NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Produtos da "NF-κB"
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EN450
CAS:EN450 is a targeted cysteine degrader of NF-κB with antiproliferative activity and potential anticancer activity for the study of leukemia.Fórmula:C11H13ClN2O3SPureza:99.72%Cor e Forma:SoildPeso molecular:288.75Ref: TM-T77525
1mg47,00€5mg87,00€10mg144,00€25mg283,00€50mg432,00€100mg628,00€500mg1.301,00€1mL*10mM (DMSO)97,00€Lidocaine Hydrochloride hydrate
CAS:Lidocaine Hydrochloride hydrate is an amide local anesthetic, has anti-inflammatory property.Fórmula:C14H22N2O·HCl·H2OPureza:99.95%Cor e Forma:SolidPeso molecular:288.82Anti-inflammatory agent 60
Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-cateninPureza:98%Cor e Forma:Odour SolidGSK872 HCl(1346546-69-7 free base)
CAS:GSK872 HCl(1346546-69-7 free base) (GSK2399872A) is an effective and specific RIP3 kinase inhibitor.Fórmula:C19H18ClN3O2S2Pureza:99%Cor e Forma:SolidPeso molecular:419.94Pristimerin
CAS:Pristimerin has anticancer properties, counters hypoxia-induced cancer spread, and reduces inflammation by inhibiting ROS/IKK/NF-κB pathways.Fórmula:C30H40O4Pureza:99.43% - 99.59%Cor e Forma:SolidPeso molecular:464.64(E/Z)-BCI
CAS:(E/Z)-BCI (NSC-150117), a dual-specificity phosphatase 6 (DUSP6) inhibitor with anti-inflammatory properties, reduces LPS-induced inflammatory mediators and ROSFórmula:C22H23NOPureza:98.55%Cor e Forma:SolidPeso molecular:317.42Ref: TM-T11139
1mg80,00€5mg155,00€10mg283,00€25mg452,00€50mg638,00€100mg848,00€200mg1.121,00€1mL*10mM (DMSO)170,00€RIP1 kinase inhibitor 6
CAS:RIP1 Kinase Inhibitor 6 is a potent and selective inhibitor of RIP1 kinase, demonstrating inhibitory activity with an IC50 of less than 100 nM in a human R1P1Fórmula:C19H18F2N2O3Pureza:98%Cor e Forma:SolidPeso molecular:360.35TBK1/IKKε-IN-2
CAS:TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.Fórmula:C26H27N5O3Pureza:98.89%Cor e Forma:SolidPeso molecular:457.52Ref: TM-T15559
1mg92,00€5mg188,00€10mg305,00€25mg487,00€50mg660,00€100mg847,00€1mL*10mM (DMSO)188,00€TAK-243
CAS:TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM).Fórmula:C19H20F3N5O5S2Pureza:98.09% - 98.93%Cor e Forma:SolidPeso molecular:519.52Ref: TM-T16974
1mg48,00€2mg64,00€5mg96,00€10mg150,00€25mg268,00€50mg459,00€100mg658,00€1mL*10mM (DMSO)107,00€SBI-0640726
CAS:SBI-0640726, an eIF4G1 inhibitor, exhibits antiproliferative activity against melanoma. It disrupts the eIF4F translation initiation complex by inhibiting the AKT and NF-kB signaling pathways. Additionally, SBI-0640726 inhibits the growth of melanoma with NRAS and BRAF mutations in vitro.Fórmula:C23H15ClN2O2Cor e Forma:SolidPeso molecular:386.83HPN-01
CAS:HPN-01 (IKK inhibitor XII) is an IKK inhibitor that inhibits IKK-α and IKK-ε, prolongs the lifespan of mice, and can be used to study immune disorders.Fórmula:C19H16ClN3O3SPureza:98.07%Cor e Forma:SolidPeso molecular:401.87OT-551 HCl
CAS:OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macularFórmula:C13H24ClNO3Pureza:99.71%Cor e Forma:SolidPeso molecular:277.79Ref: TM-T28273L
1mg115,00€5mg245,00€10mg363,00€25mg562,00€50mg802,00€100mg1.111,00€200mg1.491,00€1mL*10mM (DMSO)295,00€Theophylline
CAS:Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and centralFórmula:C7H8N4O2Pureza:99.47% - 99.97%Cor e Forma:White Solid PowderPeso molecular:180.16HOIPIN-8 sodium
CAS:HOIPIN-8 sodium is a LUBAC inhibitor for the study of inflammatory and immune diseases.Fórmula:C23H15F2N4NaO3Pureza:97.34%Cor e Forma:SolidPeso molecular:456.38BAY32-5915
CAS:BAY32-5915 is a selective inhibitor of IKKalpha.Fórmula:C10H7NO3Pureza:96.48% - 97.00%Cor e Forma:Yellow Crystalline PowderPeso molecular:189.17Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Fórmula:C30H48O3Pureza:99.12% - 99.7%Cor e Forma:White Crystalline PowderPeso molecular:456.7Anti-inflammatory agent 50
Anti-inflammatory agent 50 (compound a1), a derivative of Fusidic acid, exerts its effects through inhibition of inflammatory mediators including NO, IL-6, andFórmula:C40H55N3O6Pureza:98%Cor e Forma:SolidPeso molecular:673.88Caffeic Acid Phenethyl Ester
CAS:CAPE, in propolis, blocks NF-kappa B, suppresses p70S6K/Akt pathways, and inhibits PDGF, aiding in cancer protection and immune modulation.Fórmula:C17H16O4Pureza:99.18% - 99.35%Cor e Forma:Less Transparent Liquid Colorless Transparent LiquidPeso molecular:284.31Specnuezhenide
CAS:Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling.Cost-effective and quality-assured.Fórmula:C31H42O17Pureza:98% - 99.12%Cor e Forma:SolidPeso molecular:686.66Ref: TM-T3803
2mg38,00€5mg52,00€10mg88,00€25mg164,00€50mg233,00€100mg344,00€500mg830,00€1mL*10mM (DMSO)82,00€Damascenone
CAS:Damascenone (trans-damascenone) is a norisoprenoid ketone mainly found in red wines. It occurs naturally in tomato and grapes.Fórmula:C13H18OPureza:98.03%Cor e Forma:Colorless LiquidPeso molecular:190.28
