PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Produtos da "PDE"
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PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Fórmula:C20H28N8O4SPureza:100%Cor e Forma:SolidPeso molecular:476.55K134
CAS:K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.Fórmula:C22H29N3O4Pureza:98%Cor e Forma:SolidPeso molecular:399.48WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Fórmula:C23H28N4O4Pureza:98.63%Cor e Forma:SolidPeso molecular:424.49Ref: TM-T13331
1mg77,00€5mg158,00€10mg225,00€25mg338,00€50mg475,00€100mg638,00€200mg845,00€1mL*10mM (DMSO)170,00€Avanafil
CAS:Avanafil (TA1790) is a selective inhibitor of phosphodiesterase type 5 (PDE5) and is used as therapy of erectile dysfunction.Fórmula:C23H26ClN7O3Pureza:98% - 99.03%Cor e Forma:White SolidPeso molecular:483.95Cilomilast
CAS:Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3.Fórmula:C20H25NO4Pureza:97.37% - 99.43%Cor e Forma:White SolidPeso molecular:343.42PF-04957325
CAS:PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.Fórmula:C14H15F3N8OSPureza:99.02%Cor e Forma:SolidPeso molecular:400.38Ref: TM-T12422
1mg137,00€5mg235,00€10mg354,00€25mg610,00€50mg885,00€100mg1.320,00€1mL*10mM (DMSO)207,00€MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Cor e Forma:SolidPeso molecular:441.71Ref: TM-T12103
1mg145,00€2mg207,00€5mg354,00€10mg528,00€25mg852,00€50mg1.159,00€100mg1.568,00€500mg3.125,00€1mL*10mM (DMSO)378,00€AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Fórmula:C25H23N5O3Pureza:99.35%Cor e Forma:SolidPeso molecular:441.48Ref: TM-T14217
1mg35,00€2mg47,00€5mg73,00€10mg105,00€25mgA consultar50mgA consultar1mL*10mM (DMSO)82,00€Vardenafil hydrochloride trihydrate
CAS:Vardenafil hydrochloride trihydrate (BAY38-9456) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.Fórmula:C23H32N6O4S·HCl·3H2OPureza:99.77%Cor e Forma:SolidPeso molecular:579.11Ref: TM-T4097
5mg47,00€10mg70,00€25mg125,00€50mg187,00€100mg298,00€200mg444,00€500mg715,00€1mL*10mM (DMSO)63,00€Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Fórmula:C17H17N3O3SPureza:97.52%Cor e Forma:SolidPeso molecular:343.4Ref: TM-T7888
1mg133,00€5mg274,00€10mg432,00€25mg715,00€50mg1.008,00€100mg1.359,00€1mL*10mM (DMSO)303,00€N-Ethyl tadalafil
CAS:N-Ethyl tadalafil (NEthyl tadalafil) is a PDE inhibitor used in the study of cardiovascular disease.Fórmula:C23H21N3O4Pureza:99.58%Cor e Forma:SolidPeso molecular:403.43BI 1015550
CAS:Nerandomilast (BI 1015550) is an orally active PDE4B inhibitor with IC50 of 7.2 nM.Cost-effective and quality-assured.Fórmula:C20H25ClN6O2SPureza:100% - 99.71%Cor e Forma:SoildPeso molecular:448.97Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C32H40ClF3N6O6S2Pureza:98%Cor e Forma:SolidPeso molecular:761.28Carbodenafil
CAS:Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).Fórmula:C24H32N6O3Pureza:98.96%Cor e Forma:SolidPeso molecular:452.55Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C30H29N9O2Pureza:98%Cor e Forma:SolidPeso molecular:547.61Enpp/Carbonic anhydrase-IN-1
CAS:Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent inhibitor of Enpp and carbonic anhydrase.Fórmula:C23H25NO4SPureza:100%Cor e Forma:SoildPeso molecular:411.51GSK356278
CAS:GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.Fórmula:C21H25N7O2SPureza:99.43% - 99.79%Cor e Forma:SolidPeso molecular:439.53CP671305
CAS:CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.Fórmula:C23H19FN2O7Pureza:99.39%Cor e Forma:SolidPeso molecular:454.42,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide
CAS:2,5-dichloro-4-(difluoromethoxy)-N,N-dimethylbenzene-1-sulfonamide is a PDE inhibitor.Fórmula:C9H9Cl2F2NO3SPureza:98.60%Cor e Forma:SolidPeso molecular:320.14Ref: TM-T50062
1mg84,00€2mg111,00€5mg172,00€10mg249,00€25mg426,00€50mg627,00€100mg893,00€1mL*10mM (DMSO)172,00€ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Fórmula:C22H19N3O4Pureza:98%Cor e Forma:SolidPeso molecular:389.4
