PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Produtos da "PDE"
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Sildenafil Mesylate
CAS:Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.Fórmula:C22H30N6O4S·xCH4O3SPureza:99.84%Cor e Forma:SolidPeso molecular:570.68Roflumilast N-oxide
CAS:Roflumilast N-oxide is an inhibitor of PDE type 4.Fórmula:C17H14Cl2F2N2O4Pureza:99.55% - 99.65%Cor e Forma:SolidPeso molecular:419.21Ref: TM-T4462
1mg35,00€2mg52,00€5mg74,00€10mg99,00€25mg170,00€50mg274,00€100mg350,00€500mg840,00€1mL*10mM (DMSO)69,00€PAT-048
CAS:PAT-048 is an effective and selective autotaxin inhibitor.Fórmula:C22H18ClF2N3O2SPureza:98%Cor e Forma:SolidPeso molecular:461.912-(Hydroxymethyl)pyridine
CAS:2-(Hydroxymethyl)pyridine (Piconol) is an intermediate for the synthesis of the stimulant laxative bisacodyl, and as a pyridinol with hypoglycemic activity.Fórmula:C6H7NOPureza:99.79%Cor e Forma:Clear Light Yellow To Orange Liquid LiquidPeso molecular:109.13Zaprinast
CAS:Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist.Fórmula:C13H13N5O2Pureza:99.73% - 99.77%Cor e Forma:White To Off White PowderPeso molecular:271.27Cilostamide
CAS:Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)Fórmula:C20H26N2O3Pureza:98.87%Cor e Forma:White To Off-White SolidPeso molecular:342.43Irsogladine
CAS:Irsogladine (Dicloguamine) is an anti-ulcer agent that promotes gap junction intercellular communication via M1 muscarinic acetylcholine receptor binding.Fórmula:C9H7Cl2N5Pureza:99.74% - 99.91%Cor e Forma:White Or Colorless Crystal Or Crystalline Powder Odorless Slightly BitterPeso molecular:256.09uk-50001
CAS:UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.Fórmula:C26H24F3N3O4Pureza:99.90%Cor e Forma:SolidPeso molecular:499.48Ref: TM-T67815
1mg159,00€5mg380,00€10mg570,00€25mg912,00€50mg1.216,00€100mg1.663,00€500mg3.315,00€1mL*10mM (DMSO)470,00€AWD 12-281
CAS:AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).Fórmula:C22H14Cl2FN3O3Pureza:99.55% - 99.95%Cor e Forma:SolidPeso molecular:458.27Mopidamol
CAS:Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimentalFórmula:C19H31N7O4Pureza:99.42% - 99.51%Cor e Forma:SolidPeso molecular:421.49Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Fórmula:C30H40Cl2N6O4S2Pureza:98%Cor e Forma:SolidPeso molecular:683.71MBCQ
CAS:MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.Fórmula:C16H12ClN3O2Pureza:99.45%Cor e Forma:SolidPeso molecular:313.74Ref: TM-T21965
5mg47,00€10mg80,00€25mg145,00€50mg233,00€100mg335,00€200mg467,00€1mL*10mM (DMSO)49,00€Tofimilast
CAS:Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.Fórmula:C18H21N5SPureza:99.94%Cor e Forma:SolidPeso molecular:339.46Mirodenafil
CAS:Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.Fórmula:C26H37N5O5SPureza:99.89%Cor e Forma:SolidPeso molecular:531.67Ref: TM-T16079
2mg35,00€5mg52,00€10mg79,00€25mg134,00€50mg210,00€100mg338,00€200mg497,00€1mL*10mM (DMSO)60,00€ONO-8430506
CAS:ONO-8430506 is an orally available, potent autotaxin (ATX)/ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.Fórmula:C27H28FN3O3Pureza:97.05%Cor e Forma:SolidPeso molecular:461.53Ref: TM-T38759
1mg156,00€5mg368,00€10mg509,00€25mg770,00€50mg1.035,00€100mg1.396,00€200mg1.882,00€1mL*10mM (DMSO)409,00€Dipyridamole
CAS:Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.Fórmula:C24H40N8O4Pureza:99.47% - 99.84%Cor e Forma:SolidPeso molecular:504.63Z-HA155
CAS:Z-HA155 (CS-963) selectively and potently inhibits autotaxin with an IC50 of 5.7 nM.Fórmula:C24H19BFNO5SPureza:98.28%Cor e Forma:SolidPeso molecular:463.29Ref: TM-T11533
1mg49,00€2mg65,00€5mg97,00€10mg154,00€25mg298,00€50mg487,00€100mg692,00€1mL*10mM (DMSO)106,00€Pimobendan
CAS:Pimobendan (UD-CG 115 BS) is a selective inhibitor of PDE3 (IC50: 0.32 μM).Fórmula:C19H18N4O2Pureza:99.91%Cor e Forma:SolidPeso molecular:334.37Ref: TM-T1708
2mg38,00€5mg60,00€10mg87,00€25mg162,00€50mg274,00€100mg406,00€500mg920,00€1mL*10mM (DMSO)66,00€Sulmazole
CAS:Sulmazole (AR-L 115-BS) is a small molecule Sulmazole is a small molecule cGMP-PDE inhibitor.Sulmazole is a competitive inhibitor of A1 adenosine receptors.Fórmula:C14H13N3O2SPureza:99.64%Cor e Forma:SolidPeso molecular:287.34D159687
CAS:D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant benefit.Fórmula:C21H19ClN2O2Pureza:97.57%Cor e Forma:SolidPeso molecular:366.84
