Açúcares e Nucleobases da Espinha Dorsal

N-4-Benzoyl-5-fluorocytosine is a potent antiviral drug that inhibits HIV in human cells. It is synthesized by the reaction of 6-chloropurine and benzoyl chloride. N-4-Benzoyl-5-fluorocytosine has been shown to be cytotoxic towards human cells, with significant cytotoxicity observed at concentrations higher than 100 μM. This agent also inhibits DNA synthesis in human blood mononuclear cells, which may be due to its ability to inhibit the metabolism of adenine and 5-fluorocytosine into uracil, thus preventing the incorporation of these nucleotide bases into DNA.

Fluorescent 7-Hydroxy-4-methylquinolone detects DNA hydroxyl radicals; store in dark.

5-(2-Trifluoroacetylaminohexafluoroprop-2-Yl)-2'-Deoxyuridine is a modified form of uridine that is synthesized by reacting trifluoroacetyl chloride with 2'-deoxyuridine. 5-(2-Trifluoroacetylaminohexafluoroprop-2-Yl)-2'-Deoxyuridine has been shown to inhibit the replication of viruses such as human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). 5-(2-Trifluoroacetylaminohexafluoroprop-2-Yl)-2'-Deoxyuridine also inhibits the synthesis of RNA in cells and has been shown to be effective against bacteria such as Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. The anti-viral activity of 5

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1,8-Diazafluoren-9-one (DFO) is used to find fingerprints on porous surfaces.

Uracil-4-acetic acid is a monocarboxylic acid that is synthesized in mammalian cells. It can also be obtained by hydrolysis of orotic acid, which was previously synthesized from uridine and phosphorolysis of sephadex g-100. Uracil-4-acetic acid is used to produce uridine through the action of an enzyme called uridine phosphorylase. This enzyme catalyzes the reaction between ATP and uracil, as well as the conversion of orotic acid to orotidine 5′-monophosphate decarboxylase. Uracil-4-acetic acid has been shown to inhibit the growth of toxoplasma, but it has not been determined whether this inhibition is due to its role in the synthesis of uridine or its toxic effects on the parasite.

N9-Benzyladenine is a drug that regulates the activity of adenosine receptors. It is an endogenous substance found in plants and animals, but can also be synthesized chemically. N9-Benzyladenine has been shown to inhibit protein synthesis by binding to cyclic nucleotide phosphodiesterases, resulting in the accumulation of cyclic AMP and activation of adenylate cyclase. This leads to an increase in intracellular cAMP levels that is mediated by Gs protein coupled receptors. N9-Benzyladenine has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit the release of tumor necrosis factor-α (TNF-α).

Cy7 cadaverine is commonly used in biomolecular labeling, fluorescence imaging and other fluorescence biological analysis.