Sirtuin
Las sirtuinas son una familia de desacetilasas dependientes de NAD+ que desempeñan un papel crucial en la regulación de procesos celulares como la reparación del ADN, el envejecimiento, el metabolismo y la resistencia al estrés. Las sirtuinas influyen en la reparación del ADN desacetilando proteínas involucradas en las vías de reparación, modulando así su actividad. Los inhibidores y activadores de sirtuinas son herramientas valiosas en la investigación sobre el envejecimiento, el cáncer y las enfermedades metabólicas, donde la regulación de la reparación del ADN y la longevidad celular es de interés. En CymitQuimica, ofrecemos una gama de moduladores de sirtuinas de alta calidad para apoyar su investigación en reparación del ADN, envejecimiento celular y regulación metabólica.
Productos de "Sirtuin"
Ordenar por
Resveratrol
CAS:Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities.Fórmula:C14H12O3Pureza:99.53% - 99.9%Forma y color:Off-White To Tan PowderPeso molecular:228.24Agrimol B
CAS:1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.Fórmula:C37H46O12Pureza:99.06% - ≥95%Forma y color:SolidPeso molecular:682.753-TYP
CAS:3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor.Fórmula:C7H6N4Pureza:100% - 99.16%Forma y color:SolidPeso molecular:146.15Ref: TM-T4108
5mg57,00€10mg87,00€25mg170,00€50mg261,00€100mg470,00€500mg1.064,00€1mL*10mM (DMSO)57,00€OSS_128167
CAS:OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).Fórmula:C19H14N2O6Pureza:97.47% - 99.25%Forma y color:SolidPeso molecular:366.32Ref: TM-T4328
1mg46,00€2mg59,00€5mg93,00€10mg117,00€25mg235,00€50mg432,00€100mg638,00€500mg1.359,00€1mL*10mM (DMSO)93,00€MC2184
CAS:MC2184 is the inhibitor of human recombinant SIRT1.Fórmula:C11H6N2O3Pureza:98%Forma y color:SolidPeso molecular:214.18MDL-800
CAS:MDL-800 is a SIRT6 modulator with antitumor activity for the study of hepatocellular carcinoma and non-small cell lung cancer.Fórmula:C21H16BrCl2FN2O6S2Pureza:100%Forma y color:SolidPeso molecular:626.3BML-278
CAS:BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, andFórmula:C24H25NO4Pureza:100%Forma y color:SolidPeso molecular:391.46Selisistat S-enantiomer
CAS:Selisistat S-enantiomer (EX-527 S-enantiomer) is an effective and specific SIRT1 inhibitor (IC50 = 98 nM) and shows >200-fold selectivity against SIRT2/3.Fórmula:C13H13ClN2OPureza:99.69%Forma y color:SolidPeso molecular:248.71Ref: TM-T7058
1mg150,00€2mg215,00€5mg331,00€10mg472,00€25mg753,00€50mg1.074,00€1mL*10mM (DMSO)379,00€CAY10602
CAS:CAY10602 activates SIRT1, suppresses NF-κB/TNF-α in THP-1 cells with 75% efficacy at 60 μM, non-toxic.Fórmula:C22H15FN4O2SPureza:98.92%Forma y color:SolidPeso molecular:418.44SIRT-IN-2
CAS:SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).Fórmula:C15H21N5O3S2Pureza:98.26%Forma y color:SolidPeso molecular:383.49Ref: TM-T12919
1mg97,00€5mg227,00€10mg364,00€25mg620,00€50mg848,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)250,00€MC3482
CAS:MC3482 is a specific inhibitor of sirtuin5 (SIRT5).Fórmula:C33H38N4O8Pureza:98% - 99.48%Forma y color:SoildPeso molecular:618.68Ref: TM-T11962
1mg52,00€2mg74,00€5mg111,00€10mg180,00€25mg283,00€50mg445,00€100mg723,00€500mg1.454,00€SIRT5 inhibitor 5
CAS:SIRT5 Inhibitor 5 is a potent substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 0.21 µM, and does not interact with the NAD+-binding pocket [1].Fórmula:C21H14ClN3O3SPureza:98%Forma y color:SolidPeso molecular:423.87UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Fórmula:C16H13N3Pureza:99.75%Forma y color:SolidPeso molecular:247.29Ref: TM-T7679
1mg40,00€5mg81,00€10mg116,00€25mg226,00€50mg324,00€100mg452,00€200mg632,00€1mL*10mM (DMSO)100,00€Nicotinamide riboside
CAS:Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-Fórmula:C11H15N2O5Pureza:98.61% - 99.58%Forma y color:SolidPeso molecular:255.25Salermide
CAS:Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.Fórmula:C26H22N2O2Pureza:97.09% - 99.55%Forma y color:SolidPeso molecular:394.47SIRT7 inhibitor 97491
CAS:SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.Fórmula:C15H12ClN3OPureza:99.79%Forma y color:SolidPeso molecular:285.73Ref: TM-T39233
1mg96,00€5mg235,00€10mg354,00€25mg597,00€50mg852,00€100mg1.159,00€1mL*10mM (DMSO)259,00€SIRT6 activator 2
CAS:SIRT6 activator2 (compound 31) is a sirtuin6 activator known for its anti-lipid accumulation properties. It significantly downregulates LXR, SREBP-1c, and their target genes, making it valuable for research into lipid metabolism-related diseases.Fórmula:C23H23N3O6Forma y color:SolidPeso molecular:437.45Ganoderic acid D
CAS:Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.Fórmula:C30H42O7Pureza:98.06% - 99.87%Forma y color:SolidPeso molecular:514.65AGK2
CAS:AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.Fórmula:C23H13Cl2N3O2Pureza:98.68% - 99.17%Forma y color:SolidPeso molecular:434.27SIRT2-IN-9
CAS:SIRT2-IN-9: selective SIRT2 inhibitor; IC50=1.3μM; halts MCF-7 cell growth; for cancer study.Fórmula:C21H22N6OS2Pureza:99.5%Forma y color:SolidPeso molecular:438.57
