GluR
Inibidores do Receptor de Glutamato são compostos que bloqueiam a atividade dos receptores de glutamato, os principais receptores de neurotransmissores excitatórios no cérebro. Esses receptores desempenham um papel crucial na transmissão sináptica, plasticidade, aprendizado e memória. A desregulação da sinalização do glutamato está associada a vários distúrbios neurológicos, como epilepsia, AVC e doenças neurodegenerativas. Os inibidores dos receptores de glutamato são essenciais para investigar os mecanismos de excitotoxicidade e desenvolver estratégias neuroprotetoras. Na CymitQuimica, oferecemos uma gama de inibidores de receptores de glutamato para apoiar sua pesquisa em função sináptica, neuroproteção e distúrbios cognitivos.
Produtos da "GluR"
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ADX88178
CAS:ADX88178 is a potent positive allosteric modulator for metabotropic glutamate receptor 4 (mGluR4) with EC50 of 4 nM for human mGluR4.Fórmula:C12H12N6SPureza:99.55%Cor e Forma:SolidPeso molecular:272.33Ref: TM-T4500
2mg38,00€5mg58,00€10mg96,00€25mg156,00€50mg243,00€100mg354,00€200mg505,00€1mL*10mM (DMSO)60,00€LY392098
CAS:LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system.Fórmula:C18H22FNO2SPureza:99.85%Cor e Forma:SolidPeso molecular:335.44Ref: TM-T27951
1mg42,00€5mg87,00€10mg140,00€25mg226,00€50mg324,00€100mg437,00€200mg605,00€1mL*10mM (DMSO)92,00€NS 1209
CAS:NS 1209 (SPD 502) is a AMPA receptor antagonist.Fórmula:C24H27N4NaO7SPureza:98%Cor e Forma:SolidPeso molecular:538.55PHCCC
CAS:PHCCC is a Group I mGluR antagonist and enhances mGluR4 function; also blocks mGluR2/8.Fórmula:C17H14N2O3Pureza:99.31%Cor e Forma:SolidPeso molecular:294.3(S)-3,4-DCPG HCl
(S)-3,4-DCPG HCl is a selective mGluR8a agonist, impacting AV12-664 cells with an EC50 of 31 nM.Fórmula:C10H10ClNO6Pureza:99.06% - 99.90%Cor e Forma:SoildPeso molecular:275.64Ref: TM-T23288L
1mg183,00€5mg462,00€10mg660,00€25mg1.035,00€50mg1.415,00€100mg1.872,00€500mg3.763,00€1mL*10mM (DMSO)415,00€Dasolampanel
CAS:Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.Fórmula:C17H20ClN5O3Pureza:99%Cor e Forma:SolidPeso molecular:377.83VU0360172
CAS:VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).Fórmula:C18H15FN2OPureza:99.65%Cor e Forma:SolidPeso molecular:294.32Ref: TM-T29126
1mg57,00€5mg120,00€10mg187,00€25mg376,00€50mg588,00€100mg833,00€1mL*10mM (DMSO)115,00€XAP044
CAS:XAP044 blocks mGlu7, inhibiting long-term potentiation in mouse brain with a half-maximal effect at 88nm.Fórmula:C15H9IO4Pureza:97.41%Cor e Forma:SolidPeso molecular:380.13Ref: TM-T21995
1mg62,00€2mg87,00€5mg113,00€10mg207,00€25mg369,00€50mg557,00€100mg797,00€1mL*10mM (DMSO)155,00€DHPG
CAS:DHPG is a potent Group I mGluR agonist; doesn't affect Group II/III; linked to phospholipase D.Fórmula:C8H9NO4Pureza:99.55%Cor e Forma:SolidPeso molecular:183.16VU0361737
CAS:VU0361737 (ML-128) is a mGlu4 PAM; EC50 is 240 nM (human) and 110 nM (rat), weak at mGlu5/8, inactive at mGlu1/2/3/6/7, CNS-penetrant.Fórmula:C13H11ClN2O2Pureza:99.09% - 99.86%Cor e Forma:SolidPeso molecular:262.69Philanthotoxin 74 dihydrochloride
CAS:Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1.Fórmula:C24H44Cl2N4O3Pureza:98.6%Cor e Forma:SolidPeso molecular:507.54CNQX
CAS:CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively)Fórmula:C9H4N4O4Pureza:99.70%Cor e Forma:Pale Yellow SolidPeso molecular:232.15Ro 67-7476
CAS:Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors.Fórmula:C17H18FNO2SPureza:99.48%Cor e Forma:SolidPeso molecular:319.39Ref: TM-T3478
1mg35,00€2mg50,00€5mg93,00€10mg131,00€25mg258,00€50mg465,00€100mg680,00€1mL*10mM (DMSO)82,00€JNJ-46281222
CAS:JNJ-46281222: mGlu2-selective, potent PAM, Kd = 1.7 nM, pEC50 = 7.71.Fórmula:C23H25F3N4Cor e Forma:SolidPeso molecular:414.47Ref: TM-T8862
1mg37,00€5mg80,00€10mg116,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)93,00€IDRA-21
CAS:IDRA-21 is a positive AMPA receptor modulator.Fórmula:C8H9ClN2O2SPureza:99.73%Cor e Forma:SolidPeso molecular:232.69DMeOB
CAS:DMeOB (3,3'-Dimethoxybenzaldazine) is a negative regulator with mGluR5 agonist activity and is used in the study of neurological disorders.Fórmula:C16H16N2O2Pureza:98.34%Cor e Forma:SolidPeso molecular:268.31Ref: TM-T22736
1mg35,00€5mg70,00€10mg104,00€25mg202,00€50mg311,00€100mg472,00€500mg1.017,00€1mL*10mM (DMSO)85,00€JNJ-55511118
CAS:JNJ-55511118 is a TARP γ8 allosteric modulator with anticonvulsant activity, which can be used in research on chronic operant alcohol self-administration.Fórmula:C14H8ClF3N2O2Cor e Forma:SolidPeso molecular:328.67Pomaglumetad methionil hydrochloride
CAS:LY2140023 hydrochloride: oral methionine prodrug of LY404039, a selective mGlu2/3 agonist, studied for schizophrenia.Fórmula:C12H19ClN2O7S2Pureza:99.01%Cor e Forma:SolidPeso molecular:402.87Basimglurant
CAS:Basimglurant (CTEP Derivative) is a potent, selective and orally available modulator of mGlu5 negative allosteric(Kd of 1.1 nM).Fórmula:C18H13ClFN3Pureza:98.35%Cor e Forma:SolidPeso molecular:325.77Ref: TM-T12717
1mg78,00€5mg169,00€10mg246,00€25mg406,00€50mg562,00€100mg702,00€200mg949,00€1mL*10mM (DMSO)178,00€
