HIF/HIF Prolyl-Hydroxylase
Hypoxia-Inducible Factor (HIF) is a transcription factor that plays a critical role in cellular responses to low oxygen levels (hypoxia). HIF activity is tightly regulated by HIF prolyl-hydroxylases, which target HIF for degradation under normoxic conditions. Inhibitors of HIF prolyl-hydroxylase can stabilize HIF, promoting the expression of genes involved in angiogenesis, erythropoiesis, and metabolism. These inhibitors are of great interest in treating conditions such as anemia, ischemic diseases, and cancer. At CymitQuimica, we offer HIF/HIF prolyl-hydroxylase inhibitors to support your research in hypoxia biology, cancer therapy, and metabolic regulation.
Products of "HIF/HIF Prolyl-Hydroxylase"
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KRH102140
CAS:KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.Formula:C25H24FNOPurity:98.31% - 99.61%Color and Shape:SolidMolecular weight:373.46Glucosamine
CAS:Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids.Formula:C6H13NO5Purity:99.80% - 99.80%Color and Shape:CoaMolecular weight:179.17Vadadustat
CAS:Vadadustat is a novel, titratable, oral hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor in development for the treatment of anemia.Formula:C14H11ClN2O4Purity:99.09% - 99.4%Color and Shape:SolidMolecular weight:306.7ZG-2033
CAS:ZG-2033 (Compound 26) is an orally active HIF-2α agonist that exhibits nanomolar activity (EC50 = 490 nM) in a luciferase reporter assay. It demonstrates an anti-anemic effect and shows synergistic effects with AKB-6548 in anemia, making it useful for the study of renal anemia.Formula:C15H14N2O2SColor and Shape:SolidMolecular weight:286.35Sirtuin modulator 2
CAS:Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.Formula:C19H15N3O2SPurity:99.47%Color and Shape:SolidMolecular weight:349.41Glucosamine hydrochloride
CAS:Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.Formula:C6H13NO5·HClPurity:99.77%Color and Shape:White Solid CrystallineMolecular weight:215.63HIF-1α-IN-6
HIF-1α-IN-6 (compound 3s) is a potent inhibitor of HIF-1α, demonstrating IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively.Purity:98%Color and Shape:Odour SolidAmifostine
CAS:Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.Formula:C5H15N2O3PSPurity:99.88%Color and Shape:White SolidMolecular weight:214.22BAY 87-2243
CAS:BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).Formula:C26H26F3N7O2Purity:98% - 99.77%Color and Shape:SolidMolecular weight:525.53M1002
CAS:M1002, a HIF-2 agonist, boosts HIF-2alpha/ARNT activation and alters HIF-281alpha PAS-B, working with PHD inhibitors.Formula:C15H8F6N2O2SPurity:99.73%Color and Shape:SolidMolecular weight:394.29Ref: TM-T61822
1mg52.00€5mg97.00€10mg153.00€25mg249.00€50mg369.00€100mg545.00€500mg1,130.00€1mL*10mM (DMSO)114.00€ZINC13466751
CAS:ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).Formula:C20H21N5O2Purity:99.94%Color and Shape:SolidMolecular weight:363.41Ref: TM-T13398
1mg48.00€5mg97.00€10mg160.00€25mg255.00€50mg353.00€100mg452.00€200mg630.00€1mL*10mM (DMSO)105.00€HIF-2α-IN-4
CAS:HIF-2a translation inhibitor is a compound used as a molecular building block.Formula:C9H9N3O4S2Purity:≥98%Color and Shape:SolidMolecular weight:287.32ZG-2305
ZG-2305 is an effective, selective, and orally active inhibitor of FIH (factor inhibiting hypoxia-inducible factor (FIH)), with Ki values of 79.6 nM for FIH and 2786 nM for PHD2. This compound enhances the expression of the EGLN3 gene, reduces cellular triglyceride levels, and decreases lipid accumulation. ZG-2305 holds potential for research into obesity and fatty liver disease.Formula:C17H11Cl2N3O5Color and Shape:SolidMolecular weight:408.19HIF-IN-1
CAS:HIF-IN-1 is a inhibitor of hypoxia-inducible factor, which is associated with tumor and cancer cell proliferation and inhibits HIF-1α protein aggregation.Formula:C17H12N2OPurity:99.48%Color and Shape:SolidMolecular weight:260.29ENMD-1198
CAS:ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.Formula:C20H25NO2Purity:98%Color and Shape:SolidMolecular weight:311.42HIF-1α-IN-2 hydrochloride
HIF-1α-IN-2 hydrochloride is a potent HIF-1α inhibitor exhibiting anticancer activity, demonstrated by IC50 values of 28 nM in MDA-MB-231 cells and 15 nM inFormula:C21H20ClN3OSPurity:98%Color and Shape:SolidMolecular weight:397.92E3330
CAS:E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.Formula:C21H30O6Purity:98.83%Color and Shape:SolidMolecular weight:378.46Ref: TM-T6823
1mg50.00€2mg72.00€5mg107.00€10mg167.00€25mg304.00€50mg500.00€100mg725.00€200mg1,017.00€500mg1,510.00€1mL*10mM (DMSO)88.00€IMM-H007
CAS:IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expressionFormula:C22H23N5O8Purity:97.73%Color and Shape:SolidMolecular weight:485.45Ref: TM-T9010
1mg40.00€5mg96.00€10mg135.00€25mg226.00€50mg320.00€100mg434.00€200mg602.00€1mL*10mM (DMSO)131.00€PHD2-IN-1
CAS:PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].Formula:C21H23ClN4O5Purity:98%Color and Shape:SolidMolecular weight:446.88
