Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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DDP-38003 dihydrochloride
CAS:DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).Formula:C21H28Cl2N4OPurity:99.5%Color and Shape:SolidMolecular weight:423.38(Z)-SMI-4a
CAS:(Z)-SMI-4a (TCS PIM-1 4a) is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.Formula:C11H6F3NO2SPurity:97.66% - 99.44%Color and Shape:SolidMolecular weight:273.232,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.Formula:C16H13Cl2N3O2Purity:98.77%Color and Shape:SolidMolecular weight:350.2Anti-PARP Antibody (1W26)
Anti-PARP Antibody (1W26) is a Mouse antibody targeting PARP. Anti-PARP Antibody (1W26) can be used in WB,IHC-P,IP.Color and Shape:Odour Liquid6-Bromo-3-methyl-1,4-dihydroquinazolin-2-one
CAS:CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).Formula:C9H9BrN2OPurity:99.28%Color and Shape:SolidMolecular weight:241.08Ref: TM-T8609
1mg88.00€5mg170.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)162.00€JAK-IN-14
CAS:JAK-IN-14 (compound 16) is a specific JAK1 inhibitor. It prevents JAK1 phosphorylation by binding to the active site of JAK in immune, inflammation and cancer.Formula:C19H15FN4OPurity:98.27%Color and Shape:SolidMolecular weight:334.35Ref: TM-T9764
1mg139.00€5mg330.00€10mg492.00€25mg797.00€50mg1,103.00€100mg1,491.00€200mg1,985.00€1mL*10mM (DMSO)340.00€CARM1-IN-3
CAS:CARM1-IN-3 (compound 17b) is a potent, selective inhibitor of co-activator associated arginine methyltransferase (CARM1), exhibiting IC50 values of 0.07 µM forFormula:C24H32N4O2Purity:98%Color and Shape:SolidMolecular weight:408.54SJ1461
CAS:SJ1461 is a potent, orally active inhibitor of the BET family, selectively targeting and inhibiting BRD2 (BD1), BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) withFormula:C21H18ClN7OS2Purity:98%Color and Shape:SolidMolecular weight:484Alobresib
CAS:Alobresib (Vorolanib) is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.Formula:C26H23N5O2Purity:97.63%Color and Shape:SolidMolecular weight:437.49Ref: TM-T8495
1mg73.00€2mg93.00€5mg144.00€10mg274.00€25mg535.00€50mg753.00€100mg1,035.00€1mL*10mM (DMSO)159.00€RBN012759
CAS:RBN012759 inhibits PARP14 protein and is more than 300-fold selective over all PARP family members.Cost-effective and quality-assured.Formula:C19H23FN2O3SPurity:98.87% - 99.96%Color and Shape:SolidMolecular weight:378.46Ref: TM-T22414
1mg105.00€5mg250.00€10mg432.00€25mg645.00€50mg938.00€100mg1,311.00€1mL*10mM (DMSO)346.00€1,5-Isoquinolinediol
CAS:1,5-Isoquinolinediol, a PARP1 inhibitor (IC50: 0.39 μM), is used in DNA repair and cell death studies.Formula:C9H7NO2Purity:99.21% - 99.43%Color and Shape:Of White To White PowderMolecular weight:161.16PROTAC SMARCA2/4-degrader-29
CAS:PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.Formula:C44H51N11O4Color and Shape:SolidMolecular weight:797.95CPI-0610 carboxylic acid
CAS:CPI-0610 carboxylic acid is a selective BET protein inhibitor with potential anticancer effects.Formula:C20H15ClN2O3Purity:98.62%Color and Shape:SolidMolecular weight:366.8Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Color and Shape:Odour SolidJAK3-IN-6
CAS:JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nMFormula:C19H18N4O3Purity:97.46% - 99.94%Color and Shape:SolidMolecular weight:350.37BRD4 Inhibitor-28
CAS:BRD4 Inhibitor-28 (Compound 18), an orally active molecule, selectively inhibits the bromodomains of BRD4 (BRD4-BD1 and BRD4-BD2) with IC50 values of 15 and 55Formula:C23H21N3O3Purity:98%Color and Shape:SolidMolecular weight:387.43PARP-1/HDAC-IN-1
CAS:PARP-1/HDAC-IN-1 is a PARP-1 and HDAC6 inhibitor with anticancer, antimigratory, and antiangiogenic activities and is used in tumor research.Formula:C22H18N4O4Purity:95.94%Color and Shape:SolidMolecular weight:402.4A-395
CAS:A-395 blocks PRC2 (EZH2-EED-SUZ12) interactions, strongly inhibiting the complex with an IC50 of 18 nM.Formula:C26H35FN4O2SPurity:97.82%Color and Shape:SolidMolecular weight:486.65JAK/HDAC-IN-2
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations.Formula:C28H38N6O5SPurity:98%Color and Shape:SolidMolecular weight:570.7PARP1-IN-33
CAS:PARP1-IN-33 (Example 6) is a PARP1 inhibitor with an IC50 of 0.41 nM. It demonstrates protective effects on retinal cells, exhibiting an EC50 of 0.02 nM in inhibiting hydrogen peroxide-induced MTS activity in human retinal pigment epithelial cells.Formula:C23H24ClFN4OColor and Shape:SolidMolecular weight:426.91
