Açúcares e Nucleobases da Espinha Dorsal

5-Ethyluracil is a nucleobase that is structurally similar to thymine. It inhibits the replication of human mitochondrial DNA and herpes simplex virus type-1 (HSV-1) by binding with the viral nucleic acid. 5-Ethyluracil has been shown to be an effective antiviral agent in clinical trials, where it was found to inhibit the replication of HSV-1 in both HIV-positive and HIV-negative patients. 5-Ethyluracil has also been shown to have an inhibitory effect on mammalian cells and has been used for treatment of certain types of cancer. This drug's low energy makes it useful as a topical analgesic. The glycosidic bond makes this drug water soluble, which allows for its use as an antiseptic or disinfectant. 5-Ethyluracil is metabolized by hydrochloric acid, which produces urate, ammonia, and carbon dioxide. This drug can be

(R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil is a prodrug of 5-FU, which is a chemotherapeutic drug used to treat colorectal adenocarcinoma. It is converted in the body to 5-FU by esterases and glucuronidases, which inhibits DNA synthesis and cell division. (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil has been shown to have anticancer activity in treatment trials with multivariate logistic regression analysis and enzyme activities. The conversion of (R1)-(Tetrahydrofuran-2-yl)-5-fluorouracil into 5-FU can be inhibited by using P450 inhibitors such as ketoconazole and erythromycin, suggesting that this pharmacological agent may not be suitable for patients with liver or renal impairment.

Applications 4-(4-Fluorophenyl)-5-hydroxymethyl-6-isopropyl-2-methylthiopyrimidine (cas# 895129-11-0) is a compound useful in organic synthesis.

Autoinduction Medium (AIM) Solution for protein expression that needs little user intervention after inoculation of the culture. The principle of AIM media is based on carbon sources in the medium that are metabolized differentially to promote high density cell growth and automatically induce protein expression from lac promoters. This solution constitutes a unique combination of carbon source concentrations. AIM with pH 7.2 provides an efficient way to produce recombinant proteins for functional characterizations. This solution is useful in the study of intensity of induction, expression at different cell densities, or investigation of induction in early-, mid-, or late-log conditions of proteins of focused interest.

3-Methyluracil is a molecule with the molecular formula CH3CHO. It has a protonated form, which is NH2CH2COOH, and an unprotonated form, which is NHCH2COOH. The protonation of 3-methyluracil can be seen in the hydrogen bonding between the two molecules. 3-Methyluracil is found in clinical studies as an effective treatment for obesity. It also has been shown to have nucleobase sequence specificity and can be used to detect adenosine in RNA sequences. 3-Methyluracil is a nucleophilic base that can bond with hydroxide ions from water or other protic solvents. This reaction results in the molecule becoming more acidic, which can be seen by the decrease in pH level when it comes into contact with hydrochloric acid.

3,6-Dichlorotrimellitic anhydride serves as the essential precursor in the synthesis of various dichlorinated fluoresceins and rhodamines.

6-Propyl-2-thiouracil is a form of thiouracil that can be used in the diagnosis and treatment of infectious diseases. 6-Propyl-2-thiouracil binds to DNA polymerase and inhibits its activity, which prevents the replication of viruses. It has been shown to inhibit cell growth in a model system for human erythrocytes. This drug also inhibits the production of basic proteins by binding to the basic protein promoter region. 6-Propyl-2-thiouracil is metabolized by propylthiouracil reductase, which converts it into an inactive form. The intracellular targets are cell nuclei and cell cytoplasmic organelles such as mitochondria and lysosomes. This drug is effective against a number of viral infections, including HIV, hepatitis C, herpes simplex type 2, cytomegalovirus, Epstein Barr virus (EBV), influenza A virus H

1-Ethoxymethyl-5-fluorouracil (EMFU) is an oral anti-cancer drug that has potent antitumor activity. EMFU is metabolized by the liver to 5-FU, which is then distributed throughout the body and binds to DNA through hydrogen bonding interactions. This binding inhibits DNA synthesis and leads to cell death. EMFU has been shown to be active against a variety of tumors in animal models, including human liver cancer cells. EMFU is also being investigated for its potential use as an adjuvant therapy for patients with breast cancer receiving radiation therapy or chemotherapy. Clinical studies have shown that EMFU can significantly reduce tumor progression and disease activity in these patients.

Applications A DNA adduct ethylene oxide hydroxyethylnitrosourea. It is also used in the preparation of acyclic nucleosides and nucleotides as antiviral agents. References Snoeck, R., et al.: Antimicrob. Agents Chemother., 32, 1839 (1988), Bronson, J., et al.: J .Med. Chem., 32, 1457 (1989), Balzarini, J., et al.: J. Biol. Chem., 266, 8686 (1991),

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