PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Produtos da "PDE"
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Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Fórmula:C21H15ClF3NO2Pureza:98.20%Cor e Forma:SolidPeso molecular:405.8Ref: TM-T10590
1mg70,00€5mg135,00€10mg245,00€25mg409,00€50mg562,00€100mg780,00€200mg1.026,00€1mL*10mM (DMSO)149,00€Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Fórmula:C23H24F2N2O5Pureza:99.04%Cor e Forma:SolidPeso molecular:446.44Ref: TM-T27172
1mg69,00€5mg149,00€10mg235,00€25mg469,00€50mg753,00€100mg1.216,00€1mL*10mM (DMSO)164,00€Vardenafil hydrochloride
CAS:Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With DiabetesFórmula:C23H33ClN6O4SPureza:99.76% - 99.86%Cor e Forma:White To Off-White Cyrstalline SolidPeso molecular:525.06TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Fórmula:C26H19F3N4OPureza:98.48%Cor e Forma:SolidPeso molecular:460.45Ref: TM-T13189
1mg92,00€2mg120,00€5mg187,00€10mg279,00€25mg487,00€50mg705,00€100mg998,00€500mg1.882,00€1mL*10mM (DMSO)188,00€Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Fórmula:C30H30Cl2F2N2O8SPureza:98.3%Cor e Forma:SolidPeso molecular:687.54PDE5-IN-9
CAS:WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.Fórmula:C18H14N4SPureza:100%Cor e Forma:SolidPeso molecular:318.4K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).Fórmula:C25H26FN5O2Pureza:99.48%Cor e Forma:SolidPeso molecular:447.5Isomazole
CAS:Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.Fórmula:C14H13N3O2SPureza:99.12%Cor e Forma:SolidPeso molecular:287.34Cilostazol
CAS:Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.Fórmula:C20H27N5O2Pureza:99.58% - 99.90%Cor e Forma:Off-White SolidPeso molecular:369.46Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Fórmula:C15H15N3OPureza:99.11%Cor e Forma:SolidPeso molecular:253.3EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Fórmula:C22H23N3O4SPureza:98% - 99.38%Cor e Forma:SolidPeso molecular:425.5MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Fórmula:C25H18N4O3Pureza:99.29%Cor e Forma:SolidPeso molecular:422.44Anagrelide hydrochloride
CAS:Anagrelide hydrochloride (BL4162A) serves as a treatment for essential thrombocytosis.Fórmula:C10H7Cl2N3O·HClPureza:99.58%Cor e Forma:Off-White PowderPeso molecular:292.55Oglemilast
CAS:Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Fórmula:C20H13Cl2F2N3O5SPureza:98.11%Cor e Forma:SolidPeso molecular:516.3Anti-ALDH7A1 Antibody (1G435)
Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.Cor e Forma:Odour LiquidTAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Fórmula:C19H18F4N4O5Pureza:98%Cor e Forma:SolidPeso molecular:458.36Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Fórmula:C14H10BNO3Pureza:99.70%Cor e Forma:SolidPeso molecular:251.05Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Fórmula:C21H15Cl2F2N3O2SPureza:98.84%Cor e Forma:SolidPeso molecular:482.33Ref: TM-T63190
1mg77,00€5mg170,00€10mg248,00€25mg444,00€50mg662,00€100mg929,00€200mg1.225,00€1mL*10mM (DMSO)170,00€Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Fórmula:C14H18N2OPureza:99.34% - 99.94%Cor e Forma:White SolidPeso molecular:230.31Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Fórmula:C15H22ClN5O4SPureza:100%Cor e Forma:SoildPeso molecular:403.88
