P-gp
P-glycoprotein is an ATP-dependent efflux pump that transports a wide variety of substrates, including drugs, toxins, and lipids, out of cells. It plays a critical role in drug resistance, particularly in cancer, by reducing the intracellular concentration of chemotherapeutic agents. P-gp is also involved in the blood-brain barrier, influencing the central nervous system's exposure to various compounds. At CymitQuimica, we provide a range of P-gp modulators to support your research in drug resistance, pharmacokinetics, and therapeutic development.
Products of "P-gp"
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Encequidar
CAS:Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.Formula:C38H36N6O7Purity:99.93%Color and Shape:SolidMolecular weight:688.73Ref: TM-T8426
1mg48.00€2mg65.00€5mg96.00€10mg144.00€25mg246.00€50mg380.00€100mg557.00€1mL*10mM (DMSO)134.00€Phellamurin
CAS:Phellamurin blocks intestinal P-glycoprotein dose-dependently and it seriously interacts with cyclosporin; coadministration should be avoided.Formula:C26H30O11Purity:93.19% - 93.19%Color and Shape:SolidMolecular weight:518.51Ref: TM-TN4761
1mg163.00€5mg320.00€10mg472.00€25mg753.00€50mg1,074.00€100mg1,444.00€1mL*10mM (DMSO)410.00€HM-30181 mesylate monohydrate
CAS:HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.Formula:C39H42N6O11SPurity:99.37%Color and Shape:SolidMolecular weight:802.85Ref: TM-T9173
1mg69.00€2mg88.00€5mg126.00€10mg195.00€25mg325.00€50mg467.00€100mg680.00€200mg882.00€500mg1,320.00€1mL*10mM (DMSO)187.00€Elacridar
CAS:Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.Formula:C34H33N3O5Purity:100% - 99.62%Color and Shape:SolidMolecular weight:563.64Ref: TM-T2657
5mg42.00€10mg63.00€25mg107.00€50mg188.00€100mg283.00€200mg472.00€500mg753.00€1mL*10mM (DMSO)57.00€Tariquidar methanesulfonate hydrate
CAS:m-PEG8-Ms is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC compounds.Formula:C40H58N4O18S2Purity:98.13%Color and Shape:SolidMolecular weight:947.04Solamargine
CAS:Solamargine, a steroidal alkaloid from Solanum nigrum, inhibits cancer cell growth and induces apoptosis.Formula:C45H73NO15Purity:99.17% - 99.88%Color and Shape:SolidMolecular weight:868.06Norverapamil hydrochloride
CAS:Norverapamil HCl, a Verapamil metabolite, blocks L-type calcium channels and inhibits P-gp function.Formula:C26H37ClN2O4Purity:99.47%Color and Shape:SolidMolecular weight:477.04Ref: TM-T16339
1mg37.00€5mg111.00€10mg187.00€25mg315.00€50mg472.00€100mg658.00€500mg1,378.00€1mL*10mM (DMSO)116.00€HTT-D3
CAS:HTT-D3 is a Huntington splicing regulator that induces HTT mRNA degradation, leading to a reduction in HTT protein levels.Formula:C23H25FN6Purity:99.31%Color and Shape:SolidMolecular weight:404.48coniferyl ferulate
CAS:Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis.Formula:C20H20O6Purity:97.09%Color and Shape:SolidMolecular weight:356.37MCI826
CAS:MCI826 is a potent and selective antagonist of P-glycoprotein (P-gp) and peptide leukotrienes (p-LTs), showing anti-asthmatic activity in a guinea pig model ofFormula:C22H28N2O3SPurity:98.73%Color and Shape:SolidMolecular weight:400.53Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.Formula:C51H82O21Purity:99.51% - 99.63%Color and Shape:SolidMolecular weight:1031.18Valspodar
CAS:Valspodar (PSC 833) is a specific P-glycoprotein inhibitor and MDR regulator often used as a chemical sensitizer to study advanced epithelial ovarian cancer.Formula:C63H111N11O12Purity:100% - 95%Color and Shape:SolidMolecular weight:1214.62Hypophyllanthin
CAS:Hypophyllanthin and phyllanthin have antitumour effects against Ehrlich Ascites Carcinoma in mice.Formula:C24H30O7Purity:98.39%Color and Shape:SolidMolecular weight:430.49Polyoxyethylene stearate
CAS:Polyoxyethylene stearate (POES) is an agent of non-ionic emulsifying.Formula:C20H40O3Purity:n~9-10Color and Shape:Light Amber SemisolidMolecular weight:328.29775Risperidone
CAS:Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.Formula:C23H27FN4O2Purity:99.73%Color and Shape:Crystalline SolidMolecular weight:410.48Sinapine thiocyanate
CAS:Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds.Formula:C16H24NO5·CNSPurity:98.19% - ≥95%Color and Shape:SolidMolecular weight:368.45Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Formula:C23H28ClN3O5SPurity:99.05% - 99.75%Color and Shape:SolidMolecular weight:494P-gp inhibitor 1
CAS:P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562/A02 cells).Formula:C32H31N5O2Purity:98.65%Color and Shape:SolidMolecular weight:517.62Ref: TM-T12341
5mg50.00€10mg84.00€25mg150.00€50mg219.00€100mg304.00€200mg419.00€1mL*10mM (DMSO)58.00€Piperine
CAS:Piperine (Bioperine) , a alkaloid, has been used in trials studying the treatment of multiple myeloma and deglutition disorders.Formula:C17H19NO3Purity:100% - 97.79%Color and Shape:SolidMolecular weight:285.34γ-Tocotrienol
CAS:γ-Tocotrienol (Plastochromanol) is one of the four types of tocotrienol, a type of vitamin E.Formula:C28H42O2Purity:97.27% - 98.13%Color and Shape:SolidMolecular weight:410.63Ref: TM-T19768
1mg47.00€2mg62.00€5mg92.00€10mg144.00€25mg235.00€50mg350.00€100mg515.00€200mg743.00€1mL*10mM (DMSO)97.00€
