HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Products of "HIF/HIF Prolyl-Hydroxylase"
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HIF-2α-IN-2
CAS:HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).Formula:C17H13F2NO4SPurity:99.24%Color and Shape:SolidMolecular weight:365.35Ref: TM-T11561
1mg71.00€5mg135.00€10mg178.00€25mg309.00€50mg447.00€100mg620.00€200mg835.00€1mL*10mM (DMSO)149.00€JPHM-2-167
CAS:PHM-2-167 (Compound 11) is a selective inhibitor of the prolyl hydroxylase domain enzyme (PHD). It inhibits PHD2 and PHD3 with IC50 values of 0.253 μM and 3.95 μM, respectively. PHM-2-167 is applicable for research in chronic kidney disease.Formula:C30H28N6O2Color and Shape:SolidMolecular weight:504.582PHD-IN-1
CAS:PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Formula:C24H23N7O2Purity:98%Color and Shape:SolidMolecular weight:441.49HIF-2α-IN-3
CAS:HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.Formula:C12H6ClN5O5Purity:98.11%Color and Shape:SolidMolecular weight:335.66Ref: TM-T11562
1mg115.00€5mg274.00€10mg432.00€25mg845.00€50mg1,293.00€100mg1,768.00€1mL*10mM (DMSO)303.00€HNHA
CAS:HNHA is an inhibitor of HDAC.Formula:C17H21NO2SPurity:98.04%Color and Shape:SolidMolecular weight:303.42Ref: TM-T21806
1mg44.00€5mg84.00€10mg135.00€25mg279.00€50mg445.00€100mg640.00€200mg879.00€1mL*10mM (DMSO)90.00€Panaxadiol
CAS:Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.Formula:C30H52O3Purity:98% - 99.9%Color and Shape:SolidMolecular weight:460.73HIF-1α-IN-2
CAS:HIF-1α-IN-2 is a HIF-1α inhibitor with anticancer activity that inhibits the expression of HIF-1α and VEGF, and inhibits cell migration.Formula:C21H19N3OSPurity:98.45%Color and Shape:SolidMolecular weight:361.46HIF-2α agonist 2
CAS:HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α.Formula:C13H8Br2N2O2SPurity:98.32%Color and Shape:SoildMolecular weight:416.09Albendazole
CAS:Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.Formula:C12H15N3O2SPurity:98.21% - 98.76%Color and Shape:Colorless Crystals SolidMolecular weight:265.33JNJ-42041935
CAS:JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.Formula:C12H6ClF3N4O3Purity:99.58% - ≥95%Color and Shape:SolidMolecular weight:346.65Ref: TM-T3180
1mg40.00€2mg52.00€5mg88.00€10mg119.00€25mg210.00€50mg354.00€100mg567.00€500mg1,198.00€1mL*10mM (DMSO)87.00€Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formula:C16H12O5Purity:98.72% - 99.55%Color and Shape:SolidMolecular weight:284.26PT2399
CAS:PT2399, an oral HIF-2 inhibitor, blocks HIF-2α/1β dimerization, showing strong in vivo antitumor effects.Formula:C17H10F5NO4SPurity:98.8% - 99.07%Color and Shape:SolidMolecular weight:419.32Ref: TM-T12675L
1mg99.00€5mg235.00€10mg354.00€25mg640.00€50mg944.00€100mg1,320.00€1mL*10mM (DMSO)259.00€ML228
CAS:ML228 activates HIF pathway and VEGF, with EC50 of 1μM, effective in vitro.Formula:C27H21N5Purity:99.03%Color and Shape:SolidMolecular weight:415.49VHL-IN-1
VHL-IN-1 (compound 30), a ubiquitin E3 ligase von Hippel-Lindau (VHL) inhibitor with a dissociation constant (Kd) of 37 nM, potently stabilizes HIF-1α andFormula:C28H37FN4O4SPurity:98%Color and Shape:SolidMolecular weight:544.68Deferoxamine Mesylate
CAS:Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.Formula:C26H52N6O11SPurity:94.68% - 99.80%Color and Shape:SolidMolecular weight:656.79Chlorogenic Acid
CAS:Chlorogenic acid is a natural phenol. Chlorogenic acid has anti-inflammatory, antitumor, and antimicrobial effects. Cost-effective and quality-assured.Formula:C16H18O9Purity:98.76% - 99.67%Color and Shape:SolidMolecular weight:354.31Minocycline hydrochloride
CAS:Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.Formula:C23H28ClN3O7Purity:100% - 99.89%Color and Shape:Bright Yellow-Orange Amorphous Solid Crystalline YellowMolecular weight:493.94Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Formula:C6H13NO5·H2SO4Purity:99.64%Color and Shape:White CrystalMolecular weight:277.25HIF-2α-IN-1
CAS:HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.Formula:C16H8F5NO4SPurity:97.99%Color and Shape:SolidMolecular weight:405.3Roxadustat
CAS:Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity.Formula:C19H16N2O5Purity:99% - 99.82%Color and Shape:SolidMolecular weight:352.34
