Sirtuin
Las sirtuinas son una familia de desacetilasas dependientes de NAD+ que desempeñan un papel crucial en la regulación de procesos celulares como la reparación del ADN, el envejecimiento, el metabolismo y la resistencia al estrés. Las sirtuinas influyen en la reparación del ADN desacetilando proteínas involucradas en las vías de reparación, modulando así su actividad. Los inhibidores y activadores de sirtuinas son herramientas valiosas en la investigación sobre el envejecimiento, el cáncer y las enfermedades metabólicas, donde la regulación de la reparación del ADN y la longevidad celular es de interés. En CymitQuimica, ofrecemos una gama de moduladores de sirtuinas de alta calidad para apoyar su investigación en reparación del ADN, envejecimiento celular y regulación metabólica.
Productos de "Sirtuin"
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SRT 1460
CAS:SRT 1460 is a SIRT1 activator.Fórmula:C26H29N5O4SPureza:98.25%Forma y color:SolidPeso molecular:507.6Et-29
CAS:Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.Fórmula:C34H46N6O6SPureza:98.69%Forma y color:SolidPeso molecular:666.83Sirt1/2-IN-3
CAS:Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively.Fórmula:C17H14ClNO4SPureza:98%Forma y color:SolidPeso molecular:363.82SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Fórmula:C25H23N7OSPureza:98.84%Forma y color:SolidPeso molecular:469.56Selisistat R-enantiomer
CAS:Selisistat R-enantiomer (EX-527 (R-enantiomer)) is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).Fórmula:C13H13ClN2OPureza:99.78%Forma y color:SolidPeso molecular:248.71Ref: TM-T15263
1mg106,00€2mg159,00€5mg259,00€10mg376,00€25mg630,00€50mg880,00€100mg1.169,00€1mL*10mM (DMSO)284,00€Dihydrocoumarin
CAS:Dihydrocoumarin, in Melilotus, inhibits yeast Sir2p, human SIRT1 (IC50: 208μM), and SIRT2 (IC50: 295μM).Fórmula:C9H8O2Pureza:98.46%Forma y color:Leaflets Room Temperature (Ntp 1992)Peso molecular:148.16Sirt1/2-IN-2
CAS:Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively.Fórmula:C18H14N4O3S2Pureza:98%Forma y color:SolidPeso molecular:398.46SIRT6-IN-3
CAS:SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and promptsFórmula:C21H30Br3ClN6SPureza:98%Forma y color:SolidPeso molecular:673.73Sirtuin-IN-2
Sirtuin-IN-2 (compound 20) is an inhibitor of Sirtuin5, a key target in leukemia and breast cancer.Fórmula:C28H46N8O6SForma y color:SolidPeso molecular:622.78SIRT3 activator 2
SIRT3 activator2 (compound 2a) acts as an activator of SIRT3. It is presumed to bind directly with SIRT3 in SH-SY5Y cells, as inferred through thermal stability, facilitating the SIRT3-dependent clearance of α-Syn. Furthermore, SIRT3 activator2 enhances motor functions in Parkinsonian mice and dose-dependently prevents the loss of dopaminergic (DA) neurons in the substantia nigra.Fórmula:C22H24N2O9SForma y color:SolidPeso molecular:492.5Ginkgolide C
CAS:Ginkgolide C (BN-52022), a natural product, can enhance the cardiac function of rats in the body.Fórmula:C20H24O11Pureza:99.71% - 99.98%Forma y color:White PowderPeso molecular:440.4MC3138
CAS:MC3138 is a selective SIRT5 activator showing anti-tumor effects in PDAC cells.Fórmula:C25H25NO6Pureza:99.57%Forma y color:SolidPeso molecular:435.47Ref: TM-T88662
1mg52,00€5mg100,00€10mg156,00€25mg302,00€50mg492,00€100mg749,00€200mg999,00€1mL*10mM (DMSO)105,00€Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Fórmula:C20H17N3O2Pureza:99.1%Forma y color:SolidPeso molecular:331.37
