PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Products of "PDE"
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Zatolmilast
CAS:Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).Formula:C21H15ClF3NO2Purity:98.20%Color and Shape:SolidMolecular weight:405.8Ref: TM-T10590
1mg70.00€5mg135.00€10mg245.00€25mg409.00€50mg562.00€100mg780.00€200mg1,026.00€1mL*10mM (DMSO)149.00€Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Formula:C23H24F2N2O5Purity:99.04%Color and Shape:SolidMolecular weight:446.44Ref: TM-T27172
1mg69.00€5mg149.00€10mg235.00€25mg469.00€50mg753.00€100mg1,216.00€1mL*10mM (DMSO)164.00€Vardenafil hydrochloride
CAS:Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor, in the Treatment of Erectile Dysfunction in Men With DiabetesFormula:C23H33ClN6O4SPurity:99.76% - 99.86%Color and Shape:White To Off-White Cyrstalline SolidMolecular weight:525.06TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Formula:C26H19F3N4OPurity:98.48%Color and Shape:SolidMolecular weight:460.45Ref: TM-T13189
1mg92.00€2mg120.00€5mg187.00€10mg279.00€25mg487.00€50mg705.00€100mg998.00€500mg1,882.00€1mL*10mM (DMSO)188.00€Tanimilast
CAS:Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.Formula:C30H30Cl2F2N2O8SPurity:98.3%Color and Shape:SolidMolecular weight:687.54PDE5-IN-9
CAS:WAY-639921 treats cardiovascular and respiratory conditions by inhibiting PDE1c.Formula:C18H14N4SPurity:100%Color and Shape:SolidMolecular weight:318.4K-Ras-PDEδ-IN-1
CAS:K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).Formula:C25H26FN5O2Purity:99.48%Color and Shape:SolidMolecular weight:447.5Isomazole
CAS:Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.Formula:C14H13N3O2SPurity:99.12%Color and Shape:SolidMolecular weight:287.34Cilostazol
CAS:Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.Formula:C20H27N5O2Purity:99.58% - 99.90%Color and Shape:Off-White SolidMolecular weight:369.46Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Formula:C15H15N3OPurity:99.11%Color and Shape:SolidMolecular weight:253.3EMD57439
CAS:EMD57439 is a selective PDE-III inhibitor, showing no significant increase in c-AMP concentration and producing little change in Ca(50).Formula:C22H23N3O4SPurity:98% - 99.38%Color and Shape:SolidMolecular weight:425.5MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Formula:C25H18N4O3Purity:99.29%Color and Shape:SolidMolecular weight:422.44Anagrelide hydrochloride
CAS:Anagrelide hydrochloride (BL4162A) serves as a treatment for essential thrombocytosis.Formula:C10H7Cl2N3O·HClPurity:99.58%Color and Shape:Off-White PowderMolecular weight:292.55Oglemilast
CAS:Oglemilast (GRC 3886) suppresses pulmonary cell infiltration, including eosinophilia and neutrophilia in vitro and in vivo.Formula:C20H13Cl2F2N3O5SPurity:98.11%Color and Shape:SolidMolecular weight:516.3Anti-ALDH7A1 Antibody (1G435)
Anti-ALDH7A1 Antibody (1G435) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (1G435) can be used in ELISA.Color and Shape:Odour LiquidTAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Formula:C19H18F4N4O5Purity:98%Color and Shape:SolidMolecular weight:458.36Crisaborole
CAS:Crisaborole (AN-2728) is a Phosphodiesterase 4 Inhibitor.Formula:C14H10BNO3Purity:99.70%Color and Shape:SolidMolecular weight:251.05Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Formula:C21H15Cl2F2N3O2SPurity:98.84%Color and Shape:SolidMolecular weight:482.33Ref: TM-T63190
1mg77.00€5mg170.00€10mg248.00€25mg444.00€50mg662.00€100mg929.00€200mg1,225.00€1mL*10mM (DMSO)170.00€Ibudilast
CAS:Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.Formula:C14H18N2OPurity:99.34% - 99.94%Color and Shape:White SolidMolecular weight:230.31Enpp-1-IN-14
CAS:Enpp-1-IN-14: potent ENPP1 inhibitor, IC50 = 32.38 nM, exhibits anti-tumor properties.Formula:C15H22ClN5O4SPurity:100%Color and Shape:SoildMolecular weight:403.88
