HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Products of "HIF/HIF Prolyl-Hydroxylase"
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KC7F2
CAS:KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.Formula:C16H16Cl4N2O4S4Purity:98% - 99.11%Color and Shape:SolidMolecular weight:570.38Angiogenesis agent 1
CAS:Compound C-31, a salidroside-based glycoside, activates HIF-1α and may aid in diabetic limb ischemia studies.Formula:C20H24O7Purity:98%Color and Shape:SolidMolecular weight:376.4(-)-Hydroxycitric acid lactone
CAS:(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, whichFormula:C6H6O7Purity:99.91%Color and Shape:SolidMolecular weight:190.11AKBA
CAS:AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.Formula:C32H48O5Purity:97.85% - 99.77%Color and Shape:SolidMolecular weight:512.72Ref: TM-T5S1569
1g1,863.00€1mg43.00€5mg88.00€10mg117.00€25mg187.00€50mg279.00€100mg439.00€500mg1,188.00€1mL*10mM (DMSO)143.00€Adaptaquin
CAS:Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].Formula:C21H16ClN3O2Purity:98.35%Color and Shape:SolidMolecular weight:377.82PHD2-IN-4
CAS:PHD2-IN-4 (compound 1) is an inhibitor of PHD2, with an IC50 of 4 nM. It is utilized in research related to chronic kidney disease.Formula:C21H19N5O3Color and Shape:SolidMolecular weight:389.407TM6089
CAS:TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.Formula:C13H14N4O3SPurity:99.07%Color and Shape:SolidMolecular weight:306.34Ref: TM-T17105
1mg74.00€5mg164.00€10mg239.00€25mg430.00€50mg645.00€100mg940.00€200mg1,264.00€1mL*10mM (DMSO)170.00€Oltipraz
CAS:Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties.Formula:C8H6N2S3Purity:100% - 99.56%Color and Shape:SolidMolecular weight:226.34UNC6934
CAS:UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.Formula:C24H21N5O4Purity:99.81%Color and Shape:SolidMolecular weight:443.45Ref: TM-T9584
1mg86.00€2mg111.00€5mg180.00€10mg283.00€25mg455.00€50mg645.00€100mg882.00€500mg1,758.00€1mL*10mM (DMSO)188.00€Annaosanchun
CAS:Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).Formula:C19H32O3Purity:99.58%Color and Shape:SolidMolecular weight:308.46AFP464 free base
CAS:AFP464 (NSC710464) free base is an active HIF-1α inhibitor (IC50: 0.25 μM) and a potent aryl hydrocarbon receptor (AhR) activator.Formula:C22H23F3N4O3Purity:98%Color and Shape:SolidMolecular weight:448.44PHD-1-IN-1
CAS:PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).Formula:C13H8N4Purity:99.78%Color and Shape:SolidMolecular weight:220.23Daprodustat
CAS:Daprodustat (GSK1278863) is a HIF-prolyl hydroxylase inhibitor.Formula:C19H27N3O6Purity:97% - 99.82%Color and Shape:SolidMolecular weight:393.43Ref: TM-T3197
1mg39.00€5mg75.00€10mg111.00€25mg177.00€50mg296.00€100mg439.00€200mg645.00€1mL*10mM (DMSO)90.00€B2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFormula:C20H17ClN4O3Purity:99.14%Color and Shape:SolidMolecular weight:396.83PX-478
CAS:PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability.Formula:C13H20Cl4N2O3Purity:97% - ≥98%Color and Shape:SolidMolecular weight:394.12FG-2216
CAS:FG-2216 (YM-311) is a HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme; orally bioavailable and induced reversible and significant Epo induction in vivo.Formula:C12H9ClN2O4Purity:100% - 99%Color and Shape:SolidMolecular weight:280.66
