Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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SIRT-IN-6
CAS:SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.Formula:C7H4ClN3OSColor and Shape:SolidMolecular weight:213.644L-2-Hydroxyglutaric acid disodium
CAS:L-2-Hydroxyglutaric acid disodium may affect epigenetics and contribute to renal cancer, inhibiting Mi-CK (Km 2.52 mM, Ki 11.13 mM).Formula:C5H6Na2O5Purity:≥98%Color and Shape:SolidMolecular weight:192.08NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Formula:C23H30N6O2Purity:98.33%Color and Shape:SolidMolecular weight:422.52Ref: TM-T16359
2mg42.00€5mg64.00€10mg97.00€25mg187.00€50mg301.00€100mg437.00€200mg612.00€1mL*10mM (DMSO)71.00€PROTAC SMARCA2 degrader-26
CAS:PROTAC SMARCA2 degrader-26 (compound 45) is an effective degrader of SMARCA2 using the PROTAC technology. It induces degradation of SMARCA2 and SMARCA4 in VCaP cells, with degradation percentages of 94% and 57%, respectively. Additionally, PROTAC SMARCA2 degrader-26 demonstrates antiproliferative activity.Formula:C46H54N8O5SColor and Shape:SolidMolecular weight:831.04KF 13218
CAS:KF 13218 is a selective, potent and long lasting thromboxane B2 (TXB2) synthase inhibitor with an IC50 value of 5.3±1.3 nM.Formula:C20H20N2O3Purity:98%Color and Shape:SolidMolecular weight:336.38MS402
CAS:MS402 is a novel BD1-selective BET BrD inhibitor.Formula:C20H19ClN2O3Purity:99.72%Color and Shape:SolidMolecular weight:370.83Ref: TM-T12112
5mg47.00€10mg65.00€25mg117.00€50mg177.00€100mg304.00€200mg437.00€1mL*10mM (DMSO)49.00€BD-9136
BD-9136, a highly selective BRD4 degrader, demonstrates the capability to inhibit tumor growth without inducing adverse effects in mice, showing potential forFormula:C44H44N10O5SPurity:98%Color and Shape:SolidMolecular weight:824.95JAK-IN-33
JAK-IN-33 (Compound 3 (R)) is a selective inhibitor of the Janus kinase (JAK) family [1].Purity:98%Color and Shape:Odour SolidDW14800
CAS:DW14800 is an inhibitor of PRMT5 (IC50 = 17 nM), enhances the transcription of HNF4α, and reduces the level of H4R3me2s.Formula:C31H36N4O3Purity:97.26% - 99.12%Color and Shape:SolidMolecular weight:512.64Ref: TM-T11131
1mg87.00€2mg130.00€5mg216.00€10mg378.00€25mg717.00€50mg948.00€100mg1,415.00€1mL*10mM (DMSO)245.00€NSC 694623
CAS:NSC 694623: Potent HAT inhibitor, IC50=15.9 μM against PCAF, anti-cancer properties.Formula:C16H16N2OSPurity:99.87%Color and Shape:SolidMolecular weight:284.38CPI-455 HCl
CAS:CPI-455: specific KDM5A inhibitor, IC50=10±1nM, increases H3K4me3, reduces DTPs in cancer cells.Formula:C16H15ClN4OPurity:98%Color and Shape:SolidMolecular weight:314.77KDM5-IN-1
CAS:KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.Formula:C17H20N6OPurity:98.08%Color and Shape:SolidMolecular weight:324.38Ref: TM-T15649
1mg64.00€5mg187.00€10mg284.00€25mg452.00€50mg645.00€100mg867.00€500mgTo inquire1mL*10mM (DMSO)137.00€GSK9311 hydrochloride
CAS:GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).Formula:C24H32ClN5O3Purity:98%Color and Shape:SolidMolecular weight:474AZ9482
CAS:AZ9482, a potent PARP inhibitor with 2-piperazinyl-3-cyano-pyridine linkage, causes centrosome declustering in HeLa cells with an EC50 < 18 nM.Formula:C26H22N6O2Purity:99.86%Color and Shape:SolidMolecular weight:450.49Ref: TM-T22264
1mg57.00€5mg131.00€10mg205.00€25mg389.00€50mg565.00€100mg822.00€1mL*10mM (DMSO)140.00€Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Formula:C27H21N3O3Purity:96.25%Color and Shape:SolidMolecular weight:435.47Ref: TM-T35570
1mg90.00€5mg187.00€10mg305.00€25mg520.00€50mg748.00€100mg1,026.00€1mL*10mM (DMSO)215.00€RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Formula:C29H35N7O4Purity:97.29% - 99.91%Color and Shape:SolidMolecular weight:545.63Peficitinib
CAS:Peficitinib (ASP015K) (ASP015K, JNJ-54781532) is an orally bioavailable JAK inhibitor. Phase 3.Formula:C18H22N4O2Purity:98.67% - 99.4%Color and Shape:SolidMolecular weight:326.39Ref: TM-T6933
2mg40.00€5mg66.00€10mg104.00€25mg182.00€50mg283.00€100mg439.00€200mg645.00€1mL*10mM (DMSO)73.00€Aurora kinase inhibitor-2
CAS:Aurora kinase inhibitor-2 (IUN-70219) is a cell-permeable anilinoquinazoline that inhibit the activity of Aurora A (IC50 = 0.39 M).Formula:C23H20N4O3Purity:98.66%Color and Shape:SolidMolecular weight:400.43Ref: TM-T9040
1mg66.00€5mg145.00€10mg212.00€25mg380.00€50mg562.00€100mg832.00€200mg1,121.00€1mL*10mM (DMSO)167.00€FLLL32
CAS:FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).Formula:C28H32O6Purity:96.39% - 97.90%Color and Shape:SolidMolecular weight:464.55Ref: TM-T6838
2mg46.00€5mg66.00€10mg93.00€25mg124.00€50mg197.00€100mg350.00€500mg840.00€1mL*10mM (DMSO)72.00€Tazemetostat
CAS:Tazemetostat (EPZ6438): Oral EZH2 inhibitor, blocks histone H3K27 methylation, potential cancer therapy.Formula:C34H44N4O4Purity:98.24% - ≥95%Color and Shape:SolidMolecular weight:572.74Ref: TM-T1788
2mg38.00€5mg55.00€10mg78.00€25mg96.00€50mg97.00€100mg160.00€500mg404.00€1mL*10mM (DMSO)70.00€
