Receptor de Canabinóides
Os receptores de canabinoides são GPCRs que mediam os efeitos dos canabinoides endógenos (endocanabinoides) e dos fitocanabinoides, como aqueles encontrados na cannabis. Os dois principais tipos de receptores de canabinoides, CB1 e CB2, estão envolvidos na regulação de uma ampla gama de processos fisiológicos, incluindo percepção da dor, apetite, humor e função imunológica. Moduladores de receptores de canabinoides têm potencial terapêutico no tratamento de condições como dor crônica, epilepsia e esclerose múltipla. Na CymitQuimica, oferecemos uma ampla gama de moduladores de receptores de canabinoides de alta qualidade para apoiar sua pesquisa em neurofarmacologia, manejo da dor e imunologia.
Produtos da "Receptor de Canabinóides"
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Taranabant racemate
CAS:Taranabant racemate is an antagonist and/or inverse agonist of the Cannabinoid-1 (CB1) receptor.Fórmula:C27H25ClF3N3O2Pureza:98%Cor e Forma:SolidPeso molecular:515.95AM404
CAS:AM404 is a cannabinoid reuptake inhibitor and a TRPV (1) activator with neuroprotective and anticancer activities that blocks anandamide transport.Fórmula:C26H37NO2Cor e Forma:SolidPeso molecular:395.58Δ8-THC methyl ether
CAS:Δ8-THC methyl ether (compound 3) demonstrates a strong docking score of -10.167 kcal/mol for the CB2 receptor. Additionally, Δ8-THC methyl ether exhibits antinociceptive activity in mice.Fórmula:C22H32O2Cor e Forma:SolidPeso molecular:328.49AEF0117
CAS:AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.Fórmula:C29H40O3Pureza:99.58%Cor e Forma:SolidPeso molecular:436.63AZD1940
CAS:AZD1940 (UNII-0J0035E9FT) is a high affinity CB(1)/CB(2) receptor agonist of the cannabinoid with oral activity. Application in the study of orofacial pain.Fórmula:C20H29F2N3O2SPureza:99.43%Cor e Forma:SolidPeso molecular:413.52Ref: TM-T30252
1mg130,00€5mg311,00€10mg535,00€25mg847,00€50mg1.169,00€100mg1.586,00€1mL*10mM (DMSO)344,00€SR144528
CAS:SR144528 is an antagonist of the CB2 receptor (Ki = 0.6 nM) and inhibits microsomal ACAT activity (IC50 = 3.6 μM).Fórmula:C29H34ClN3OPureza:99.6%Cor e Forma:SolidPeso molecular:476.05CID 16020046
CAS:CID 16020046 (C390-0219) is a selective GPR55 antagonist, inhibiting GPR55 constitutive activity with IC50 of 0.15 μM in yeast.Fórmula:C25H19N3O4Pureza:99.03%Cor e Forma:SolidPeso molecular:425.446-Iodopravadoline
CAS:6-Iodopravadoline (AM630) is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.Fórmula:C23H25IN2O3Pureza:99.29%Cor e Forma:Off-White SolidPeso molecular:504.36Ref: TM-T14204
1mg40,00€2mg50,00€5mg73,00€10mg96,00€25mg210,00€50mg344,00€100mg550,00€1mL*10mM (DMSO)104,00€JD-5037
CAS:JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.Fórmula:C27H27Cl2N5O3SPureza:98.14% - 98.87%Cor e Forma:SolidPeso molecular:572.51Ref: TM-T4453
1mg44,00€2mg58,00€5mg95,00€10mg140,00€25mg246,00€50mg369,00€100mg550,00€1mL*10mM (DMSO)106,00€Tedalinab
CAS:Tedalinab is an effective and selective cannabinoid receptor 2 agonist.Fórmula:C19H21F2N3OPureza:98%Cor e Forma:SolidPeso molecular:345.39GP 1a
CAS:GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.Fórmula:C23H22Cl2N4OPureza:99.44%Cor e Forma:SolidPeso molecular:441.35COR659
CAS:COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.Fórmula:C16H16ClNO3SPureza:99.56%Cor e Forma:SolidPeso molecular:337.82Ref: TM-T36520
1mg52,00€2mg75,00€5mg116,00€10mg178,00€25mg324,00€50mg452,00€100mg620,00€200mg843,00€1mL*10mM (DMSO)128,00€JTE-907
CAS:JTE-907 是一种具有高度选择性和口服活性的 CB2 受体反向激动剂。JTE-907在体内展现出抗炎活性。Fórmula:C24H26N2O6Pureza:100%Cor e Forma:SolidPeso molecular:438.47Ref: TM-T19705
1mg56,00€5mg126,00€10mg187,00€25mg329,00€50mg490,00€100mg700,00€1mL*10mM (DMSO)150,00€2-Arachidonoylglycerol
CAS:In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligandFórmula:C23H38O4Pureza:95%Cor e Forma:LiquidPeso molecular:378.55CB2 PET Radioligand 1
CB2 PET Radioligand 1 (compound [18F]9) is a positron emission tomography (PET) radioligand with high affinity for the human cannabinoid receptor 2 (hCB2, Ki=7.Fórmula:C20H19F3N4OPureza:98%Cor e Forma:SolidPeso molecular:388.39Rimonabant hydrochloride
CAS:Rimonabant hydrochloride (SR 141716A) 是中心大麻素受体 1 的高效选择性反向激动剂, Ki 值为1.8 nM。它也能够抑制分枝杆菌膜蛋白3。Fórmula:C22H22Cl4N4OPureza:100% - 99.5%Cor e Forma:Off-White To White Crystalline PowderPeso molecular:500.25CB1 antagonist 4
CAS:TM38837 is an antagonist of cannabinoid receptor type 1 (CB1), with potential for the treatment of obesity and type 2 diabetes.Fórmula:C30H25Cl2F3N4OSPureza:100%Cor e Forma:SolidPeso molecular:617.51
