Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
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GSK3326595
CAS:GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).Formula:C24H32N6O3Purity:97.43% - 97.7%Color and Shape:SolidMolecular weight:452.55LSD1-IN-35
CAS:LSD1-IN-35 (Compound Z-1) is a selective inhibitor of LSD1, exhibiting an IC50 of 108 nM. This compound inhibits the demethylation of H3K4me1/2 and acts as an immunomodulator. Additionally, LSD1-IN-35 enhances the responsiveness of gastric cancer cells to T-cell killing by reducing PD-L1 expression, thereby weakening the PD-1/PD-L1 interaction.Formula:C25H26N4O2SColor and Shape:SolidMolecular weight:446.57EZH2-IN-22
CAS:EZH2-IN-22 (example 92) is a potent EZH2 inhibitor, exhibiting IC50 values of <0.00051 µM for EZH2(Y641N) and EZH2(Y641F), and 0.00052 µM for EZH2 (wt). Additionally, EZH2-IN-22 demonstrates antiproliferative activity.Formula:C36H50N4O8Color and Shape:SolidMolecular weight:666.8Antitumor agent-101
CAS:Antitumor agent-101 is a selective, covalent inhibitor targeting lysine methyltransferases G9a/GLP, demonstrating IC50 values of 8.5 nM for G9a and 5.5 nM forFormula:C26H38N6O3Purity:98%Color and Shape:SolidMolecular weight:482.62Tazemetostat hydrobromide
CAS:Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).Formula:C34H45BrN4O4Purity:99.03%Color and Shape:SolidMolecular weight:653.65Ref: TM-T17002
2mg43.00€5mg60.00€10mg81.00€50mg96.00€100mg159.00€200mg230.00€500mg378.00€1mL*10mM (DMSO)84.00€PROTAC SMARCA2/4-degrader-28
CAS:PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Formula:C54H68ClN9O11S2Color and Shape:SolidMolecular weight:1118.75Talazoparib
CAS:Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).Formula:C19H14F2N6OPurity:98% - 99.92%Color and Shape:SolidMolecular weight:380.35Ref: TM-T6253
2mg42.00€5mg62.00€10mg88.00€25mg135.00€50mg187.00€100mg311.00€200mg429.00€500mg697.00€1mL*10mM (DMSO)67.00€JAK2-IN-6
CAS:JAK2-IN-6: A potent JAK2-specific inhibitor (IC50=22.86μg/mL), blocks JAK2 signaling, has anticancer properties, and is inactive against JAK1/3.Formula:C14H10ClN3OS2Purity:99.38%Color and Shape:SolidMolecular weight:335.83GSK3368715 3HCl
CAS:GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81Formula:C20H41Cl3N4O2Purity:98%Color and Shape:SolidMolecular weight:475.92WDR5-0103
CAS:WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Formula:C21H25N3O4Purity:98% - 99.61%Color and Shape:SolidMolecular weight:383.44Izencitinib
CAS:Izencitinib (JNJ-8398) is a JAK inhibitor with potential anti-inflammatory activity for the study of ulcerative colitis and Crohn;s disease.Formula:C22H26N8Purity:99.82%Color and Shape:SolidMolecular weight:402.50Ref: TM-T35898
1mg88.00€5mg187.00€10mg298.00€25mg597.00€50mg938.00€100mg1,510.00€200mg2,072.00€1mL*10mM (DMSO)207.00€SGC-iMLLT
CAS:SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 = 0.26 μM),and is a first-in-class chemical probe displaying cellular targetFormula:C22H24N6OPurity:99.21%Color and Shape:SolidMolecular weight:388.47VB1080
VB1080 (compound 12) is a potent PIM inhibitor with IC50 values of 69.5 µM for PIM1, 4996 µM for PIM2, and 9.88 µM for PIM3. Additionally, VB1080 exhibits cytotoxic properties and possesses anthelmintic activity.Formula:C27H27N3O3Molecular weight:441.522SMARCA2-IN-6
CAS:SMARCA2-IN-6 is a potent inhibitor of SMARCA2 (also known as BRM), exhibiting an IC50 of less than 5 nM against both SMARCA2 and SMARCA4. Additionally, this compound suppresses the expression of the KRT80 gene in H1299 cells with an IC50 of 26 nM and inhibits the proliferation of SKMEL5 cells carrying a BRG1 mutation with an IC50 value of 13 nM.Formula:C10H8ClF2N5OSColor and Shape:SolidMolecular weight:319.72(R)-UT-155
CAS:(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.Formula:C20H15F4N3O2Color and Shape:SolidMolecular weight:405.35Enarodustat
CAS:Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.Formula:C17H16N4O4Purity:99.14% - 99.61%Color and Shape:SolidMolecular weight:340.33Ref: TM-T15219
1mg39.00€2mg50.00€5mg79.00€10mg115.00€25mg188.00€50mg311.00€100mg462.00€1mL*10mM (DMSO)90.00€SP-96
CAS:SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.Formula:C25H20FN7OPurity:99.52%Color and Shape:SolidMolecular weight:453.47Ref: TM-T41256
1mg73.00€5mg160.00€10mg250.00€25mg445.00€50mg625.00€100mg909.00€200mg1,216.00€1mL*10mM (DMSO)170.00€ML324
CAS:ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).Formula:C21H23N3O2Purity:98.22% - 98.57%Color and Shape:SolidMolecular weight:349.43Anti-PARP1 Antibody (8S756)
Anti-PARP1 Antibody (8S756) is an antibody targeting PARP1. Anti-PARP1 Antibody (8S756) can be used in ELISA, WB, IHC, IF, FCM.Color and Shape:Odour LiquidValemetostat tosylate
CAS:Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.Formula:C33H42ClN3O7SPurity:98%Color and Shape:SolidMolecular weight:660.22
