NF-κB
O fator nuclear kappa-light-chain-enhancer de células B ativadas (NF-κB) é um fator de transcrição que regula a expressão de genes envolvidos em respostas imunes, inflamação, sobrevivência celular e proliferação. O NF-κB é ativado em resposta a vários estímulos, incluindo citocinas, patógenos e sinais de estresse. A desregulação da sinalização do NF-κB está associada a doenças inflamatórias crônicas, câncer e distúrbios autoimunes. Na CymitQuimica, oferecemos uma seleção abrangente de moduladores da via NF-κB para apoiar sua pesquisa em inflamação, oncologia e regulação imunológica.
Produtos da "NF-κB"
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NP3-146
CAS:NP3-146 (NLRP3-IN-5) is an inflammasome NLRP3 inhibitor with potential anti-inflammatory activity for the study of autoimmune diseases.Fórmula:C20H27ClN2O5SPureza:99.21%Cor e Forma:SolidPeso molecular:442.96RIPK2-IN-5
CAS:RIPK2-IN-5 is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with potential anti-inflammatory activity for the study of diseases caused by immune dysfunctions.Fórmula:C21H14N4SPureza:98.85%Cor e Forma:SoildPeso molecular:354.43Sappanone A
CAS:Sappanone A is a high isoflavanone with anti-inflammatory properties.Sappanone A reduces allergic airway inflammation in ovalbumin-induced asthma.Fórmula:C16H12O5Pureza:97.48% - 99.18%Cor e Forma:SolidPeso molecular:284.26Pinocembrin
CAS:Pinocembrin (5,7-Dihydroxyflavanone) is a flavanone, a type of flavonoid. It is an antioxidant found in damiana, honey, fingerroot, and propolis.Fórmula:C15H12O4Pureza:100% - 99.61%Cor e Forma:SolidPeso molecular:256.25NF-κB/MAPK-IN-1
CAS:NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).Fórmula:C27H27NO7Pureza:97.03%Cor e Forma:SolidPeso molecular:477.51Ref: TM-T63119
1mg47,00€2mg60,00€5mg87,00€10mg154,00€25mg329,00€50mg492,00€100mg710,00€1mL*10mM (DMSO)93,00€CBL0137 hydrochloride
CAS:CBL0137 hydrochloride (Curaxin-137 hydrochloride) is an inhibitor of the histone chaperone FACT, which also activates p53 and inhibits NF-κB.Cost-effective and quality-assured.Fórmula:C21H25ClN2O2Pureza:98.59% - 99.35%Cor e Forma:SolidPeso molecular:372.88Nimbolide
CAS:Nimbolide, from neem, inhibits CDK4/6, NF-κB, Wnt, PI3K-Akt, MAPK, JAK-STAT pathways and induces apoptosis.Fórmula:C27H30O7Pureza:95.84% - 99.4%Cor e Forma:SolidPeso molecular:466.52Ref: TM-T16324
1mg88,00€5mg216,00€10mg376,00€25mg810,00€50mg1.074,00€100mg1.454,00€200mg1.882,00€1mL*10mM (DMSO)235,00€IRAK-1-4 Inhibitor I
CAS:IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.Fórmula:C20H21N5O4Pureza:100% - 99.89%Cor e Forma:SolidPeso molecular:395.41Ref: TM-T2457
1mg44,00€5mg79,00€10mg110,00€25mg224,00€50mg376,00€100mg540,00€500mg1.130,00€1mL*10mM (DMSO)79,00€Stipuleanoside R2
CAS:Stipuleanoside R2 is a triterpenoid saponin that inhibits NF-κB activation and has potential applications in inflammation, immunology, and cancer research.Fórmula:C53H84O23Pureza:98%Cor e Forma:SolidPeso molecular:1089.22Esculentoside H
CAS:Phytolaccaceae has anti-tumor activity, the mechanism may be related to the capacity of Esculentoside H for TNF release.Fórmula:C48H76O21Pureza:98.04% - 99.3%Cor e Forma:SolidPeso molecular:989.1Sootepin D
CAS:Sootepin D is a triterpene from the apical bud of Gardenia sootepensis, and is TNF-α-induced NF-κB inhibitor(IC50 of 8.3μM),with anti-inflammatory activity.Fórmula:C31H48O4Pureza:98%Cor e Forma:SolidPeso molecular:484.71IMD-0560
CAS:IMD-0560 is a novel inhibitor of IκB kinase β.Fórmula:C15H8BrF6NO2Pureza:99.51%Cor e Forma:SolidPeso molecular:428.12Sulindac
CAS:Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity.Fórmula:C20H17FO3SPureza:99.09% - 99.15%Cor e Forma:Yellow SolidPeso molecular:356.41Goshonoside F5
CAS:Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.Fórmula:C32H54O13Pureza:98%Cor e Forma:SolidPeso molecular:646.771CID-2858522
CAS:CID-2858522 is an effective and specific antigen receptor-mediated NF-κB activation inhibitor (IC50: 70 nM).Fórmula:C28H39N3O3Pureza:96.11%Cor e Forma:SolidPeso molecular:465.63Kuromanin chloride
CAS:Kuromanin chloride (Chrysontemin chloride) is potent antioxidants and free radical scavengers, may act as modulators of gene regulation and signal transductionFórmula:C21H21ClO11Pureza:97.27% - 98.69%Cor e Forma:SolidPeso molecular:484.84Ref: TM-T3406
1mg35,00€2mg50,00€5mg82,00€10mg110,00€25mg207,00€50mg306,00€100mg459,00€1mL*10mM (DMSO)88,00€IRAK4-IN-27
IRAK4-IN-27 (Compound 22) is a potent and selective IRAK4 inhibitor, demonstrating an IC50 of 8.7 nM.Fórmula:C23H22N6O3Pureza:98%Cor e Forma:SolidPeso molecular:430.46Cantleyoside
CAS:Cantleyoside, a natural cyclic enol ether terpene glycoside from Pterocephalus hookeri, can activate of the AMPK/Sirt1/NF-κB signaling pathway.Fórmula:C33H46O19Pureza:99.85%Cor e Forma:SolidPeso molecular:746.71TNFα activity modulator 3
CAS:TNFα Activity Modulator 3 (example 6) is a molecule that regulates TNF activity by inhibiting TNFα-induced NF-κB activation, making it applicable for related research.Fórmula:C27H24F2N6O2Cor e Forma:SolidPeso molecular:502.52BAL-0028
CAS:BAL-0028 is a potent inhibitor of NLRP3 activation (IC50: 25 nM) with anti-inflammatory activity for cancer research.Fórmula:C24H22FN3O2Pureza:99.16%Cor e Forma:SoildPeso molecular:403.45
