PDE
Phosphodiesterases (PDEs) are enzymes that hydrolyze cyclic nucleotides, such as cAMP and cGMP, into their inactive forms, playing a key role in regulating intracellular signaling pathways. PDE inhibitors are used in the treatment of various conditions, including cardiovascular diseases, erectile dysfunction, and respiratory disorders, due to their ability to modulate cyclic nucleotide levels. At CymitQuimica, we provide a range of PDE inhibitors to support your research in cell signaling, pharmacology, and therapeutic development.
Products of "PDE"
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Carbazeran
CAS:Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.Formula:C18H24N4O4Purity:97.28%Color and Shape:SolidMolecular weight:360.41Autotaxin modulator 1
CAS:Autotaxin modulator 1 is a new modulator of Autotaxin.Formula:C28H31F6NO3Color and Shape:SolidMolecular weight:543.54Osoresnontrine
CAS:Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.Formula:C16H17N5O2Purity:99.93%Color and Shape:SolidMolecular weight:311.34Ref: TM-T8515
1mg38.00€2mg50.00€5mg81.00€10mg119.00€25mg188.00€50mg350.00€100mg522.00€200mg748.00€1mL*10mM (DMSO)89.00€PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFormula:C20H23ClN4O2Purity:98.57%Color and Shape:SolidMolecular weight:386.88Ref: TM-T10201
1mg341.00€5mg723.00€10mg969.00€25mg1,454.00€50mg1,948.00€100mg2,632.00€1mL*10mM (DMSO)815.00€ALDH7A1 Protein, Human, Recombinant (His)
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family.Color and Shape:Lyophilized PowderMolecular weight:56 kDa (predicted); 56 kDa (reducing conditions)Anti-ALDH7A1 Antibody (6G475)
Anti-ALDH7A1 Antibody (6G475) is a Mouse antibody targeting ALDH7A1. Anti-ALDH7A1 Antibody (6G475) can be used in IHC-P.Color and Shape:Odour LiquidRS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Formula:C19H13N5O4Purity:98.98%Color and Shape:SolidMolecular weight:375.34Ref: TM-T9239
1mg88.00€5mg172.00€10mg259.00€25mg425.00€50mg598.00€100mg810.00€200mg1,074.00€1mL*10mM (DMSO)187.00€ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Formula:C22H18ClF3N6OPurity:99.23%Color and Shape:SolidMolecular weight:474.87Ref: TM-T10409
1mg64.00€5mg140.00€10mg219.00€25mg373.00€50mg510.00€100mg695.00€200mg937.00€1mL*10mM (DMSO)145.00€PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Formula:C14H11ClN2O3SPurity:98%Color and Shape:SolidMolecular weight:322.77IBMX
CAS:IBMX (Methylisobutylxanthine) is a broad-spectrum phosphodiesterase (PDE) inhibitor with inhibitory activity against PDE3, PDE4, and PDE5 (IC50=6.5/26.3/31.7 μMFormula:C10H14N4O2Purity:100% - 99.99%Color and Shape:Off-WhiteMolecular weight:222.24GSK256066
CAS:GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-foldFormula:C27H26N4O5SPurity:99.52% - 99.66%Color and Shape:SolidMolecular weight:518.58PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Formula:C17H23FN6O2Purity:100%Color and Shape:SolidMolecular weight:362.4Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Formula:C22H21N9O2Purity:98%Color and Shape:SolidMolecular weight:443.46PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Formula:C18H20ClN5OPurity:98.75%Color and Shape:SolidMolecular weight:357.84Ref: TM-T28352
1mg39.00€5mg73.00€10mg94.00€25mg153.00€50mg219.00€100mg325.00€200mg465.00€1mL*10mM (DMSO)84.00€Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Formula:C16H14N4OPurity:100% - 99.61%Color and Shape:SolidMolecular weight:278.31Ref: TM-T23638
1mg115.00€2mg172.00€5mg255.00€10mg375.00€25mg562.00€50mg792.00€100mg1,064.00€500mgTo inquire1mL*10mM (DMSO)240.00€PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Formula:C19H17ClN2O2Purity:100%Color and Shape:SolidMolecular weight:340.8Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Formula:C26H24N4O5Purity:97.03% - 99.29%Color and Shape:SolidMolecular weight:472.49Ref: TM-T3987
1mg34.00€2mg47.00€5mg70.00€10mg96.00€25mg170.00€50mg298.00€100mg430.00€200mg607.00€1mL*10mM (DMSO)71.00€HA130
CAS:HA130 is a selective ATX (autotaxin) inhibitor.Formula:C24H19BFNO5SPurity:100% - ≥95%Color and Shape:SolidMolecular weight:463.29Ref: TM-T2646
2mg39.00€5mg57.00€10mg93.00€25mg145.00€50mg235.00€100mg351.00€200mg528.00€1mL*10mM (DMSO)58.00€ICI 63197
CAS:ICI 63197 (2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one) is a PDE4 inhibitor.Formula:C9H13N5OPurity:99.02%Color and Shape:White SolidMolecular weight:207.23PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Formula:C19H18ClN3O2SPurity:99.37%Color and Shape:SolidMolecular weight:387.88Ref: TM-T36832
1mg37.00€5mg79.00€10mg111.00€25mg216.00€50mg354.00€100mg567.00€500mg1,198.00€1mL*10mM (DMSO)87.00€
