Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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JAK1-IN-16
JAK1-IN-16 (compound 4l) acts as an inhibitor of JAK1/STAT3 and effectively downregulates the expression of TLR4 protein.Formula:C20H15ClF3N3OSColor and Shape:SolidMolecular weight:437.87Tyk2-IN-22
CAS:Tyk2-IN-22 (Compound A8) is a selective inhibitor of tyrosine kinase 2 (Tyk2), effectively inhibiting Tyk2, JAK1, and JAK3 with IC50 values of 9.7 nM, 148.6 nM, and 883.3 nM, respectively. Additionally, Tyk2-IN-22 suppresses downstream STAT5 phosphorylation.Formula:C16H16ClN5O2Color and Shape:SolidMolecular weight:345.78JAK-STAT-IN-1
CAS:JAK-STAT-IN-1 is a specific JAK-STAT inhibitor indicated for the study of autoimmune diseases.Formula:C21H21N5O2Purity:99.21%Color and Shape:SolidMolecular weight:375.42PROTAC BRD4 Degrader-27
CAS:PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.Formula:C37H30F2N6O7Color and Shape:SolidMolecular weight:708.67Bromodomain inhibitor-13
CAS:Bromodomain Inhibitor-13 (Compound 1), an analog of PFI-3, is a bromodomain-containing protein (BCP) inhibitor. It specifically targets the bromodomains of SMARCA2, SMARCA4, and the first and second bromodomains of PB1 [PB1(5) and PB1(2)], with dissociation constants (KD) of 37, 53, 30, and 190 nM, respectively.Formula:C21H22N4O2Color and Shape:SolidMolecular weight:362.43Antitumor agent-104
CAS:Antitumor Agent-104 (Compound 9) serves as an antineoplastic by impeding DNA repair mechanisms in tumor cells, primarily through the inhibition of PARP1 enzymeFormula:C31H33FN6O3Purity:98%Color and Shape:SolidMolecular weight:556.633,6-Dihydroxyflavone
CAS:3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.Formula:C15H10O4Purity:99.92%Color and Shape:SolidMolecular weight:254.24Dehydrocorydaline chloride
CAS:Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid with anti-inflammatory and anti-cancer activity. Can improve the activation of p38 MAPK.Formula:C22H24ClNO4Purity:99.53%Color and Shape:SolidMolecular weight:401.88Ref: TM-T10990
1mg58.00€5mg111.00€10mg160.00€25mg264.00€50mg396.00€100mg563.00€1mL*10mM (DMSO)124.00€OG-L002
CAS:OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.Formula:C15H15NOPurity:97.05%Color and Shape:SolidMolecular weight:225.29Ref: TM-T6073
1mg42.00€5mg88.00€10mg137.00€25mg253.00€50mg416.00€100mg602.00€500mg1,254.00€1mL*10mM (DMSO)52.00€Diflunisal
CAS:Diflunisal (Dolobid) is a cyclooxygenase (COX) Inhibitor, used as an anti-inflammatory analgesic.Formula:C13H8F2O3Purity:98.92% - 99.42%Color and Shape:SolidMolecular weight:250.2ORIC-944 TFA
ORIC-944 TFA is an orally bioavailable selective polycomb repressive complex 2 (PRC2) inhibitor with antitumor activity.Formula:C28H26F4N6O3Color and Shape:SoildMolecular weight:570.54EPZ032597
CAS:EPZ032597 is a novel selective inhibitor of SMYD2 with an IC50 of 16 nM. EPZ032597 has anticancer activity and prevent and treat pancreatic cancerFormula:C20H23N7OPurity:99.41%Color and Shape:SolidMolecular weight:377.441,4-DPCA
CAS:1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibitingFormula:C13H8N2O3Purity:97.75%Color and Shape:SolidMolecular weight:240.21Ref: TM-T21653
5mg51.00€10mg84.00€25mg153.00€50mg235.00€100mg376.00€200mg553.00€500mg883.00€1mL*10mM (DMSO)57.00€SGC-SMARCA-BRDVIII
CAS:SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM,Formula:C19H25N5O3Purity:99.6% - 99.85%Color and Shape:SolidMolecular weight:371.43Ref: TM-T9568
1mg47.00€5mg70.00€10mg106.00€25mg235.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)57.00€LSD1/HDAC-IN-1
CAS:LSD1/HDAC-IN-1 (compound 2) serves as an effective inhibitor of both HDAC and LSD1, demonstrating IC50 values of 0.125 nM, 0.373 nM, 0.0118 nM, 0.103 nM, and 0.571 μM for HDAC1, HDAC2, HDAC6, HDAC8, and LSD1 respectively. This compound plays a crucial role in cancer research.Formula:C18H18N2O4SColor and Shape:SolidMolecular weight:358.41Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formula:C16H12O5Purity:98.72% - 99.55%Color and Shape:SolidMolecular weight:284.26PT2399
CAS:PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Formula:C17H10F5NO4SPurity:98.8% - 99.07%Color and Shape:SolidMolecular weight:419.32Ref: TM-T12675L
1mg99.00€5mg235.00€10mg354.00€25mg640.00€50mg944.00€100mg1,320.00€1mL*10mM (DMSO)259.00€JAK/HDAC-IN-4
JAK/HDAC-IN-4 (compound 11 i) is a dual inhibitor targeting both JAK2 and HDAC6, with IC50 values of 0.49 nM and 12 nM respectively. It inhibits cell proliferation and the production of nitric oxide. In a mouse model induced by Imiquimod, JAK/HDAC-IN-4 ameliorates psoriasiform skin lesions with low toxicity.Formula:C30H32N8O5SColor and Shape:SolidMolecular weight:616.69MS645
CAS:MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.Formula:C48H54Cl2N10O2S2Purity:98%Color and Shape:SolidMolecular weight:938.04WM-1119
CAS:WM-1119 is a highly potent, selective KAT6A/B inhibitorFormula:C18H13F2N3O3SPurity:96.59% - 98.18%Color and Shape:SolidMolecular weight:389.38
