PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Produtos da "PDE"
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Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Fórmula:C21H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:405.45NSP-805
CAS:NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.Fórmula:C17H19N3O2Pureza:99.10%Cor e Forma:SolidPeso molecular:297.35Ref: TM-T12267
1mg52,00€5mg116,00€10mg187,00€25mg325,00€50mg467,00€100mg645,00€200mg872,00€1mL*10mM (DMSO)128,00€MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Fórmula:C19H22N6OSPureza:100% - 99.67%Cor e Forma:SolidPeso molecular:382.48Tovinontrine
CAS:Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.Fórmula:C21H26N6O2Pureza:98.14%Cor e Forma:SolidPeso molecular:394.47FCPR03
CAS:FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively.Fórmula:C15H19F2NO3Pureza:100.00%Cor e Forma:SolidPeso molecular:299.31Ref: TM-T39341
1mg52,00€2mg75,00€5mg116,00€10mg183,00€25mg311,00€50mg444,00€100mg605,00€200mg815,00€1mL*10mM (DMSO)128,00€T-0156
CAS:T-0156 is a PEG5 inhibitor that inhibits the hydrolysis of cyclic guanosine monophosphate (cGMP) with low affinity for PDE6, PDE1, PDE2, PDE3 and PDE4.Fórmula:C31H29N5O7Pureza:100% - 98.42%Cor e Forma:SoildPeso molecular:583.59Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C30H39ClN6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:647.25Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Fórmula:C13H12N4OPureza:98.56% - 99.36%Cor e Forma:SolidPeso molecular:240.26Imazodan hydrochloride
CAS:Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.Fórmula:C13H13ClN4OPureza:99.84%Cor e Forma:SolidPeso molecular:276.72Roflumilast
CAS:Roflumilast (APTA 2217) is an orally available, long-acting inhibitor of phosphodiesterase (PDE) type 4 (PDE4), with anti-inflammatory and potentialFórmula:C17H14Cl2F2N2O3Pureza:100.00% - 99.76%Cor e Forma:SolidPeso molecular:403.21BRL-50481
CAS:BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.Fórmula:C9H12N2O4SPureza:99.66%Cor e Forma:SolidPeso molecular:244.27Autotaxin-IN-3
CAS:Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.Fórmula:C22H21N9O2Pureza:98.49% - 99.21%Cor e Forma:SolidPeso molecular:443.46Ref: TM-T10415
2mg46,00€5mg70,00€10mg101,00€25mg183,00€50mg284,00€100mg455,00€200mg625,00€1mL*10mM (DMSO)78,00€GEBR-7b
CAS:GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) is a phosphodiesterase-4 (PDE4) inhibitor.Fórmula:C13H16O3Pureza:99.54%Cor e Forma:SolidPeso molecular:220.26PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Fórmula:C25H21N3O6SPureza:98%Cor e Forma:SolidPeso molecular:491.52Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Fórmula:C23H33N7O5SPureza:98.25% - 99.06%Cor e Forma:SolidPeso molecular:519.62Ref: TM-T15381
1mg185,00€5mg415,00€10mg613,00€25mg938,00€50mg1.311,00€100mg1.768,00€1mL*10mM (DMSO)520,00€Pumafentrine
CAS:Pumafentrine(BY 343) is a dual PDE3/PDE4 inhibitor that reduces clinical scores and TNF expression in experimental colitis in mice.Fórmula:C29H39N3O3Pureza:99.79%Cor e Forma:SolidPeso molecular:477.64PF-05085727
CAS:PF-05085727 inhibits PDE2A >4,000-fold selectivity over PDE1 and PDE3-11.Fórmula:C20H18F3N7Pureza:98%Cor e Forma:SolidPeso molecular:413.4OPC18750 HCl
CAS:OPC18750 HCl is a phosphodiesterase inhibitor with positive inotropic effects that can be used to study asthma, cancer, diabetes, and psychiatric disorders.Fórmula:C20H23ClN2O4Pureza:98.92%Cor e Forma:SoildPeso molecular:390.86Ref: TM-T83974
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€1mL*10mM (DMSO)47,00€[11C]MP 10
CAS:[11C]MP 10 (PF-2545920), a specific and effective PDE10A inhibitor (IC50=0.37 nM), is with more than1000-fold specificity activity over the PDE.Fórmula:C25H20N4OPureza:99.87%Cor e Forma:SolidPeso molecular:391.45YM976
CAS:YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)Fórmula:C17H16ClN3OPureza:99.84%Cor e Forma:SolidPeso molecular:313.78
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