Antiparasitics

Levamisole is a synthetic imidazothiazole derivative belonging to the family of anthelmintic drugs. It is a nicotinic acetylcholine receptor (nAChR) agonists that binds to nAChRs on the neuromuscular junctions of parasitic worms, mimicking the action of the neurotransmitter acetylcholine. This excessive stimulation of nAChRs leads to persistent depolarization of muscle cells and spastic paralysis to expel of the worms. Levamisole exhibits broad-spectrum activity against various roundworms, whipworms, hookworms, and threadworms. Levamisole HCl is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Proguanil hydrochloride, a biguanide, metabolizes into cycloguanil, an anti-malaria agent that inhibits plasmodium's DNA and protein synthesis.

Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)

Applications A labelled Chloroquine metabolite, also an intermediate in the preparation of labelled Chloroquine It is a COVID19-related research product. References Brown, N., et al.: J. Chromatogr., Biomed. App., 309, 426 (1984), Nord, K., et al.: Int. J. Pharm., 72, 11 (1991),

Piperazine adipate is a potent broad spectrum anthelmintic.

Compound 4b (antitrypanosomal agent 13) is a potent antitrypanosomal with notable trypanocidal and cytotoxic activities, exhibiting GI50 values of 0.18 μM

ABMA is a broad-spectrum inhibitor shielding cells from viruses, bacteria, and parasites, acting in late endosomes.

Antileishmanial agent-25 (compound 24) exhibits selective activity against intracellular amastigotes, demonstrating an inhibitory concentration (IC50) of 6.63

Compound 24 (Compound 7), an in vitro antimalarial agent, demonstrates inhibitory activity against the Plasmodium falciparum W2 strain with an IC50 of 0.81 μM

Cycloguanil hydrochloride, proguanil's metabolite, inhibits Plasmodium/human dihydrofolate reductase (Ki: 0.3/1.5 nM).

Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a derivative of quinine with antimicrobial activity against Streptococcus pneumoniae.

Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.

Amodiaquine dihydrochloride dihydrate (Amodiaquin hydrochloride) is an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory effects

Rufigallol, an anthraquinone with six OH groups, induces DLC and fluoresces when aggregated, showing antimalarial effects with vitamin C and ketones.

Imidocarb dipropionate is an antigenic insecticide, is active against the protozoan parasite B. bovis (IC50 : 0.87 μg/ml).

Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.

Applications An intermediate in the synthesis of the metabolite of Nitazoxanide. References Honma, K., et al.: Chem. Pharm. Bull., 24, 394 (1976), Dubreuil, L., et al.: Antimicrob. Agents Chemother., 40, 2266 (1996), Stockis, A., et al.: Int. J. Clin. Pharmacol. Ther., 34, 349 (1996),

Kukoamine A: anticancer, cytoprotective, antioxidant, anti-inflammatory, inhibits trypanothione reductase (mixed inhibitor, Ki=1.8µM).