MAPK
MAPKs are a family of protein kinases involved in a variety of cellular processes, including growth, proliferation, differentiation, and stress responses. The MAPK signaling pathway consists of several tiers, including ERK, JNK, and p38 MAPKs, each playing distinct roles in cellular function. Dysregulation of MAPK signaling is linked to cancer, inflammatory diseases, and metabolic disorders. At CymitQuimica, we offer a wide array of MAPK inhibitors and activators to support your research in cell biology, signal transduction, and disease mechanisms.
Products of "MAPK"
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CHPG hydrochloride
CHPG hydrochloride is a selective agonist of mGluR5.Formula:C8H9Cl2NO3Purity:98.1%Color and Shape:SoildMolecular weight:238.07Ref: TM-T10809L
1mg56.00€5mg116.00€10mg168.00€25mg269.00€50mg383.00€100mg510.00€200mg692.00€1mL*10mM (DMSO)101.00€SB 202190 hydrochloride
CAS:SB 202190 hydrochloride is a p38 MAPK inhibitor that inhibits p38α and p38β2 with selective, cell-permeable, and antitumor ,differentiation to cardiomyocytes.Formula:C20H15ClFN3OPurity:99.99%Color and Shape:SolidMolecular weight:367.8Ref: TM-T35592
2mg49.00€5mg66.00€10mg90.00€25mg145.00€50mg207.00€100mg309.00€200mg459.00€1mL*10mM (DMSO)71.00€Raf inhibitor 3
CAS:Raf inhibitor 3 (Example 30), a potent inhibitor of both B-Raf and C-Raf, exhibits IC50 values below 15 nM. It is applicable in cancer research studies [1].Formula:C18H19FN8O2SPurity:98%Color and Shape:SolidMolecular weight:430.46Lupalbigenin
CAS:Lupalbigenin sensitizes detachment-induced cell death in human lung cancer cell through down-regulation of pro-survival proteins.Formula:C25H26O5Purity:98%Color and Shape:SolidMolecular weight:406.47Xl-281
CAS:XL-281: potent oral RAF kinase inhibitor, effective on wild-type and mutants, reduces tumor growth and cell proliferation, increases apoptosis.Formula:C24H19ClN4O4Purity:95.77% - 98.60%Color and Shape:SolidMolecular weight:462.89ERK5-IN-5
CAS:ERK5-IN-5 is extracellular signal-regulated kinase 5 (ERK5) inhibitor with anticancer activity anticonvulsant activity inhibits A549 cell proliferation.Formula:C19H16ClN3OPurity:99.77%Color and Shape:SoildMolecular weight:337.8Ref: TM-T77734
1mg86.00€2mg111.00€5mg180.00€10mg279.00€25mg562.00€50mg917.00€100mg1,454.00€500mg2,822.00€Farrerol
CAS:Farrerol shows antioxidative effects, modulates genes, fights S. aureus in cows, protects cells, and may prevent heart disease.Formula:C17H16O5Purity:99.89% - 99.96%Color and Shape:SolidMolecular weight:300.31Ref: TM-T6S0525
2mg43.00€5mg59.00€10mg85.00€25mg120.00€50mg170.00€100mg253.00€200mg375.00€1mL*10mM (DMSO)71.00€B-Raf IN 16
CAS:B-Raf IN 16, a BRAF inhibitor, belongs to cyclic iminopyrimidine derivatives and can be used for cancer or tumour research.Formula:C20H19N5O3SPurity:98.59% - 99.56%Color and Shape:SolidMolecular weight:409.46Gardenin A
CAS:Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.Formula:C21H22O9Purity:95.15% - 95.15%Color and Shape:SolidMolecular weight:418.39Ref: TM-TN4114
1mg187.00€5mg467.00€10mg693.00€25mg1,074.00€50mg1,454.00€100mg1,882.00€500mg3,924.00€1mL*10mM (DMSO)502.00€1-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Formula:C9H10O2SPurity:99.48%Color and Shape:SolidMolecular weight:182.24Ref: TM-T8870
1mg51.00€5mg153.00€10mg207.00€25mg288.00€50mg404.00€100mg562.00€200mg758.00€1mL*10mM (DMSO)101.00€p38-α MAPK-IN-10
CAS:p38-α MAPK-IN-10 (Compound 6) is an inhibitor of p38α, with an IC50 value of 4 nM.Formula:C27H34Cl2N6Color and Shape:SolidMolecular weight:513.505Corylifol C
CAS:Corylifol C and, to a lesser extent, xanthoangelol are potent protein kinase inhibitors (inhibitory concentration 50% values for epidermal growth factorFormula:C20H18O5Purity:98%Color and Shape:SolidMolecular weight:338.35SOS1-IN-17
SOS1-IN-17 (Compound 8d) is an orally active inhibitor targeting the SOS1-KRASG12C interaction, with an IC50 of 5.1 nM. It suppresses ERK phosphorylation in DLD-1 cells with an IC50 of 18 nM and demonstrates antiproliferative activity in KRASG12C-mutant Mia-Paca-2 cells, with an IC50 of 0.11 μM. In mouse models, SOS1-IN-17 shows antitumor efficacy against pancreatic cancer.Formula:C29H34F3N5O2Color and Shape:SolidMolecular weight:541.61JWG-071
CAS:JWG-071: First ERK5 kinase probe, BET inhibitor, 1 μM BRD4 IC, boosts ERK5 function and BRD4 selectivity.Formula:C34H44N8O3Purity:98.33%Color and Shape:SolidMolecular weight:612.77Rasarfin
CAS:Rasarfin inhibits Ras and ARF6.Formula:C23H24ClN3O3Purity:97.98%Color and Shape:SolidMolecular weight:425.91Ref: TM-T9407
1mg40.00€5mg80.00€10mg116.00€25mg205.00€50mg340.00€100mg485.00€200mg655.00€1mL*10mM (DMSO)88.00€DB07268
CAS:DB07268 is a potent and selective JNK1 inhibitor.Formula:C17H15N5O2Purity:98.2% - 98.91%Color and Shape:SolidMolecular weight:321.33Laxiflorin B-4
Laxiflorin B-4, a derivative of Laxiflorin B, demonstrates increased affinity for ERK1/2 and enhanced tumor-suppressive effects [1].Purity:98%Color and Shape:Odour SolidPS-166276
CAS:PS-166276 is a potent p38 inhibitor with low cytotoxicity. It exhibits an IC50 value of 28 nM against p38 kinase and an IC50 of 170 nM in the THP-1 TNFα assay.Formula:C20H30N8OColor and Shape:SolidMolecular weight:398.51NCB-0846
CAS:NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).Formula:C21H21N5O2Purity:97.04% - 99.46%Color and Shape:SolidMolecular weight:375.42LJI308
CAS:LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.Formula:C21H18F2N2O2Purity:98.86% - 99.73%Color and Shape:SolidMolecular weight:368.38
