CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Produtos da "CCR"
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Lanerkitug
Lanerkitug is a humanized IgG1λ2 antibody that targets CCR8, with HumanIgG1lambda2, Isotype Control serving as its corresponding isotype control.Cor e Forma:Odour LiquidINCB3344
CAS:INCB3344 is an effective, specific and orally bioavailable CCR2 antagonist with IC50 values of 9.5 nM (mCCR2) and 5.1 nM (hCCR2) in binding antagonism and 7.8Fórmula:C29H34F3N3O6Pureza:98.00% - 98.2%Cor e Forma:SolidPeso molecular:577.59Ref: TM-TQ0103
1mg70,00€5mg153,00€10mg243,00€25mg411,00€50mg610,00€100mg868,00€1mL*10mM (DMSO)188,00€PF-4136309
CAS:PF-4136309 (INCB8761) is a specific, effective, and orally bioavailable CCR2 antagonist.Fórmula:C29H31F3N6O3Pureza:98.85% - 99.47%Cor e Forma:SolidPeso molecular:568.59BI-6901
CAS:BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.Fórmula:C23H27N5O3SPureza:99.83%Cor e Forma:SolidPeso molecular:453.56CCX140
CAS:CCX140 (CCX140-B) (CCX140-B) is an antagonist of CCR2.Fórmula:C20H13ClF3N5O3SPureza:97.58% - 99.95%Cor e Forma:SolidPeso molecular:495.86Vercirnon
CAS:Vercirnon (Traficet-EN) is a selective and potent antagonist of CCR9 (IC50: 10 nM). It is also used in the research of inflammatory bowel diseases.Fórmula:C22H21ClN2O4SPureza:99.23%Cor e Forma:SolidPeso molecular:444.93Ref: TM-T17225
1mg105,00€5mg259,00€10mg406,00€25mg680,00€50mg938,00€100mg1.301,00€500mg2.593,00€1mL*10mM (DMSO)363,00€CCR8 antagonist 1
CAS:CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.Fórmula:C26H29N3O5SPureza:97.33%Cor e Forma:SolidPeso molecular:495.59Vicriviroc maleate
CAS:Vicriviroc maleate (SCH-417690 (maleate))(Sch-417690) is a piperazine-based CCR5 receptor antagonist with activity against human immunodeficiency virus.Fórmula:C32H42F3N5O6Pureza:97.51% - 98.16%Cor e Forma:SolidPeso molecular:649.7RE-640
CAS:NSC-5844 (RE-640) (RE640) is a bisquinoline compound with C-C chemokine receptor type 1 (CCR1)-agonistic activities.Fórmula:C20H16Cl2N4Pureza:99.60% - 99.87%Cor e Forma:SolidPeso molecular:383.27MLN-3897 TFA
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes.Fórmula:C32H32ClF3N2O6Pureza:98.62%Cor e Forma:SolidPeso molecular:633.05SB-649701
CAS:SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].Fórmula:C27H28N4O3Pureza:98%Cor e Forma:SolidPeso molecular:456.54SB297006
CAS:SB297006 is an antagonist of C-C chemokine receptor 3, which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ.Fórmula:C18H18N2O5Pureza:99.59%Cor e Forma:SolidPeso molecular:342.35AZD2098
CAS:AZD2098 is a potent CC-chemokine receptor 4 (CCR4) inhibitor used for asthma research.Fórmula:C11H9Cl2N3O3SPureza:99.80% - 99.92%Cor e Forma:SolidPeso molecular:334.18Ref: TM-T4300
1mg35,00€5mg70,00€10mg111,00€25mg230,00€50mg354,00€100mg530,00€500mg1.121,00€1mL*10mM (DMSO)78,00€CCR6 inhibitor 1
CAS:CCR6 inhibitor 1 selectively blocks CCR6 (0.45 nM in monkeys, 6 nM in humans), aiding in vitro/vivo disease studies.Fórmula:C24H23F3N4O3SPureza:98.91%Cor e Forma:SolidPeso molecular:504.52Ref: TM-T10715
1mg116,00€5mg283,00€10mg424,00€25mg682,00€50mg934,00€100mg1.301,00€500mg2.612,00€1mL*10mM (DMSO)311,00€TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Fórmula:C33H39ClN2O2Pureza:99.21%Cor e Forma:SolidPeso molecular:531.13CCR2 antagonist 1
CAS:CCR2 antagonist 1 is a high-affinity and long-residence-time antagonist of CCR2 (Ki: 2.4 nM).Fórmula:C28H32BrF3N2OCor e Forma:SolidPeso molecular:549.47BX471
CAS:BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist.Fórmula:C21H24ClFN4O3Pureza:98% - 99.94%Cor e Forma:SolidPeso molecular:434.89Ref: TM-T2375
1mg38,00€5mg90,00€10mg124,00€25mg212,00€50mg329,00€100mg515,00€200mg782,00€1mL*10mM (DMSO)90,00€DAPTA
CAS:DAPTA (Adaptavir) is an inhibitor of CCR5, shows potent anti-HIV activities.Fórmula:C35H56N10O15Pureza:100%Cor e Forma:SolidPeso molecular:856.88Bindarit
CAS:Bindarit is a selective inhibitor of monocyte chemoattractant proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.Cost-effective and quality-assured.Fórmula:C19H20N2O3Pureza:98.35% - 98.71%Cor e Forma:SolidPeso molecular:324.37Ref: TM-T6413
1mg57,00€5mg123,00€10mg187,00€25mg315,00€50mg472,00€100mg677,00€500mg1.388,00€1mL*10mM (DMSO)137,00€CCR3 antagonist 1
CAS:CCR3 antagonist 1 is a potent CCR3 antagonist, used for the research of inflammatory and immunologic diseases.Fórmula:C19H21Cl2N3O4S2Pureza:99.85%Cor e Forma:SolidPeso molecular:490.42Ref: TM-T10156
1mg92,00€5mg188,00€10mg305,00€25mg489,00€50mg655,00€100mg883,00€1mL*10mM (DMSO)224,00€
