PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Products of "PDE"
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Olprinone
CAS:Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuateFormula:C14H10N4OPurity:99.68%Color and Shape:SolidMolecular weight:250.26Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Formula:C24H28N2O6SPurity:98.75% - 99.74%Color and Shape:SolidMolecular weight:472.55Anagrelide
CAS:Anagrelide (Xagrid) is a Platelet-reducing Agent.Formula:C10H7Cl2N3OPurity:100%Color and Shape:SolidMolecular weight:256.09Balipodect
CAS:Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.Formula:C23H17FN6O2Purity:98.32% - 98.97%Color and Shape:SolidMolecular weight:428.42Ref: TM-T1745
1mg38.00€2mg49.00€5mg79.00€10mg93.00€25mg156.00€50mg256.00€100mg444.00€1mL*10mM (DMSO)79.00€TPN171
CAS:TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonaryFormula:C24H35N5O3Purity:100%Color and Shape:SolidMolecular weight:441.57PQ-10
CAS:PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.Formula:C22H21N5O3Purity:99.30%Color and Shape:SolidMolecular weight:403.43Ref: TM-T24656
2mg34.00€5mg52.00€10mg85.00€25mg170.00€50mg259.00€100mg374.00€200mg545.00€1mL*10mM (DMSO)57.00€Mirodenafil dihydrochloride
CAS:Mirodenafil dihydrochloride is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.Formula:C26H39Cl2N5O5SPurity:99.64% - 99.78%Color and Shape:SolidMolecular weight:604.59Bay 60-7550
CAS:Bay 60-7550 is a PDE2 inhibitor that exerts positive inotropic effects in the rat heart by increasing PKA-mediated phosphorylation.Formula:C27H32N4O4Purity:98.14%Color and Shape:SolidMolecular weight:476.57ENPP1 Inhibitor C
CAS:ML-354 (VU0099704) is an antagonist with and PAR4 for the study of cardiovascular diseases.Formula:C15H18N6Color and Shape:SolidMolecular weight:282.34Vardenafil dihydrochloride
CAS:Vardenafil dihydrochloride (Levitra) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.Formula:C23H34Cl2N6O4SPurity:98%Color and Shape:SolidMolecular weight:561.52Enoximone
CAS:Enoximone is a selective inhibitor of phosphodiesterase III (PDE3), with treatment of congestive heart failure.Formula:C12H12N2O2SPurity:95.52%Color and Shape:SolidMolecular weight:248.3KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Formula:C25H35N7O6SPurity:99.55%Color and Shape:SolidMolecular weight:561.65MY-5445
CAS:MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) is a specific inhibitor of phosphodiesterase type 5 (PDE5).Formula:C20H14ClN3Purity:99.77%Color and Shape:SolidMolecular weight:331.8BW-A 78U
CAS:BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.Formula:C13H12FN5Purity:99.45%Color and Shape:SolidMolecular weight:257.27Ref: TM-T5101
1mg39.00€5mg101.00€10mg153.00€25mg249.00€50mg359.00€100mg507.00€200mg695.00€1mL*10mM (DMSO)44.00€Piclamilast
CAS:Piclamilast (RP 73401) is a PDE4 inhibitor.Formula:C18H18Cl2N2O3Purity:98.28%Color and Shape:SolidMolecular weight:381.25Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Formula:C15H20N2O4Purity:98.44% - 99.64%Color and Shape:SolidMolecular weight:292.33Ref: TM-T31792
1mg226.00€5mg552.00€10mg735.00€25mg1,111.00€50mg1,491.00€100mg2,005.00€200mg2,707.00€1mL*10mM (DMSO)500.00€Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Formula:C15H15ClN4OPurity:99.93%Color and Shape:SolidMolecular weight:302.76Ensifentrine
CAS:Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), thatFormula:C26H31N5O4Purity:98.45% - 99.94%Color and Shape:SolidMolecular weight:477.56Ref: TM-T25376
1mg35.00€5mg96.00€10mg160.00€25mg329.00€50mg533.00€100mg847.00€200mg1,159.00€1mL*10mM (DMSO)105.00€Lodenafil
CAS:Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)Formula:C23H32N6O5SPurity:99.92%Color and Shape:SolidMolecular weight:504.6Ref: TM-T7346
2mg35.00€5mg50.00€10mg81.00€25mg129.00€50mg187.00€100mg259.00€200mg373.00€1mL*10mM (DMSO)56.00€BAY 2666605
CAS:BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.Formula:C17H12F4N2O2Purity:99.98%Color and Shape:SolidMolecular weight:352.28Ref: TM-T9805
1mg97.00€5mg235.00€10mg376.00€25mg828.00€50mg1,320.00€100mg2,118.00€1mL*10mM (DMSO)259.00€
