TNF
Los inhibidores del factor de necrosis tumoral (TNF) son compuestos que bloquean la actividad del TNF, una citocina involucrada en la inflamación y la regulación de la apoptosis. El TNF puede inducir apoptosis en algunos tipos celulares mientras promueve la supervivencia y la inflamación en otros. Inhibir el TNF es crucial en el tratamiento de enfermedades autoinmunes, condiciones inflamatorias crónicas y ciertos tipos de cáncer. Los inhibidores de TNF ayudan a modular la respuesta inmunitaria y a reducir el daño tisular causado por la inflamación excesiva. En CymitQuimica, ofrecemos una amplia gama de inhibidores de TNF de alta calidad para apoyar su investigación en inmunología, inflamación y apoptosis.
Productos de "TNF"
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Tilogotamab
CAS:Tilogotamab (GEN-1029) is an agonistic hexameric complex targeting two independent epitopes on DR5, used for studying multiple myeloma (MM).Pureza:95%Forma y color:LiquidUCB-9260
CAS:UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.Fórmula:C26H25N5OPureza:98.39% - 99.24%Forma y color:SolidPeso molecular:423.51Trifolirhizin
CAS:Trifolirhizin exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, and therefore, are candidates as skin-whitening agents.Fórmula:C22H22O10Pureza:98% - 99.67%Forma y color:SolidPeso molecular:446.4HS-243
CAS:HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.Fórmula:C17H16N4O3Pureza:97.34%Forma y color:SolidPeso molecular:324.33Varlilumab
CAS:Varlilumab (CDX-1127) is a novel human IgG1 anti-CD27 monoclonal antibody. Varlilumab has antitumor activity and can be used to study advanced solid tumors.Pureza:SDS-PAGE:95% SEC-HPLC:98.65%Forma y color:LiquidPeso molecular:146 kDaUCB-5307
CAS:UCB-5307 inhibits TNFR1, binds TNFα with 9 nM KD, shows slow kinetics (KD=6 nM), and penetrates hTNF/hTNFR1 complexes.Fórmula:C22H21N3OPureza:98.02%Forma y color:SolidPeso molecular:343.42LASSBio-1135
CAS:LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.Fórmula:C18H14N4Pureza:99.09%Forma y color:SolidPeso molecular:286.33C 87
CAS:C 87: Small-molecule TNF-α inhibitor, binds TNFα, inhibits cytotoxicity with IC50 of 8.73 μM, blocks signaling.Fórmula:C24H15ClN6O3SPureza:≥98%Forma y color:SolidPeso molecular:502.93Cot inhibitor-2
CAS:Cot inhibitor-2: Potent, selective Tpl2/MAP3K8 blocker. IC50: 1.6 nM; hampers LPS-induced TNF-α, IC50: 0.3 μM. Orally active.Fórmula:C26H25Cl2FN8Pureza:98.87%Forma y color:SolidPeso molecular:539.43Ref: TM-T10866
1mg74,00€5mg165,00€10mg255,00€25mg537,00€50mg753,00€100mg1.074,00€200mg1.444,00€1mL*10mM (DMSO)190,00€Belimumab
CAS:Belimumab, a human IgG1λ monoclonal antibody, blocks BAFF, treating lupus and related fatigue.Pureza:SDS-PAGE:98.4%;SEC-HPLC:98.4%Forma y color:LiquidPeso molecular:144.07 kDaRuplizumab
CAS:PF-03732010 is a humanized antibody targeting P-calmodulin with antitumor and antimetastatic activity.Pureza:95% - 95%Forma y color:LiquidCot inhibitor-1
CAS:Cot inhibitor-1 selectively blocks Tpl2 kinase, reducing TNF-alpha in blood (IC50: 5.7 nM). It may treat arthritis, IBD, and certain cancers.Fórmula:C27H27Cl2FN8Pureza:99.19%Forma y color:SolidPeso molecular:553.46Ref: TM-T10865
1mg81,00€5mg169,00€10mg246,00€25mg445,00€50mg655,00€100mg998,00€200mg1.349,00€1mL*10mM (DMSO)197,00€Dapirolizumab
Dapirolizumab is an anti-CD40 monoclonal antibody used in research on systemic lupus erythematosus (SLE) and other autoimmune diseases.Forma y color:LiquidPeso molecular:145.5 kDaBMS-561392
CAS:BMS-561392 (DPC333) is a tumor necrosis factor-α ( TNF-α) Invertase inhibitor.Fórmula:C27H32N4O4Pureza:99.16%Forma y color:SolidPeso molecular:476.57Siegeskaurolic acid
CAS:Siegeskaurolic acid reduces inflammation and pain by blocking iNOS and COX-2 in macrophages via NF-kappaB inactivation.Fórmula:C20H32O3Pureza:98%Forma y color:SolidPeso molecular:320.47Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.12%Forma y color:SolidPeso molecular:512.46Neochlorogenic acid
CAS:Neochlorogenic acid (trans-5-O-Caffeoylquinic acid) is an antioxidant compound used in the treatment of oxidative stress and related afflictions.Fórmula:C16H18O9Pureza:99.12% - 99.73%Forma y color:White PowderPeso molecular:354.31Hispidol
CAS:Hispidol ((Z)-Hispidol) ((Z)-Hispidol) is a potential therapeutic for inflammatory bowel disease; inhibits TNF-α induced adhesion of monocytes to colonFórmula:C15H10O4Pureza:97.86% - 98.45%Forma y color:SolidPeso molecular:254.24Ref: TM-T4319
1mg44,00€2mg59,00€5mg87,00€10mg144,00€25mg212,00€50mg274,00€100mg432,00€200mg590,00€500mg1.008,00€1mL*10mM (DMSO)97,00€α-Humulene
CAS:α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatoryFórmula:C15H24Pureza:97.18% - 97.18%Forma y color:LiquidPeso molecular:204.35RO7567132
RO7567132 is a bispecific antibody that binds and agonizes LTBR bivalently while binds and antagonizes FAP monovalently, inducing the formation of local TLS.Forma y color:Odour Liquid
