Receptor Sigma
Os receptores sigma são sítios de ligação únicos que, ao contrário dos GPCRs tradicionais, não se enquadram nas categorias clássicas de proteínas receptoras. Eles estão envolvidos na modulação dos sistemas de neurotransmissores e têm sido implicados em vários distúrbios neurológicos e psiquiátricos. Os receptores sigma também estão associados à sobrevivência celular, e seus ligantes estão sendo explorados para aplicações terapêuticas em neuroproteção, câncer e manejo da dor. Na CymitQuimica, oferecemos uma seleção de moduladores de receptores sigma de alta qualidade para apoiar sua pesquisa em neurociência, oncologia e biologia de receptores.
Produtos da "Receptor Sigma"
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Blarcamesine
CAS:Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.Fórmula:C19H23NOPureza:99.87%Cor e Forma:SolidPeso molecular:281.39BD-1047
CAS:BD-1047 is a selective functional antagonist of sigma receptors. It can alleviate climbing behavior induced by Apomorphine and head twitching caused by Phencyclidine.Fórmula:C13H20Cl2N2Cor e Forma:SolidPeso molecular:275.217Amitriptyline
CAS:Amitriptyline: a tricyclic antidepressant used for depression and neuropathic pain.Fórmula:C20H23NPureza:98.24% - 99.64%Cor e Forma:Crystals SolidPeso molecular:277.4Opipramol
CAS:Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.Fórmula:C23H29N3OPureza:99.84% - 99.98%Cor e Forma:SolidPeso molecular:363.5Sigma-1 receptor antagonist 3
CAS:Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Fórmula:C19H23ClFN3OPureza:100%Cor e Forma:SolidPeso molecular:363.86Pre-084
CAS:Pre-084 is a high affinity, selective σ1 agonist.Fórmula:C19H28ClNO3Pureza:99.91%Cor e Forma:SolidPeso molecular:353.88Sigma-LIGAND-1
CAS:Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.Fórmula:C27H33NO4Pureza:100%Cor e Forma:SolidPeso molecular:435.56Ref: TM-T13510
1mg64,00€5mg149,00€10mg215,00€25mg335,00€50mg452,00€100mg620,00€200mg835,00€1mL*10mM (DMSO)172,00€KB-5492 free base
CAS:KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.Fórmula:C23H30N2O6Pureza:97.72% - 99.07%Cor e Forma:SolidPeso molecular:430.49Ref: TM-T62396
2mg42,00€5mg62,00€10mg87,00€25mg126,00€50mg177,00€100mg263,00€500mg647,00€1mL*10mM (DMSO)67,00€SARS-CoV-2-IN-57
CAS:SARS-CoV-2-IN-57 (compound (+)-R-26) is a potent inhibitor of SARS-CoV-2 with an IC50 of 80 nM and demonstrates high affinity for the Sigma Receptor, exhibitingFórmula:C23H37N3OPureza:98%Cor e Forma:SolidPeso molecular:371.56UKH-1114
CAS:UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.Fórmula:C22H24F3NOCor e Forma:SolidPeso molecular:375.43AB21 oxalate
AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.Fórmula:C25H30N2O5Pureza:98%Cor e Forma:SolidPeso molecular:438.52BD1063 dhydrochloride
CAS:BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).Fórmula:C13H20Cl4N2Pureza:99.52% - ≥95%Cor e Forma:SolidPeso molecular:346.12Ref: TM-T7488
2mg48,00€5mg72,00€10mg90,00€25mg187,00€50mg339,00€100mg499,00€200mg702,00€500mg1.074,00€Sigma-1 receptor antagonist 4
Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-inducedFórmula:C22H26N2OCor e Forma:SolidPeso molecular:334.45KB-5492 FA
KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8Fórmula:C24H32N2O8Pureza:98.54%Cor e Forma:SolidPeso molecular:476.52PD 144418
CAS:PD 144418 displays potential antipsychotic activity.Fórmula:C18H22N2OPureza:98%Cor e Forma:SolidPeso molecular:282.38Sigma-1 receptor antagonist 1
CAS:Sigma-1 receptor antagonist 1 is an effective and selective antagonist of sigma-1 receptor.Fórmula:C19H23Cl2N3OPureza:99.81%Cor e Forma:SolidPeso molecular:380.31S1RA
CAS:S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2Fórmula:C20H23N3O2Pureza:99.45%Cor e Forma:SolidPeso molecular:337.42BMY-14802 hydrochloride
CAS:BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects.Fórmula:C18H23ClF2N4OPureza:98.64%Cor e Forma:SolidPeso molecular:384.85Sigma-1 receptor antagonist 2
CAS:Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).Fórmula:C20H26ClN3O2Pureza:99.52%Cor e Forma:SolidPeso molecular:375.89Ref: TM-T12911
1mg64,00€5mg145,00€10mg235,00€25mg394,00€50mg562,00€100mg758,00€200mg1.017,00€1mL*10mM (DMSO)160,00€Ditolylguanidine
CAS:Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).Fórmula:C15H17N3Pureza:98.42%Cor e Forma:White To Pinkish Solid PowderPeso molecular:239.32
