CCR
Os receptores de quimiocinas C-C (CCRs) são um grupo de GPCRs que respondem às quimiocinas, moléculas de sinalização que orientam a migração de células imunológicas para locais de inflamação ou infecção. Os CCRs desempenham papéis cruciais nas respostas imunológicas, inflamação e no desenvolvimento de várias doenças, incluindo distúrbios autoimunes e câncer. A modulação da atividade dos CCRs está sendo explorada como uma estratégia terapêutica para condições como artrite reumatoide, esclerose múltipla e infecção pelo HIV. Na CymitQuimica, oferecemos uma gama de moduladores de CCR de alta qualidade para apoiar sua pesquisa em imunologia, inflamação e desenvolvimento terapêutico.
Produtos da "CCR"
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CCX354
CAS:CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis.Fórmula:C22H22ClN7O2Pureza:99% - 99.28%Cor e Forma:SolidPeso molecular:451.91RS102895 hydrochloride
CAS:RS102895 hydrochloride is a potent antagonist of CCR2(IC50 of 360 nM).Fórmula:C21H22ClF3N2O2Pureza:98.95%Cor e Forma:SolidPeso molecular:426.86MK-0812
CAS:MK-0812 is a dual antagonist of the CCR2 and CCR5 receptors that can alleviate adipose inflammation in ob/ob mice.Fórmula:C24H34F3N3O3Pureza:98%Cor e Forma:SolidPeso molecular:469.54Met-RANTES,human,acetate
Met-RANTES (human) acetate is the acetate salt form of Met-RANTES (human). It acts as an antagonist for CCR1 and CCR5 receptors. This compound inhibits the human chemokines MIP-1α and MIP-1β, with respective IC50 values of 5 and 2 nM. Additionally, Met-RANTES (human) acetate reduces bone destruction and alleviates adjuvant-induced arthritis (AIA) in rats.Cor e Forma:Odour SolidCCR8 agonist 1
CCR8 agonist1 (Compound 2) is an activator of CCR8 and is applicable in studies related to autoimmune diseases.Fórmula:C22H29NO3Cor e Forma:SolidPeso molecular:355.47ML604086
CAS:ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations.Fórmula:C27H32N4O4SPureza:99.91%Cor e Forma:SolidPeso molecular:508.63MK-0812 Succinate
CAS:MK-0812 Succinate is an effective and selective CCR2 antagonist.Fórmula:C28H40F3N3O7Pureza:98.62%Cor e Forma:SolidPeso molecular:587.63CCR2 antagonist 5
CAS:JNJ-41443532: oral hCCR2 antagonist, IC50=37 nM, anti-chemotaxis, treats inflammation & diabetes.Fórmula:C22H25F3N4O3SPureza:98.79%Cor e Forma:SolidPeso molecular:482.52GSK2239633A
CAS:GSK2239633A is an allosteric antagonist of CC-chemokine receptor 4 (CCR4) with a pIC50 of 7.96 for the binding of [125I]-TARC to human CCR4.Fórmula:C24H25ClN4O5S2Pureza:99.78%Cor e Forma:SolidPeso molecular:549.06Ref: TM-T11481
1mg38,00€5mg84,00€10mg125,00€25mg259,00€50mg375,00€100mg545,00€500mgA consultar1mL*10mM (DMSO)93,00€Nifeviroc
CAS:Nifeviroc (TD-0232) is an orally active CCR5 antagonist, useful in HIV-1 infection research.Fórmula:C33H42N4O6Pureza:98.14%Cor e Forma:SolidPeso molecular:590.71CCR2 antagonist 4
CAS:CCR2 antagonist 4 (Teijin compound 1) is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nMFórmula:C21H21ClF3N3O2Pureza:99.63%Cor e Forma:SolidPeso molecular:439.86Ref: TM-T13114
1mg52,00€5mg120,00€10mg188,00€25mg329,00€50mg490,00€100mg697,00€1mL*10mM (DMSO)133,00€AZ084
CAS:AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma.Fórmula:C26H34N4O2Pureza:97.12%Cor e Forma:SolidPeso molecular:434.57Ref: TM-T10425
1mg88,00€5mg170,00€10mg259,00€25mg429,00€50mg605,00€100mg815,00€200mg1.093,00€1mL*10mM (DMSO)182,00€RS 504393
CAS:RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).Fórmula:C25H27N3O3Pureza:98.49% - 98.64%Cor e Forma:SolidPeso molecular:417.5CCR2 antagonist 3
CAS:CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.Fórmula:C17H25FN2O2Pureza:100%Cor e Forma:SolidPeso molecular:308.39Ref: TM-T10712
1mg70,00€5mg156,00€10mg239,00€25mg419,00€50mg562,00€100mg787,00€200mg1.035,00€1mL*10mM (DMSO)170,00€CMPD167
CAS:CMPD167 (MRK-1) is a potent, orally active inhibitor of CCR5 with significant in vitro antiviral efficacy [1].Fórmula:C35H47FN4O2Pureza:98%Cor e Forma:SolidPeso molecular:574.77Cenicriviroc Mesylate
CAS:Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.Fórmula:C42H56N4O7S2Pureza:98%Cor e Forma:SolidPeso molecular:793.05PF-04634817
CAS:PF-0463481: safe, well-tolerated, dual CCR2/CCR5 antagonist for diabetic nephropathy; similar human/rodent CCR2 potency, less rodent CCR5 effect.Fórmula:C25H36F3N5O3Pureza:98%Cor e Forma:SolidPeso molecular:511.58AZD2423
CAS:AZD2423 is a potent, selective, orally bioavailable, and non-competitive CCR2 chemokine receptor negative allosteric modulator and it has an IC50 of 1.2 nM forFórmula:C20H29ClFN5O2Pureza:98%Cor e Forma:SolidPeso molecular:425.93C-021
CAS:C 021 dihydrochloride is a potent CCR4 antagonist.Fórmula:C27H41N5O2Pureza:100.00% - 99.74%Cor e Forma:SolidPeso molecular:467.65Ref: TM-T21870
1mg51,00€2mg71,00€5mg96,00€10mg153,00€25mg303,00€50mg469,00€100mg655,00€1mL*10mM (DMSO)96,00€
