Chromatin/Epigenetics
Chromatin/epigenetics inhibitors are compounds that modulate the structure and function of chromatin or interfere with epigenetic modifications, such as DNA methylation and histone modification. These inhibitors are essential tools for studying gene expression regulation and the role of epigenetics in diseases like cancer, neurological disorders, and developmental abnormalities. By targeting epigenetic processes, these inhibitors can alter gene expression patterns and offer new therapeutic avenues. At CymitQuimica, we provide a wide selection of high-quality chromatin/epigenetics inhibitors to support your research in molecular biology, genetics, and epigenetics.
Subcategories of "Chromatin/Epigenetics"
Products of "Chromatin/Epigenetics"
Sort by
Lomeguatrib
CAS:Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .Formula:C10H8BrN5OSPurity:99.26% - 99.62%Color and Shape:SolidMolecular weight:326.17AGI-25696
CAS:AGI-25696 inhibits MATA2, blocking MTAP-deleted tumor growth, potential for cancer research.Formula:C27H18N4OPurity:99.08% - 99.74%Color and Shape:SolidMolecular weight:414.46PARP1-IN-29
CAS:PARP1-IN-29 is an orally active PARP-1 inhibitor with an IC50 of 6.3 nM. When labeled with [18F], PARP1-IN-29 can be utilized for positron emission tomography (PET) imaging, specifically targeting PARP-1 in tumors. This compound is useful in oncology and imaging studies, particularly for detecting PARP-1 activity in cancer.Formula:C18H16FN3O2Color and Shape:SolidMolecular weight:325.34Isomaltotriose
CAS:Isomaltotriose is a sugar compound derived from the enzymic hydrolyzates of dextran obtained from the Leuconostoc mesenteroides NRRL B-512.Formula:C18H32O16Purity:98%Color and Shape:Lyophilized PowderMolecular weight:504.44HIV-IN-7
Axl-IN-16 (Compound 4), an Axl inhibitor, not only suppresses Axl expression and HIF activity but also triggers fruiting body formation in Flammulina velutipes.Formula:C32H61N3O10P2Purity:98%Color and Shape:SolidMolecular weight:709.79BRD4 degrader AT1
CAS:BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.Formula:C48H58ClN9O5S3Purity:98%Color and Shape:SolidMolecular weight:972.68BAY-598
CAS:BAY 598 is a potent and selective competitive inhibitor of SMYD2, exhibiting >100-fold selectivity over SMYD3, SUV420H1, and SUV420H2. Cost-effective and quality-assured.Formula:C22H20Cl2F2N6O3Purity:98.68% - 99.18%Color and Shape:SolidMolecular weight:525.34HIF-2α-IN-9
CAS:HIF-2α-IN-9 (compound 35r) serves as an HIF-2α inhibitor, effectively suppressing VEGF-A with an IC50 of 305 nM, and modulating growth-promoting genes withinFormula:C12H13F5O4S2Purity:98%Color and Shape:SolidMolecular weight:380.35SRI-42127
CAS:SRI-42127 is a novel small molecule inhibitor of the RNA regulatory factor HuR that inhibits tumor growth and reduces neuropathic pain following nerve injury.Formula:C19H20N6OPurity:99.66%Color and Shape:SolidMolecular weight:348.4JAK-IN-30
CAS:JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50Formula:C19H26N8SPurity:98%Color and Shape:SolidMolecular weight:398.53GS-829845
CAS:GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-lifeFormula:C17H19N5O2SPurity:99.78%Color and Shape:SolidMolecular weight:357.43Brepocitinib P-Tosylate
CAS:Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).Formula:C25H29F2N7O4SPurity:99.82% - 99.97%Color and Shape:SolidMolecular weight:561.6PROTAC SMARCA2 degrader-21
CAS:PROTAC SMARCA2 degrader-21 (Compound I-5) acts as a degrader of SMARCA2 in A549 cells, with a DC50 range of 10-50 nM, and additionally degrades both SMARCA2 and SMARCA4 in MV411 cells, with respective DC50 values of <1 nM and >100 nM.Formula:C54H66N12O5SColor and Shape:SolidMolecular weight:995.24CeMMEC1
CAS:CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).Formula:C19H16N2O4Purity:100% - 99.26%Color and Shape:SolidMolecular weight:336.34CPI203
CAS:CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).Formula:C19H18ClN5OSPurity:99.13% - 99.71%Color and Shape:SolidMolecular weight:399.911α-O-Tigloyl-12β-O-acetyltenacigenin B
CAS:11α-O-Tigloyl-12β-O-acetyltenacigenin B, an ester derivative isolated from Garcinia cambogia (MTC), modulates the antitumor effects of Aurora-A in lymphomaFormula:C28H40O7Purity:98%Color and Shape:SolidMolecular weight:488.61JAK-IN-25
CAS:JAK-IN-25 (compound 19), a potent JAK inhibitor, exhibits IC50 values of 6 nM for TYK2, 21 nM for JAK1, 8 nM for JAK2, and 1051 nM for JAK3.Formula:C19H17N5O4Purity:98%Color and Shape:SolidMolecular weight:379.37T-448 free base
CAS:T-448 free base is a specific, orally active and irreversible lysine-specific demethylase 1 (LSD1, an H3K4 demethylase) inhibitor(IC50 of 22 nM).Formula:C17H20N4OSPurity:98%Color and Shape:SolidMolecular weight:328.43ORIC-944
CAS:ORIC-944 is an orally available, selective variant of PRC2 with anticancer activity for the study of prostate cancer.Formula:C26H25FN6OPurity:98.08%Color and Shape:SolidMolecular weight:456.52PARP-1/2-IN-2
PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repairFormula:C25H23IN8O3Purity:98%Color and Shape:SolidMolecular weight:610.41
