PPAR
Peroxisome Proliferator-Activated Receptors (PPARs) are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes involved in metabolism, particularly fatty acid storage and glucose metabolism. PPAR inhibitors are important tools for studying metabolic disorders such as diabetes, obesity, and cardiovascular diseases. These inhibitors can modulate lipid metabolism, insulin sensitivity, and inflammation, making them valuable in therapeutic research. At CymitQuimica, we offer a range of PPAR inhibitors to support your research in metabolic diseases, endocrinology, and drug development.
Products of "PPAR"
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Oleuropein
CAS:Oleuropein is an antioxidant polyphenol isolated from olive leaf.Formula:C25H32O13Purity:98% - 99.95%Color and Shape:Brown PowderMolecular weight:540.51PPARγ agonist 15
PPARγ agonist15 (Compound 7c) functions as an agonist of PPARγ, inhibiting the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 values of 28.35 µM and 26.21 µM, respectively. It enhances glucose uptake in L6 myotubes and improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat model of Streptozotocin-induced diabetes.Formula:C21H16N4O3S2Color and Shape:SolidMolecular weight:436.51MCC-555
CAS:MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.Formula:C21H16FNO3SPurity:98.56% - 99.07%Color and Shape:SolidMolecular weight:381.42Ref: TM-T21764
5mg70.00€10mg111.00€25mg226.00€50mg376.00€100mg560.00€500mg1,216.00€1mL*10mM (DMSO)77.00€Ragaglitazar
CAS:Ragaglitazar(NNC-61-0029) is a potent dual activator of PPARγ and PPARα.Cost-effective and quality-assured.Formula:C25H25NO5Purity:98.95% - 99.33%Color and Shape:SolidMolecular weight:419.47PPARγ-IN-5
CAS:PPARγ-IN-5 (Compound A3) is an inhibitor of PPARγ. In liver cells, it reduces lipid accumulation and shows no significant cytotoxicity in HepG2 cells at a concentration of 400 µM. PPARγ-IN-5 is applicable for research on non-alcoholic fatty liver disease.Formula:C22H23ClO7Color and Shape:SolidMolecular weight:434.867Astaxanthin
CAS:Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.Formula:C40H52O4Purity:95.1% - 99.79%Color and Shape:Needles From Acetone/Light Petroleum SolidMolecular weight:596.84E0924G
CAS:E0924G is an orally active PPARδ agonist with an EC50 of 2.82 μM. It enhances the upregulation of osteoprotegerin (OPG) expression, with an EC50 of 0.29 μM. E0924G reduces RANKL-induced osteoclast differentiation and inhibits F-actin ring formation in RAW264.7 macrophages. Additionally, E0924G modulates bone density and bone loss in models of ovariectomy (OVX) and age-related osteoporosis.Formula:C12H12N2O3Color and Shape:SolidMolecular weight:232.24(±)4-HDHA
CAS:(±)4-HDHA is an autoxidation product of docosahexaenoic acid (DHA) in vitro.Formula:C22H32O3Purity:99.05%Color and Shape:SolidMolecular weight:344.49Ref: TM-T36602
1mg1,539.00€5mg3,087.00€10mg4,170.00€25mg6,194.00€25μg (2.90mM*25μL in MeOH)160.00€50μg (2.90mM*50μL in MeOH)283.00€100μg (2.90mM*100μL in MeOH)538.00€GSK3787
CAS:GSK3787 is a specific and irreversible PPARδ inhibitor(pIC50= 6.6).Formula:C15H12ClF3N2O3SPurity:98% - 98.53%Color and Shape:SolidMolecular weight:392.78Ref: TM-T1941
5mg55.00€10mg87.00€25mg173.00€50mg309.00€100mg520.00€500mg1,111.00€1mL*10mM (DMSO)55.00€Pirinixic Acid
CAS:Pirinixic Acid (NSC 310038) is a synthetic thiacetic acid derivative used in biomedical research, a peroxisome proliferator that activates specific PPAR.Formula:C14H14ClN3O2SPurity:98.27% - 99.92%Color and Shape:SolidMolecular weight:323.8Ref: TM-T2269
1g350.00€10mg48.00€25mg64.00€50mg79.00€100mg105.00€200mg148.00€500mg236.00€1mL*10mM (DMSO)47.00€Inolitazone
CAS:Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.Formula:C27H26N4O4SPurity:98.00% - 99.58%Color and Shape:SolidMolecular weight:502.58Ref: TM-T15581
1mg73.00€5mg158.00€10mg244.00€25mg394.00€50mg562.00€100mg753.00€500mgTo inquire1mL*10mM (DMSO)188.00€Furegrelate
CAS:FUREGRELATE, a thromboxane A2 (TxA2) synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets.Formula:C15H11NO3Purity:100%Color and Shape:SolidMolecular weight:253.25Ref: TM-T11339L
1mg115.00€5mg249.00€10mg369.00€25mg562.00€50mg787.00€100mg1,054.00€200mg1,406.00€1mL*10mM (DMSO)226.00€Linotroban
CAS:Linotroban(CL-871502) is a potent selective thromboxane (TXA2) receptor antagonist with antithrombotic activity.Formula:C14H15NO5S2Purity:100% - 99.31%Color and Shape:SolidMolecular weight:341.4GW 501516
CAS:GW 501516 (Endurobol) is a effective and highly specifc PPARβ/δ agonist (EC50: 1 nM), with 1000-fold selectivity over hPPARα/γ.Formula:C21H18F3NO3S2Purity:98.91% - 99.64%Color and Shape:White SolidMolecular weight:453.5PPARα/δ agonist 3
CAS:PPARα/δ agonist 3 (Compound 8) is an orally active PPAR agonist capable of activating PPARα, PPARδ, and PPARγ, with EC50 values of 5.6 nM, 3.4 nM, and 1278 nM, respectively. It exhibits anti-cholestatic activity in mouse models of cholestatic liver disease induced by ANIT or CDCA.Formula:C23H25F3N2O4Color and Shape:SolidMolecular weight:450.451LJ570
CAS:LJ570 is the first PPARα/γ dual agonist (PPARα,PPARγ with EC50s of 1.05 and 0.12 μM, respectively[)Formula:C27H22O3Purity:99.64%Color and Shape:SolidMolecular weight:394.46Ref: TM-T8374
1mg145.00€2mg213.00€5mg329.00€10mg470.00€25mg718.00€50mg938.00€100mg1,301.00€500mg2,612.00€1mL*10mM (DMSO)354.00€NPC 15199
CAS:NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.Formula:C21H23NO4Purity:99.94%Color and Shape:White Crystalline PowderMolecular weight:353.41Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Formula:C37H46O12Purity:99.06% - ≥95%Color and Shape:SolidMolecular weight:682.75Daidzein
CAS:Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein.Formula:C15H10O4Purity:98.08%Color and Shape:SolidMolecular weight:254.24Foenumoside B
CAS:Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotesFormula:C60H96O25Purity:98%Color and Shape:SolidMolecular weight:1217.39
