Canal TRP/TRPV
Os canais TRP (Potencial do Receptor Transitório), incluindo a subfamília TRPV, são um grupo de canais iônicos envolvidos em vários processos sensoriais, como sensação de temperatura, percepção da dor e osmorregulação. Os canais TRP são amplamente expressos em diferentes tecidos e desempenham um papel nas respostas fisiológicas aos estímulos ambientais. Os canais TRPV, em particular, estão envolvidos na detecção de mudanças de temperatura e estão implicados em condições como dor crônica, inflamação e câncer. Na CymitQuimica, oferecemos uma gama abrangente de moduladores de canais TRP/TRPV para apoiar sua pesquisa em biologia sensorial, manejo da dor e transdução de sinais.
Produtos da "Canal TRP/TRPV"
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BI-749327
CAS:BI-749327 is a high selectivity and orally bioavailable antagonist of TRPC6 (IC50s: 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6).Fórmula:C23H21F3N4O2Pureza:99.68%Cor e Forma:SolidPeso molecular:442.43Ref: TM-T10537
1mg133,00€2mg177,00€5mg274,00€10mg432,00€25mg630,00€50mg825,00€100mg1.103,00€500mg2.205,00€1mL*10mM (DMSO)301,00€AM12
CAS:AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).Fórmula:C15H9BrO5Pureza:98%Cor e Forma:SolidPeso molecular:349.13BTD
CAS:BTD is a TRPC5 activator that activates heteromeric channel complexes composed of TRPC5 and its closest relatives TRPC1 or TRPC4.Fórmula:C24H33N3O4SCor e Forma:SolidPeso molecular:459.6TRPM4 inhibitor 8
CAS:TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.Fórmula:C11H17BrN2Pureza:97%Cor e Forma:SolidPeso molecular:257.17Ref: TM-T9776
5mg47,00€10mg65,00€25mg96,00€50mg180,00€100mg283,00€200mg424,00€500mg697,00€1mL*10mM (DMSO)50,00€AC1903
CAS:AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.Fórmula:C19H17N3OPureza:98.45%Cor e Forma:SolidPeso molecular:303.36Linoleoyl Ethanolamide
CAS:Linoleoyl Ethanolamide is an endocannabinoid agent.Fórmula:C20H37NO2Pureza:99.97%Cor e Forma:SolidPeso molecular:323.51Ref: TM-T8425
1mg35,00€5mg67,00€10mg90,00€25mg164,00€50mg239,00€100mg348,00€200mg522,00€1mL*10mM (DMSO)85,00€BCTC
CAS:BCTC is a potent TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 (IC50 of 35 and 6 nM, respectively)Fórmula:C20H25ClN4OPureza:99.21%Cor e Forma:SolidPeso molecular:372.89N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride
CAS:N4-benzyl-N2-methylquinazoline-2,4-diamine hydrochloride is an inhibitor of TRPC4.Fórmula:C16H17ClN4Pureza:99.25%Cor e Forma:SolidPeso molecular:300.79Ref: TM-T8565
1mg88,00€5mg170,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)170,00€RQ-00203078
CAS:RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.Fórmula:C21H13ClF6N2O5SPureza:98% - 99.17%Cor e Forma:SolidPeso molecular:554.85cim0216
CAS:CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.Fórmula:C21H21N3O2Pureza:99.87%Cor e Forma:SolidPeso molecular:347.41Ref: TM-T9263
1mg47,00€2mg59,00€5mg92,00€10mg145,00€25mg298,00€50mg465,00€100mg702,00€500mg1.454,00€1mL*10mM (DMSO)92,00€AMG 517
CAS:AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM) and heat activation (IC50: 1.3 nM) of TRPV1Fórmula:C20H13F3N4O2SPureza:99.77% - 99.85%Cor e Forma:SolidPeso molecular:430.4GSK2798745
CAS:GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4).Fórmula:C25H28N6O3Cor e Forma:SolidPeso molecular:460.53MK6-83
CAS:MK6-83 is the transient receptor potential channel ML3 agonist.Fórmula:C16H20N2O2S2Pureza:99.71%Cor e Forma:SolidPeso molecular:336.47TRPV4 agonist-1 free base
CAS:TRPV4 agonist-1 free base (OUN67600) is an agonist of transient receptor potential vanilloid 4 (TRPV4;EC50 of 60 nM, in the hTRPV4 Ca2+ assay).Fórmula:C25H22F2N4O2Pureza:99.79%Cor e Forma:SolidPeso molecular:448.46ABT 102
CAS:ABT 102 (CHEMBL398338) is a selective antagonist of transient receptor potential vanilloid 1 (TRPV1) receptor.Fórmula:C21H24N4OPureza:98.38% - 99.72%Cor e Forma:SolidPeso molecular:348.44Ref: TM-T29522
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)259,00€(Z)-Capsaicin
CAS:(Z)-Capsaicin (Zucapsaicin) is a medication used to treat osteoarthritis of the knee and Others neuropathic pain.(Z)-Capsaicin is a synthetic cis isomer ofFórmula:C18H27NO3Pureza:97.33% - 99.67%Cor e Forma:SolidPeso molecular:305.41Resolvin D2
CAS:Resolvin D2 (RvD2) is a TRPV1 inhibitor and pro-ablative mediator with anti-inflammatory, anti-infective and pro-ablative effects.Fórmula:C22H32O5Pureza:98%Cor e Forma:SolidPeso molecular:376.49JNJ-17203212
CAS:JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).Fórmula:C17H15F6N5OPureza:99.18%Cor e Forma:SolidPeso molecular:419.32AP 18
CAS:AP-18 is a potent and selective TRPA1 inhibitor.Fórmula:C11H12ClNOPureza:99.85% - 99.87%Cor e Forma:SolidPeso molecular:209.67Ref: TM-T21543
2mg35,00€5mg50,00€10mg73,00€25mg140,00€50mg215,00€100mg338,00€500mg723,00€1mL*10mM (DMSO)50,00€TRPM8 antagonist WS-3
CAS:TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).Fórmula:C13H25NOPureza:97.64%Cor e Forma:DrypowderPeso molecular:211.34
