Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Produtos da "Canal TRP/TRPV"
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PF-05105679
CAS:PF-05105679 is a selective TRPM8 antagonist (IC50 = 103 nM). PF-05105679 can be used in research on cold-related pain.Fórmula:C26H21FN2O3Pureza:99.82%Cor e Forma:SolidPeso molecular:428.45Ref: TM-T16483
1mg48,00€2mg65,00€5mg96,00€10mg160,00€25mg305,00€50mg472,00€100mg710,00€200mg938,00€500mg1.444,00€1mL*10mM (DMSO)96,00€Pyr10
CAS:Pyr10, a pyrazole derivative, selectively inhibits TRPC3, not STIM1/Orai1, with IC50 of 0.72 μM in TRPC3-HEK293, and 13.08 μM in BRL-2H3 cells.Fórmula:C18H13F6N3O2SPureza:99.69% - 99.70%Cor e Forma:SolidPeso molecular:449.37IA-Alkyne
CAS:IA-Alkyne: TRPC agonist, cysteine-reactivity probe, potential in respiratory infection study.Fórmula:C8H12INOPureza:99.76%Cor e Forma:SolidPeso molecular:265.09Ref: TM-T15543
1mg59,00€5mg126,00€10mg187,00€25mg264,00€50mg329,00€100mg455,00€1mL*10mM (DMSO)120,00€TRPC6-PAM-C20
CAS:TRPC6-PAM-C20, a selective enhancer for TRPC6, boosts calcium in HEK cells and OAG-related platelet clumping, EC50: 2.37μM.Fórmula:C22H21NO4Pureza:98.16%Cor e Forma:SolidPeso molecular:363.41Pyr3
CAS:Pyr3 selectively blocks TRPC3 channels, reducing Ca2+ influx; it's effective at 700 nM.Fórmula:C16H11Cl3F3N3O3Pureza:99.47%Cor e Forma:SolidPeso molecular:456.63Ref: TM-T16687
1mg35,00€2mg52,00€5mg77,00€10mg97,00€25mg215,00€50mg363,00€100mg512,00€200mg738,00€500mg1.121,00€1mL*10mM (DMSO)86,00€RN-1734
CAS:RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM,5.9 μM,3.2 μM for hTRPV4, mTRPV4 and rTRPV4,respectively)Fórmula:C14H22Cl2N2O2SPureza:99.1% - 99.30%Cor e Forma:SolidPeso molecular:353.31SB-366791
CAS:SB-366791 is a new and selective cinnamide TRPV1 antagonist.Fórmula:C16H14ClNO2Pureza:99.12%Cor e Forma:SolidPeso molecular:287.74TRPM8 antagonist 2
CAS:TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.Fórmula:C26H26N2O2Pureza:98.10%Cor e Forma:SolidPeso molecular:398.5Ref: TM-T5698
1mg35,00€5mg70,00€10mg104,00€25mg170,00€50mg274,00€100mg439,00€200mg632,00€1mL*10mM (DMSO)78,00€NGD-8243
CAS:NGD-8243 (N-[4-(trifluoromethyl)phenyl]-7-[3-(trifluoromethyl)pyridin-2-yl]quinazolin-4-amine) is a TRPV1 inhibitor and can be used in studies for preventionFórmula:C21H12F6N4Pureza:95.26%Cor e Forma:SolidPeso molecular:434.34Vocacapsaicin hydrochloride
CAS:Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.Fórmula:C26H42ClN3O4Pureza:98.51% - 99.94%Cor e Forma:SolidPeso molecular:496.08HC-067047
CAS:HC-067047 is a potent and selective TRPV4 antagonist.Also inhibits the endogenous TRPV4-mediated response to 4α-PDH .Fórmula:C26H28F3N3O2Pureza:99.45% - 99.79%Cor e Forma:SolidPeso molecular:471.51SAR7334
CAS:SAR7334 (TRCP6-IN-1) is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).Fórmula:C21H22ClN3OPureza:99.62% - 99.71%Cor e Forma:SolidPeso molecular:367.87Ref: TM-T12849
1mg71,00€5mg160,00€10mg250,00€25mg401,00€50mg567,00€100mg707,00€200mg938,00€1mL*10mM (DMSO)170,00€Asivatrep
CAS:Asivatrep (PAC14028) is a selective and potent antagonist of transient receptor potential vanilloid subtype 1 (TRPV1) for the study of atopic dermatitis.Fórmula:C21H22F5N3O3SPureza:95.13%Cor e Forma:SolidPeso molecular:491.48WS-12
CAS:WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)Fórmula:C18H27NO2Pureza:99.99%Cor e Forma:Whitish To White Solid CrystallinePeso molecular:289.41ABT-239
CAS:ABT-239 is a novel, highly efficacious antagonist belonging to the non-imidazole class of histamine H3 receptor (H3R) antagonists.Fórmula:C22H22N2OPureza:100%Cor e Forma:SolidPeso molecular:330.42Ref: TM-T14087
1mg48,00€5mg96,00€10mg160,00€25mg313,00€50mg470,00€100mg660,00€200mg917,00€1mL*10mM (DMSO)96,00€JNJ-28583113
CAS:JNJ-28583113 is a TRPM2 antagonist, inducing phosphorylation of GSK3α and β subunits, protecting cells from oxidative stress-induced cell death.Fórmula:C19H21F3N2O2Pureza:98.57%Cor e Forma:SolidPeso molecular:366.38Ref: TM-T74779
1mg92,00€5mg215,00€10mg321,00€25mg494,00€50mg856,00€100mg1.478,00€200mg1.931,00€1mL*10mM (DMSO)225,00€PF-04745637
CAS:PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM[1].Fórmula:C27H32ClF3N2O2Pureza:97.91% - 99.3%Cor e Forma:SolidPeso molecular:509Ref: TM-T64337
1mg73,00€5mg145,00€10mg197,00€25mg333,00€50mg475,00€100mg655,00€200mg882,00€1mL*10mM (DMSO)163,00€MSP3
CAS:MSP3 is an agonist of TRPV1 (EC50 = 0.87 μM) and shows antinociceptive and neuroprotective effects.Fórmula:C16H19NO3SPureza:99.46%Cor e Forma:SolidPeso molecular:305.39Ref: TM-T28118
2mg34,00€5mg52,00€10mg85,00€25mg170,00€50mg255,00€100mg378,00€200mg533,00€1mL*10mM (DMSO)74,00€M084
CAS:M084 (N-Butyl-1H-benzimidazol-2-amine) is a blocker of TRPC4/5 channel, with antidepressant and anxiolytic effects.Fórmula:C11H15N3Pureza:98.13%Cor e Forma:SolidPeso molecular:189.26Ref: TM-T8607
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)145,00€MDR-652
CAS:MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM forFórmula:C22H23ClFN3O2SPureza:99.96%Cor e Forma:SolidPeso molecular:447.95Ref: TM-T22360
1mg66,00€5mg144,00€10mg205,00€25mg369,00€50mg558,00€100mg800,00€200mg1.074,00€1mL*10mM (DMSO)157,00€
