PDE
As fosfodiesterases (PDEs) são enzimas que hidrolisam nucleotídeos cíclicos, como AMPc e GMPc, em suas formas inativas, desempenhando um papel crucial na regulação das vias de sinalização intracelular. Inibidores de PDE são utilizados no tratamento de diversas condições, incluindo doenças cardiovasculares, disfunção erétil e distúrbios respiratórios, devido à sua capacidade de modular os níveis de nucleotídeos cíclicos. Na CymitQuimica, oferecemos uma variedade de inibidores de PDE para apoiar sua pesquisa em sinalização celular, farmacologia e desenvolvimento terapêutico.
Produtos da "PDE"
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Carbazeran
CAS:Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.Fórmula:C18H24N4O4Pureza:97.28%Cor e Forma:SolidPeso molecular:360.41Autotaxin modulator 1
CAS:Autotaxin modulator 1 is a new modulator of Autotaxin.Fórmula:C28H31F6NO3Cor e Forma:SolidPeso molecular:543.54Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Fórmula:C16H17N5O2Pureza:99.93%Cor e Forma:SolidPeso molecular:311.34Ref: TM-T8515
1mg38,00€2mg50,00€5mg81,00€10mg119,00€25mg188,00€50mg350,00€100mg522,00€200mg748,00€1mL*10mM (DMSO)89,00€PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFórmula:C20H23ClN4O2Pureza:98.57%Cor e Forma:SolidPeso molecular:386.88Ref: TM-T10201
1mg341,00€5mg723,00€10mg969,00€25mg1.454,00€50mg1.948,00€100mg2.632,00€1mL*10mM (DMSO)815,00€ALDH7A1 Protein, Human, Recombinant (His)
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.Cor e Forma:Lyophilized PowderPeso molecular:56 kDa (predicted); 56 kDa (reducing conditions)Anti-ALDH7A1 Antibody (6G475)
Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.Cor e Forma:Odour LiquidRS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Fórmula:C19H13N5O4Pureza:98.98%Cor e Forma:SolidPeso molecular:375.34Ref: TM-T9239
1mg88,00€5mg172,00€10mg259,00€25mg425,00€50mg598,00€100mg810,00€200mg1.074,00€1mL*10mM (DMSO)187,00€ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Fórmula:C22H18ClF3N6OPureza:99.23%Cor e Forma:SolidPeso molecular:474.87Ref: TM-T10409
1mg64,00€5mg140,00€10mg219,00€25mg373,00€50mg510,00€100mg695,00€200mg937,00€1mL*10mM (DMSO)145,00€PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Fórmula:C14H11ClN2O3SPureza:98%Cor e Forma:SolidPeso molecular:322.77IBMX
CAS:IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μMFórmula:C10H14N4O2Pureza:100% - 99.99%Cor e Forma:Off-WhitePeso molecular:222.24GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFórmula:C27H26N4O5SPureza:99.52% - 99.66%Cor e Forma:SolidPeso molecular:518.58PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Fórmula:C17H23FN6O2Pureza:100%Cor e Forma:SolidPeso molecular:362.4Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C22H21N9O2Pureza:98%Cor e Forma:SolidPeso molecular:443.46PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Fórmula:C18H20ClN5OPureza:98.75%Cor e Forma:SolidPeso molecular:357.84Ref: TM-T28352
1mg39,00€5mg73,00€10mg94,00€25mg153,00€50mg219,00€100mg325,00€200mg465,00€1mL*10mM (DMSO)84,00€Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Fórmula:C16H14N4OPureza:100% - 99.61%Cor e Forma:SolidPeso molecular:278.31Ref: TM-T23638
1mg115,00€2mg172,00€5mg255,00€10mg375,00€25mg562,00€50mg792,00€100mg1.064,00€500mgA consultar1mL*10mM (DMSO)240,00€PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Fórmula:C19H17ClN2O2Pureza:100%Cor e Forma:SolidPeso molecular:340.8Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Fórmula:C26H24N4O5Pureza:97.03% - 99.29%Cor e Forma:SolidPeso molecular:472.49Ref: TM-T3987
1mg34,00€2mg47,00€5mg70,00€10mg96,00€25mg170,00€50mg298,00€100mg430,00€200mg607,00€1mL*10mM (DMSO)71,00€HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Fórmula:C24H19BFNO5SPureza:100% - ≥95%Cor e Forma:SolidPeso molecular:463.29Ref: TM-T2646
2mg39,00€5mg57,00€10mg93,00€25mg145,00€50mg235,00€100mg351,00€200mg528,00€1mL*10mM (DMSO)58,00€ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Fórmula:C9H13N5OPureza:99.02%Cor e Forma:White SolidPeso molecular:207.23PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Fórmula:C19H18ClN3O2SPureza:99.37%Cor e Forma:SolidPeso molecular:387.88Ref: TM-T36832
1mg37,00€5mg79,00€10mg111,00€25mg216,00€50mg354,00€100mg567,00€500mg1.198,00€1mL*10mM (DMSO)87,00€
