Sirtuin
Las sirtuinas son una familia de desacetilasas dependientes de NAD+ que desempeñan un papel crucial en la regulación de procesos celulares como la reparación del ADN, el envejecimiento, el metabolismo y la resistencia al estrés. Las sirtuinas influyen en la reparación del ADN desacetilando proteínas involucradas en las vías de reparación, modulando así su actividad. Los inhibidores y activadores de sirtuinas son herramientas valiosas en la investigación sobre el envejecimiento, el cáncer y las enfermedades metabólicas, donde la regulación de la reparación del ADN y la longevidad celular es de interés. En CymitQuimica, ofrecemos una gama de moduladores de sirtuinas de alta calidad para apoyar su investigación en reparación del ADN, envejecimiento celular y regulación metabólica.
Productos de "Sirtuin"
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SIRT2-IN-16
SIRT2-IN-16 (compound 17) is a SIRT2 inhibitor targeted at prostate-specific membrane antigen (PSMA).Fórmula:C55H91N9O15SForma y color:SolidPeso molecular:1150.43SIRT-IN-6
CAS:SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with an IC50 value of >50 μM. It shows potential as a research agent for studies involving metabolic disorders, inflammation, cancer, and neurodegenerative diseases.Fórmula:C7H4ClN3OSForma y color:SolidPeso molecular:213.644Thiomyristoyl
CAS:Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.Fórmula:C34H51N3O3SPureza:99.16%Forma y color:SolidPeso molecular:581.85Ref: TM-T3447
1mg57,00€2mg77,00€5mg96,00€10mg124,00€25mg227,00€50mg380,00€100mg567,00€1mL*10mM (DMSO)124,00€SIRT6-IN-5
CAS:SIRT6-IN-5: potent, selective SIRT6 inhibitor; IC50=34 μM; immunosuppressive, enhances chemo, boosts H3K9 acetylation, glucose uptake, curbs T-cell growth.Fórmula:C19H14N2O6Pureza:98.84%Forma y color:SolidPeso molecular:366.32E1231
CAS:E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.Fórmula:C21H21N3O3Pureza:98.45%Forma y color:SolidPeso molecular:363.41Ref: TM-T9106
1mg35,00€5mg73,00€10mg104,00€25mg207,00€50mg329,00€100mg475,00€500mg938,00€1mL*10mM (DMSO)89,00€Sirt2-IN-1
CAS:Sirt2-IN-1 is an inhibitor of sirtuin 2 (IC50 = 163 nM).Fórmula:C28H27N7O2S2Pureza:99.05% - 99.15%Forma y color:SolidPeso molecular:557.69Ref: TM-T12920
1mg105,00€5mg215,00€10mg340,00€25mg542,00€50mg735,00€100mg938,00€500mg1.882,00€1mL*10mM (DMSO)266,00€Sirt1/2-IN-4
Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (Fórmula:C21H20N4O3S2Pureza:98%Forma y color:SolidPeso molecular:440.54Fisetin
CAS:Fisetin belongs to a group of natural flavonols with anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. Cost effective and quality assured.Fórmula:C15H10O6Pureza:94.14% - 98.31%Forma y color:Yellow To Brown Crystalline PowderPeso molecular:286.24AGK7
CAS:AGK7 is an AGK2 control; it's a less selective SIRT2 inhibitor, with IC50s >5 μM for SIRT3, and >50 μM for SIRT1/2.Fórmula:C23H13Cl2N3O2Pureza:98.31%Forma y color:SolidPeso molecular:434.27SRT 2104
CAS:SRT 2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.Fórmula:C26H24N6O2S2Pureza:97.03% - 99.83%Forma y color:SolidPeso molecular:516.64Ref: TM-T6679
1g1.644,00€1mg46,00€5mg87,00€10mg131,00€25mg230,00€50mg378,00€100mg563,00€200mg805,00€500mg1.225,00€SIRT-IN-1
CAS:SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).Fórmula:C19H27N5O2SPureza:97.07%Forma y color:SolidPeso molecular:389.52ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Fórmula:C26H29I2NO3Pureza:99.23%Forma y color:SolidPeso molecular:657.32Tenovin-1
CAS:Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.Fórmula:C20H23N3O2SPureza:99.33%Forma y color:SolidPeso molecular:369.48SIRT5 inhibitor 7
CAS:SIRT5 inhibitor 7 (compound 58), a selective and substrate-competitive SIRT5 inhibitor, exhibits anti-inflammatory properties by modulating proteinFórmula:C28H32ClN7O3SPureza:99.77%Forma y color:SolidPeso molecular:582.12MDL-811
CAS:MDL-811, an allosteric activator of SIRT6, markedly enhances the deacetylation of histone H3 at lysine residues 9, 18, and 56 (H3K9Ac, H3K18Ac, and H3K56Ac),Fórmula:C25H25BrCl2FN3O5S2Pureza:98%Forma y color:SolidPeso molecular:681.42SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Fórmula:C18H23NO4Pureza:98%Forma y color:SolidPeso molecular:317.38Sirtuin modulator 1
CAS:Sirtuin modulator 1 (SRT3025 Hydrochloride) is a modulator of SIRT1 with EC1.5 of < 1 μM.Fórmula:C31H32ClN5O2S2Pureza:99.1%Forma y color:SolidPeso molecular:606.2SRT 1720 dihydrochloride
CAS:SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).Fórmula:C25H25Cl2N7OSPureza:98.43%Forma y color:SolidPeso molecular:542.48Sirtinol
CAS:Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).Fórmula:C26H22N2O2Pureza:99.52% - 99.96%Forma y color:SolidPeso molecular:394.47Ref: TM-T6671
2mg43,00€5mg58,00€10mg93,00€25mg178,00€50mg343,00€100mg509,00€500mg1.121,00€1mL*10mM (DMSO)58,00€AK-7
CAS:AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.Fórmula:C19H21BrN2O3SPureza:98.43% - 99.34%Forma y color:SolidPeso molecular:437.35Ref: TM-T5490
1mg37,00€2mg49,00€5mg74,00€10mg105,00€25mg187,00€50mg329,00€100mg540,00€1mL*10mM (DMSO)94,00€
