Sirtuin
Las sirtuinas son una familia de desacetilasas dependientes de NAD+ que desempeñan un papel crucial en la regulación de procesos celulares como la reparación del ADN, el envejecimiento, el metabolismo y la resistencia al estrés. Las sirtuinas influyen en la reparación del ADN desacetilando proteínas involucradas en las vías de reparación, modulando así su actividad. Los inhibidores y activadores de sirtuinas son herramientas valiosas en la investigación sobre el envejecimiento, el cáncer y las enfermedades metabólicas, donde la regulación de la reparación del ADN y la longevidad celular es de interés. En CymitQuimica, ofrecemos una gama de moduladores de sirtuinas de alta calidad para apoyar su investigación en reparación del ADN, envejecimiento celular y regulación metabólica.
Productos de "Sirtuin"
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Nicotinamide riboside chloride
CAS:NR, also SRT647, is a B3 vitamin form; precursor to NAD+.Fórmula:C11H15ClN2O5Pureza:98.92% - 99.86%Forma y color:SolidPeso molecular:290.7Scopolin
CAS:Scopolin, a PAL-activity-induced compound, may alleviate rat AIA symptoms by curbing inflammation and angiogenesis, offering a basis for new drugs.Fórmula:C16H18O9Pureza:99.09% - ≥95%Forma y color:SolidPeso molecular:354.31Tenovin-3
CAS:Tenovin-3 acts as a p53 activator.Fórmula:C18H21N3OSPureza:100% - ≥95%Forma y color:SolidPeso molecular:327.44Ref: TM-T1873
1mg60,00€5mg126,00€10mg202,00€25mg432,00€50mg638,00€100mg908,00€500mg1.825,00€1mL*10mM (DMSO)140,00€Inauhzin
CAS:Inauhzin (INZ) reactivates p53, inhibits SIRT1, induces Y cell apoptosis without genotoxic stress (IC50=3 uM in A549).Fórmula:C25H19N5OS2Pureza:97.69% - 99.36%Forma y color:SolidPeso molecular:469.58Benzamide, 3-methoxy-N-(3-thiazolo[5,4-b]pyridin-2-ylphenyl)
CAS:3-Methoxybenzamide derivative modulates sirtuins; may boost cell lifespan and treat diseases.Fórmula:C20H15N3O2SPureza:99.02%Forma y color:SolidPeso molecular:361.42SRT 2183
CAS:SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).Fórmula:C27H24N4O2SPureza:97.86%Forma y color:SolidPeso molecular:468.57Ref: TM-T16932
1mg50,00€2mg72,00€5mg107,00€10mg165,00€25mg283,00€50mg430,00€100mg622,00€1mL*10mM (DMSO)111,00€SJ-106C
SJ-106C, a SIRT inhibitor, exhibits IC50 values of 0.59, 0.12, and 0.49 μM against SIRT1/2/3, respectively. This compound specifically targets mitochondria and inhibits the growth of DLBCL tumors.Forma y color:Odour SolidB2
CAS:B2 (Linazolamide intermediate B impurity 2) promotes inclusion formation in cellular models of Huntington's disease and Parkinson's diseaseFórmula:C20H17ClN4O3Pureza:99.14%Forma y color:SolidPeso molecular:396.83AK-1
CAS:AK-1: SIRT2 inhibitor, IC50 12.5 μM, hinders Alzheimer's neurodegeneration, arrests colon cancer cell cycle.Fórmula:C19H21N3O5SPureza:98.32% - 99.44%Forma y color:SolidPeso molecular:403.45HSP70/SIRT2-IN-1
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2.Pureza:98%Forma y color:Odour SolidEpigenetic factor-IN-1
CAS:Epigenetic factor-IN-1 (40569Z) is an epigenetic factor inhibitor that exhibits potent binding affinity for SIRT7.Fórmula:C32H34FN5O6S2Pureza:98%Forma y color:SolidPeso molecular:667.77RK-9123016
CAS:RK-9123016 is a SIRT2 inhibitor.Fórmula:C16H18N6O3SPureza:100%Forma y color:SolidPeso molecular:374.424'-bromo-Resveratrol
CAS:4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)Fórmula:C14H11BrO2Pureza:99.00%Forma y color:SolidPeso molecular:291.14SIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Fórmula:C24H29ClN8O4SPureza:99.93%Forma y color:SolidPeso molecular:561.06SIRT5 inhibitor 1
CAS:SIRT5 inhibitor 1 targets human Sirtuin 5 deacylase, with an IC50 of 0.11 μM, linked to aging diseases.Fórmula:C31H39FN6O6S2Pureza:98.06%Forma y color:SolidPeso molecular:674.81Ref: TM-T12921
1mg145,00€2mg207,00€5mg354,00€10mg530,00€25mg934,00€50mg1.359,00€100mg1.825,00€1mL*10mM (DMSO)465,00€Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Fórmula:C25H35ClN4O2SPureza:99.36%Forma y color:SolidPeso molecular:491.09Ref: TM-T8480
1mg39,00€2mg51,00€5mg70,00€10mg88,00€25mg140,00€50mg226,00€100mg376,00€1mL*10mM (DMSO)73,00€Gardenia yellow
CAS:Gardenia yellow (Crocin I) has anti atherosclerosis and hypolipidemic effects.Fórmula:C44H64O24Pureza:98.24% - 98.82%Forma y color:Orange Yellow To Reddish Yellow PowderPeso molecular:976.96Z26395438
CAS:Z26395438 is an inhibitor of Sirtuin-1 with IC50 of 1.6 μM.Fórmula:C17H15FN2OPureza:99.63%Forma y color:SolidPeso molecular:282.31Ref: TM-T77653
1mg57,00€2mg81,00€5mg120,00€10mg180,00€25mg329,00€50mg472,00€100mg700,00€500mg1.406,00€WAY-323061
CAS:WAY-323061 is a SIRT2 inhibitor.Fórmula:C25H21N5O2SPureza:99.33%Forma y color:SolidPeso molecular:455.53SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Fórmula:C22H25ClN8O2SPureza:99.68%Forma y color:SolidPeso molecular:501
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