Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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VTP50469
CAS:VTP50469 is a highly selective and orally active small molecule inhibitor of the Menin-MLL protein-protein interaction.Cost-effective and quality-assured.Formula:C32H47FN6O4SPurity:98.31% - 98.92%Color and Shape:SolidMolecular weight:630.82Ref: TM-T13336
1mg167.00€5mg354.00€10mg424.00€25mg592.00€50mg755.00€100mg1,017.00€1mL*10mM (DMSO)492.00€EML734
CAS:EML734 is a potent, selective inhibitor of PRMT7 and PRMT9, demonstrating inhibitory concentration 50 (IC50) values of 315 nM for PRMT7 and 0.89 μM for PRMT9.Formula:C27H32N10O7Purity:98%Color and Shape:SolidMolecular weight:608.61AMPK activator 16
CAS:AMPK activator16 (compound 6) functions as an AMP-activated protein kinase (AMPK) inhibitor. It interacts effectively with crucial AMPK residues, significantly activating the enzyme. In N2a cells, AMPK activator16 enhances the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) and phosphorylated raptor (p-raptor).Formula:C23H20ClNO5SColor and Shape:SolidMolecular weight:457.927GSK 690 Hydrochloride
CAS:GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.Formula:C24H24ClN3OPurity:98%Color and Shape:SolidMolecular weight:405.92RO495
CAS:RO495 (CS-2667), a potent inhibitor of TYK2, inhibits TYK2 with IC50 of 1.5nM as tested in cell-based pharmacological assaysFormula:C17H14Cl2N6OPurity:97.94%Color and Shape:SolidMolecular weight:389.24Ref: TM-T22416
1mg64.00€2mg87.00€5mg117.00€10mg183.00€25mg354.00€50mg520.00€100mg702.00€200mg944.00€1mL*10mM (DMSO)140.00€E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:98.83%Color and Shape:SolidMolecular weight:378.46Ref: TM-T6823
1mg50.00€2mg72.00€5mg107.00€10mg167.00€25mg304.00€50mg500.00€100mg725.00€200mg1,017.00€500mg1,510.00€1mL*10mM (DMSO)88.00€Ivangustin
CAS:Ivangustin is derived from Inula britannica and exhibits significant cytotoxicity against human cancer cell lines.Formula:C15H20O3Purity:99.86%Color and Shape:SolidMolecular weight:248.32Ref: TM-TN4340
1mg183.00€5mg457.00€10mg652.00€25mg1,026.00€50mg1,406.00€100mg1,890.00€1mL*10mM (DMSO)465.00€MOZ-IN-3
MOZ-IN-3 (Compound 6j), a potent KAT6A (MOZ) acetyltransferase inhibitor with an IC50 of 30 nM, exhibits antitumor activity against multiple myeloid leukemiaFormula:C17H13FN2O3SPurity:98%Color and Shape:SolidMolecular weight:344.36Menin-MLL inhibitor 34
Menin-MLL inhibitor 34 (Compound 37) is a selective and potent inhibitor of Menin-MLL, exhibiting an IC50 of 18.21 nM against Menin. This compound effectively reduces Menin protein levels and downregulates MEN1 transcription, demonstrating sustained anti-leukemia effects.Formula:C40H54FN9O4SColor and Shape:SolidMolecular weight:775.98MicroRNA-21-IN-2
CAS:MicroRNA-21-IN-2 is a potential miR-21 inhibitor with an AC50 value of 3.29 μM. MicroRNA-21-IN-2 can be used to study cancer.Formula:C17H15N3O3SPurity:99.2%Color and Shape:SolidMolecular weight:341.38DCLX069
CAS:DCLX069: PRMT1 inhibitor, IC50=17.9µM, targets SAM pocket, inhibits breast/liver cancer, and AML cell growth.Formula:C20H25N3O2Purity:97.76%Color and Shape:SolidMolecular weight:339.43Ref: TM-T27133
1mg38.00€2mg49.00€5mg79.00€10mg111.00€25mg187.00€50mg305.00€100mg487.00€500mg1,035.00€1mL*10mM (DMSO)92.00€KDM5A-IN-1
CAS:KDM5A-IN-1 is a pan-histidine lysine demethylase 5 KDM5 inhibitor that inhibits KDM5A, KDM5B, and KDM5C.Can be used in the study of cancer.Formula:C15H22N4O2Purity:99.8%Color and Shape:SolidMolecular weight:290.36JAK-IN-5 hydrochloride
CAS:JAK-IN-5 hydrochloride is a JAK inhibitor [1].Formula:C27H32ClFN6OColor and Shape:SolidMolecular weight:511.03Palmatine chloride
CAS:Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.Formula:C21H22ClNO4Purity:97.9% - 99.47%Color and Shape:SolidMolecular weight:387.8573-deazaneplanocin A HCl
CAS:3-deazaneplanocin A HCl is both an S-adenosyl-l-homocysteine hydrolase inhibitor and an enhancer of zeste homolog 2(EZH2) inhibitor.Formula:C12H15ClN4O3Purity:93.24% - 98.34%Color and Shape:SolidMolecular weight:298.73Cenacitinib
CAS:Cenacitinib is an effective inhibitor of Janus kinase (Janus kinase) and possesses anti-inflammatory activity.Formula:C19H19F2N7O3Color and Shape:SolidMolecular weight:431.40SGI-1776
CAS:SGI-1776 (Pim-Kinase Inhibitor IX) has been used in trials studying the treatment of Prostate Cancer, Non-Hodgkins Lymphoma, and Relapsed/Refractory Leukemias.Formula:C20H22F3N5OPurity:100% - 99.84%Color and Shape:SolidMolecular weight:405.42WDR5-0102
CAS:WDR5-0102 inhibits WDR5-MLL1 (Kd=4 μM), blocks MLL1 HMT activity, but doesn't affect SETD7 and 6 other HMTs.Formula:C18H19ClN4O3Purity:97.16%Color and Shape:SolidMolecular weight:374.82Ref: TM-T67947
1mg77.00€5mg169.00€10mg274.00€25mg550.00€50mg792.00€100mg1,093.00€500mg2,175.00€1mL*10mM (DMSO)215.00€Nimucitinib
CAS:Nimucitinib is a Janus kinase (JAK) inhibitor that can be used to treat dry eye and promote tear production.Formula:C25H26F2N6O2Purity:98.71%Color and Shape:SoildMolecular weight:480.51Ref: TM-T67907
1mg96.00€2mg139.00€5mg227.00€10mg354.00€25mg653.00€50mg938.00€100mg1,454.00€500mg2,822.00€HDACs/EZH2-IN-1
HDACs/EZH2-IN-1 (Compound 22a) is a dual inhibitor of HDACs and EZH2, exhibiting potent inhibitory activity, with EZH2 Y641N being suppressed by 98% at 50 nM. It selectively targets HDAC1 and HDAC6, with IC50 values of 0.23 μM and 0.07 μM, respectively. HDACs/EZH2-IN-1 effectively inhibits the proliferation of diffuse large B-cell lymphoma cells harboring EZH2 mutations and various acute myeloid leukemia cells. Additionally, this compound has the capability to induce cellular differentiation and apoptosis (Apoptosis).Formula:C29H36BrN7O4Color and Shape:SolidMolecular weight:626.54
