Chromatin/Epigenetics

Igermetostat, an EZH2 inhibitor, is utilized both in vivo and in vitro for cancer research [1].

G244-LM is a potent and specific inhibitor of tankyrase 1/2. G244-LM inhibits Wnt signaling.

Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties.

PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 of

Cycloastragenol, a saponin from Astragalus, could be a new depression treatment.

I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.

JAK-IN-34 (compound 11n) is a potent inhibitor of Janus kinases (JAKs), demonstrating IC50 values of 0.40 nM for JAK1, 0.83 nM for JAK2, 2.10 nM for JAK3,

PARP10-IN-3: selective inhibitor for mono-ADP-ribotransferase PARP10 (IC50: 480nM), also affects PARP2 and PARP15 (IC50: 1.7μM).

Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.

XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).

SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.

Anti-PARP1 Antibody (6I459) is an antibody targeting PARP1. Anti-PARP1 Antibody (6I459) can be used in ELISA, IHC.

SMD-3236 is a PRAOTAC degrader targeting SMARCA2, designed using SMARCA ligand and VHL-1 ligand, and exhibits prolonged anti-tumor activity in vivo. SMARCA2 acts as a synthetic lethal target in cancer cells lacking SMARCA4, with SMD-3236 showing 2000-fold selectivity for SMARCA2 over SMARCA4, having a DC50 of less than 1 nM and a Dmax of over 95%. In the human cancer xenograft models deficient in SMARCA4, notably the H838 model, SMD-3236 effectively induces loss of SMARCA2 in tumor tissue while sparing the SMARCA4 protein, thereby inhibiting tumor growth. The compound consists of a target protein ligand (red part) SMI-1074, a PROTAC linker (black part) (trans-4-Ethynylcyclohexyl)methyl methanesulfonate, and an E3 ligase ligand (blue part) SMARCA2 ligand-14, forming the E3LigaseLigand-linker Conjugate 159.

PI3K/Akt/CREB activator 1 (AE-18) is an iNOS inhibitor that can be used to study vascular dementia and Parkinson's.

IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression

(S,R)-CFT8634 is a selective and orally active BRD9 protein degrader with potential for researching BRD9-mediated disorders, such as abnormal cellular

Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.

JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.

JQKD82 trihydrochloride, a cell-permeable and selective inhibitor of KDM5, enhances H3K4me3 levels and is utilized in multiple myeloma research.

GW779439X is an inhibitor of CDK.