Cell Cycle/Checkpoint
Cell cycle/checkpoint inhibitors are compounds that disrupt the normal progression of the cell cycle, particularly at key regulatory checkpoints. These inhibitors are crucial for studying cell division, understanding cancer cell proliferation, and developing anti-cancer therapies. By targeting specific phases of the cell cycle, these inhibitors can induce cell cycle arrest, leading to apoptosis or senescence in rapidly dividing cells. At CymitQuimica, we offer a diverse range of high-quality cell cycle/checkpoint inhibitors to support your research in cancer biology, cell biology, and drug development.
Subcategories of "Cell Cycle/Checkpoint"
- Aurora Kinase
- CDK
- Cell Cycle Arrest
- Chk
- c-Myc
- Dynamin
- DYRK
- Ferroptosis
- HSP
- Integrin
- Kinesin
- KSP
- LIM Kinase
- Microtubule Associated
- PKC
- PLK
- Rho
- ROCK
- Wee1
Show 11 more subcategories
Products of "Cell Cycle/Checkpoint"
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Cilengitide
CAS:Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.Formula:C27H40N8O7Purity:98% - 99.8%Color and Shape:SolidMolecular weight:588.66Ref: TM-T2494
1mg49.00€2mg70.00€5mg96.00€10mg160.00€25mg274.00€50mg439.00€100mg632.00€1mL*10mM (DMSO)137.00€Mirvetuximab
CAS:Mirvetuximab, a monoclonal antibody targeting FOLR1/FRα, treats ovarian and FRα-positive cancers, often paired with platinum-based drugs.Purity:> 95% - > 95%Color and Shape:LiquidMolecular weight:148 kDa (average)Ispinesib
CAS:Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplasticFormula:C30H33ClN4O2Purity:98% - 98.59%Color and Shape:SolidMolecular weight:517.06Ref: TM-T2103
1mg39.00€2mg50.00€5mg79.00€10mg118.00€25mg210.00€50mg339.00€100mg557.00€500mg1,216.00€1mL*10mM (DMSO)89.00€CDK8/19-IN-1
CAS:CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).Formula:C19H18N4O4S2Purity:98%Color and Shape:SolidMolecular weight:430.5Werner syndrome RecQ helicase-IN-1
CAS:Werner syndrome RecQ helicase-IN-1 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomachFormula:C31H31ClF3N9O5Purity:98.74% - 99.62%Color and Shape:SolidMolecular weight:702.08Ref: TM-T72107
1mg60.00€5mg125.00€10mg177.00€25mg296.00€50mg502.00€100mg803.00€500mg1,795.00€1mL*10mM (DMSO)822.00€CDK12-IN-E9
CAS:CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux.Formula:C24H30N6O2Color and Shape:SolidMolecular weight:434.53Folinic Acid Calcium Salt Pentahydrate
CAS:Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.Formula:C20H21CaN7O7·5H2OPurity:100% - 99.17%Color and Shape:Yellowish-White To Yellow PowderMolecular weight:601.58NITD-2
CAS:NITD-2 is a DENV RdRp inhibitor with poor cell membrane penetration; no vaccine or antiviral for DENV exists.Formula:C23H19N3O4SPurity:98.03% - 99.46%Color and Shape:SolidMolecular weight:433.48Ref: TM-T8886
1mg74.00€5mg170.00€10mg274.00€25mg472.00€50mg655.00€100mg944.00€200mg1,264.00€1mL*10mM (DMSO)188.00€GP-82996
CAS:GP-82996 (CINK4) inhibits CDK4/6; IC50s: 1.5 μM (CDK4/D1), 5.6 μM (CDK6/D1), 25 μM (Cdk5/p35); triggers U2OS cancer cell apoptosis.Formula:C27H32N6OPurity:99.57%Color and Shape:SolidMolecular weight:456.58N6,N6-Dimethyladenosine
CAS:N6,N6-Dimethyladenosine is find in mycobacterium bovis Bacille Calmette-Guérin tRNA.Formula:C12H17N5O4Purity:98.79%Color and Shape:White PowderMolecular weight:295.29Aurora kinase inhibitor-3
CAS:Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK,Formula:C21H18F3N5OPurity:98.91%Color and Shape:SolidMolecular weight:413.4Ref: TM-T5524
1mg78.00€2mg97.00€5mg188.00€10mg298.00€25mg500.00€50mg710.00€100mg938.00€200mg1,311.00€1mL*10mM (DMSO)215.00€HDAC-IN-85
HDAC-IN-85 (Compound 1) is an HDAC inhibitor capable of crossing the blood-brain barrier. It exhibits inhibitory effects on brain tumor cell lines and can induce acetylation, resulting in DNA double-strand breaks and promoting RAD51 ubiquitination, which disrupts the DNA repair process. HDAC-IN-85 is applicable in studies of glioblastoma.Formula:C24H27FN4O5Color and Shape:SolidMolecular weight:470.49RG7800
CAS:RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier.Formula:C24H28N6OPurity:99.44%Color and Shape:SolidMolecular weight:416.52ART558
CAS:ART558 is a potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM).Formula:C21H21F3N4O2Purity:99.18%Color and Shape:SolidMolecular weight:418.41PD-1/PD-L1-IN-NP19
CAS:PD-1/PD-L1-IN-NP19: a PD-1/PD-L1 inhibitor with 12.5 nM IC50, may boost antitumor immunity.Formula:C33H31ClN2O4Purity:98%Color and Shape:SolidMolecular weight:555.06Doxifluridine
CAS:Doxifluridine (AMC 0101) is a fluoropyrimidine derivative and oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity.Formula:C9H11FN2O5Purity:99.47% - 99.86%Color and Shape:White SolidMolecular weight:246.192′-Deoxy-2′-fluoroguanosine
CAS:2′-Deoxy-2′-fluoroguanosine is a nucleoside analog that potently inhibits influenza virus A and B strains(EC90 <0.35 μM).Formula:C10H12FN5O4Purity:99.82%Color and Shape:SolidMolecular weight:285.23Raltitrexed
CAS:Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.Formula:C21H22N4O6SPurity:98.99% - 99.06%Color and Shape:Yellow Crystalline PowderMolecular weight:458.49SCH-1473759
CAS:SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).Formula:C20H26N8OSPurity:98%Color and Shape:SolidMolecular weight:426.54Cucurbitacin B
CAS:Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells.Formula:C32H46O8Purity:97.10% - 99.33%Color and Shape:SolidMolecular weight:558.7
