NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Produtos da "NF-κB"
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Supercinnamaldehyde
CAS:Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1), exhibiting an EC50 of 0.8 μM, and induces activation of TRPA1 ionFórmula:C12H11NO2Pureza:98.89%Cor e Forma:SolidPeso molecular:201.22Stachydrine
CAS:Stachydrine, found in leonurus herb, aids blood flow, blocks NF-κB pathway, and indicates citrus intake.Fórmula:C7H13NO2Pureza:≥95%Cor e Forma:SolidPeso molecular:143.18OPHIOPOGONIN D
CAS:Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.Fórmula:C44H70O16Pureza:99.46% - ≥95%Cor e Forma:SolidPeso molecular:855.02Ergolide
CAS:Ergolide, from Inula Britannica, inhibits iNOS and COX-2 by deactivating NF-κB in macrophages.Fórmula:C17H22O5Pureza:99.64%Cor e Forma:SolidPeso molecular:306.35Ref: TM-T13686
1mg74,00€5mg146,00€10mg243,00€25mg394,00€50mg548,00€100mg735,00€1mL*10mM (DMSO)170,00€Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 98.91%Cor e Forma:SolidPeso molecular:383.82IRAK inhibitor 1
CAS:IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).Fórmula:C17H19N5Pureza:100% - 97.78%Cor e Forma:SolidPeso molecular:293.37Ref: TM-T5094
1mg95,00€2mg125,00€5mg202,00€10mg283,00€25mg472,00€50mg687,00€100mg938,00€1mL*10mM (DMSO)135,00€Erdosteine
CAS:Erdosteine (RV 144), a mucolytic thiol, modulates mucus and aids expectoration, reduces cough, and protects lungs from smoke damage.Fórmula:C8H11NO4S2Pureza:99.43% - 99.94%Cor e Forma:White Or Almost White Crystalline PowderPeso molecular:249.31CTP-NBD
CAS:CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].Fórmula:C121H194N46O32Pureza:98%Cor e Forma:SolidPeso molecular:2805.12Phorbol 12-myristate 13-acetate
CAS:Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB.Fórmula:C36H56O8Pureza:100% - 99.5%Cor e Forma:White To Off-White SolidPeso molecular:616.83Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Fórmula:C23H34O5Pureza:99.12%Cor e Forma:White-Yellowish To Yellow Powder Solid PowderPeso molecular:390.51Muramyl dipeptide
CAS:MDP is a synthetic peptide promoting bone formation by modulating osteoclasts, osteoblasts, and Runx2 expression via MAPK pathways.Fórmula:C19H32N4O11Pureza:100%Cor e Forma:SolidPeso molecular:492.48Ref: TM-T16159
1mg88,00€5mg178,00€10mg279,00€25mg545,00€50mg777,00€100mg1.064,00€200mg1.415,00€1mL*10mM (DMSO)188,00€Bay 11-7085
CAS:Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).Fórmula:C13H15NO2SPureza:99.76% - 99.83%Cor e Forma:White SolidPeso molecular:249.33Ref: TM-T1934
2mg35,00€5mg50,00€10mg66,00€25mg85,00€50mg124,00€100mg197,00€200mg255,00€1mL*10mM (DMSO)62,00€Andrographolide
CAS:Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potentialFórmula:C20H30O5Pureza:100% - 99.97%Cor e Forma:PowderPeso molecular:350.45Delanzomib
CAS:Delanzomib (CEP-18770) is an oral proteasome inhibitor with an IC50 of 3.8 nM, targeting chymotrypsin-like activity with minimal effect on other activities.Fórmula:C21H28BN3O5Pureza:95.52% - 99.46%Cor e Forma:SolidPeso molecular:413.28Ref: TM-T6027
1mg46,00€5mg96,00€10mg140,00€25mg274,00€50mg439,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)95,00€IRAK4-IN-4
CAS:IRAK4-IN-4 (compound 15) inhibits cyclic GMP-AMP synthase (cGAS) with an IC50 of 2.1 nM.IRAK4-IN-4 is an interleukin-1 receptor-associated kinase 4 (IRAK4)Fórmula:C22H16N2O2Pureza:99.52%Cor e Forma:SolidPeso molecular:340.37Ref: TM-T11673
1mg64,00€5mg145,00€10mg212,00€25mg378,00€50mg567,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)160,00€Demethyleneberberine chloride
CAS:Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-Fórmula:C19H18ClNO4Pureza:98%Cor e Forma:SolidPeso molecular:359.8RIPK1-IN-4
CAS:RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50sFórmula:C23H23N5O2Pureza:99.66%Cor e Forma:SolidPeso molecular:401.46DMAPT
CAS:DMAPT is a water-soluble PTL analogue, orally active NF-κB inhibitor with 1.7 μM LD50 in acute myeloid leukemia cells.Fórmula:C17H27NO3Pureza:100.00%Cor e Forma:SolidPeso molecular:293.4Triptolide
CAS:Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation.Fórmula:C20H24O6Pureza:97.19% - 99.97%Cor e Forma:White To Off-White SolidPeso molecular:360.4Ref: TM-T2179
1mg44,00€2mg58,00€5mg96,00€10mg137,00€25mg310,00€50mg462,00€100mg553,00€1mL*10mM (DMSO)85,00€Tomatidine
CAS:Tomatidine serves as an anti-inflammatory agent by inhibiting NF-κB and JNK signaling pathways.Fórmula:C27H45NO2Pureza:98.38% - 99.98%Cor e Forma:SolidPeso molecular:415.65
