model and IMQ-induced psoriasis model.Fórmula:C28H25FN6O2Pureza:98.81%Cor e Forma:SolidPeso molecular:496.54PK68
CAS:PK68 selectively inhibits RIPK1 (IC50=90nM), potentially useful in inflammation and cancer metastasis studies.Fórmula:C22H24N4O3SPureza:98.09% - 98.13%Cor e Forma:SolidPeso molecular:424.52Ref: TM-T12493
1mg86,00€5mg170,00€10mg274,00€25mg520,00€50mg750,00€100mg1.026,00€200mg1.388,00€1mL*10mM (DMSO)188,00€IMD-biphenylA
CAS:IMD-biphenylA, a novel imidazoquinolinone-based dimer, functions as an NF-κB immunomodulator and enhances the adjuvant properties of small molecule immuneFórmula:C35H33N5O2Pureza:98%Cor e Forma:SolidPeso molecular:555.67(Rac)-BAY-985
CAS:(Rac)-BAY-985 is a potent, ATP-competitive and selective inhibitor of TBK1(IC50 of 1.5 nM),with antitumor efficacy.Fórmula:C27H30F3N9OPureza:98%Cor e Forma:SolidPeso molecular:553.58DCZ0415
CAS:DCZ0415: Potent TRIP13 inhibitor; combats myeloma in vitro, in vivo, and in drug-resistant patients; hinders DNA repair and NF-κB activity.Fórmula:C23H20N2O2Pureza:99.34%Cor e Forma:SolidPeso molecular:356.42Ref: TM-T10981
1mg52,00€5mg116,00€10mg188,00€25mg354,00€50mg588,00€100mg873,00€1mL*10mM (DMSO)126,00€Kukoamine A
CAS:Kukoamine A: anticancer, cytoprotective, antioxidant, anti-inflammatory, inhibits trypanothione reductase (mixed inhibitor, Ki=1.8µM).Fórmula:C28H42N4O6Pureza:97.45% - 99.28%Cor e Forma:SolidPeso molecular:530.66Ginsenoside Rk1
CAS:Ginsenoside Rk1 is a component created by processing the ginseng plant at high temperatures.Fórmula:C42H70O12Pureza:99.13%Cor e Forma:SolidPeso molecular:767IRAK4-IN-1
CAS:IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM.Fórmula:C19H23N5OPureza:98.18% - 99.74%Cor e Forma:SolidPeso molecular:337.42Dihydroartemisinin
CAS:Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.Fórmula:C15H24O5Pureza:99.41% - 99.72%Cor e Forma:White SolidPeso molecular:284.35Aspirin
CAS:Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.Fórmula:C9H8O4Pureza:99.78% - 99.91%Cor e Forma:White Solid CrystallinePeso molecular:180.16IRAK4-IN-7
CAS:IRAK4-IN-7 (CA-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.Fórmula:C21H19N7O3Pureza:99.50%Cor e Forma:SolidPeso molecular:417.42Ref: TM-T5354
1mg37,00€2mg52,00€5mg79,00€10mg119,00€25mg210,00€50mg354,00€100mg528,00€1mL*10mM (DMSO)87,00€Ginsenoside Rg1
CAS:Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng).Fórmula:C42H72O14Pureza:99% - 99.74%Cor e Forma:White Crystalline PowderPeso molecular:801.01Vamorolone
CAS:Vamorolone (VBP15) is a steroid-like drug that treats muscular dystrophy with fewer side effects and inhibits NF-κB.Fórmula:C22H28O4Pureza:99.54%Cor e Forma:SolidPeso molecular:356.46Ref: TM-T17217
1mg37,00€2mg52,00€5mg79,00€10mg111,00€25mg188,00€50mg298,00€100mg444,00€200mg640,00€1mL*10mM (DMSO)87,00€Mollugin
CAS:Mollugin could be a JAK2 inhibitor, anti-inflammatory, chemotherapeutic agent in OSCCs, bone disorder therapy, and modulates HER2 in cancer.Fórmula:C17H16O4Pureza:98.31% - ≥95%Cor e Forma:SolidPeso molecular:284.31
