Ras
Las proteínas Ras son pequeñas GTPasas que actúan como interruptores moleculares en la vía de señalización MAPK, controlando el crecimiento, la diferenciación y la supervivencia celular. Ras activado inicia una cascada de señalización que incluye Raf, MEK y ERK, lo que lleva a diversas respuestas celulares. Las mutaciones en los genes Ras son comunes en el cáncer, lo que convierte a Ras en un enfoque importante de la investigación oncológica. En CymitQuimica, ofrecemos una gama de moduladores de Ras para apoyar su investigación en biología del cáncer, transducción de señales y desarrollo terapéutico.
Productos de "Ras"
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pan-KRAS degrader 1
CAS:Pan-KRAS degrader 1 (Compound 1) is a broad-spectrum KRAS degrader, exhibiting an inhibitory constant Ki value of 25 nM against KRASG12V as determined by surface plasmon resonance (SPR). Additionally, this compound demonstrates antitumor activity.Fórmula:C22H26N8OSForma y color:SolidPeso molecular:450.56BQU57
CAS:BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.Fórmula:C16H13F3N4OPureza:97.45% - 98.72%Forma y color:SolidPeso molecular:334.3CCG-100602
CAS:CCG-100602 inhibits RhoA/C-mediated, SRF-driven luciferase expression in PC-3 prostate cancer cells (IC50 :9.8 μM).Fórmula:C21H17ClF6N2O2Pureza:99.58%Forma y color:SolidPeso molecular:478.82Ref: TM-T22062
5mg38,00€10mg57,00€25mg114,00€50mg188,00€100mg303,00€200mg449,00€1mL*10mM (DMSO)43,00€KRAS inhibitor-31
CAS:KRAS inhibitor-31 (compound 33), a potent agent targeting KRAS, exhibits K D (SPR) values of 0.019 nM for KRas G12D, 0.019 nM for KRas G12C, and 0.096 nM for KRas G12V, illustrating its efficacy across these variants.Fórmula:C33H30F3N5O4Forma y color:SolidPeso molecular:617.62CCG-203971
CAS:CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM.Fórmula:C23H21ClN2O3Pureza:98.82% - 99.35%Forma y color:SolidPeso molecular:408.88MC 976
CAS:MC 976 is a derivative of Vitamin D3.Fórmula:C27H42O3Pureza:98%Forma y color:SolidPeso molecular:414.63BI-3406
CAS:BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.Fórmula:C23H25F3N4O3Pureza:99.20% - 99.66%Forma y color:SolidPeso molecular:462.46Ref: TM-T12979
1mg73,00€5mg160,00€10mg250,00€25mg464,00€50mg663,00€100mg919,00€500mg1.833,00€1mL*10mM (DMSO)170,00€Ibetazol
Ibetazol is an inhibitor of importin β1 (KPNB1), which functions by binding to Cys585 of importin β1, thus preventing importin β1-mediated nuclear import with an EC50 of 6.1 µM.Fórmula:C13H11F3N2OSForma y color:SolidPeso molecular:300.3Methylophiopogonanone B
CAS:1. Methylophiopogonanone B (MOPB) induces cell morphological change and Rho activation via melanocyte dendrite retraction and stress fiber formation.Fórmula:C19H20O5Pureza:99.24%Forma y color:SolidPeso molecular:328.36ADT-007
CAS:ADT-007 is a pan-RAS inhibitor with potent anticancer activity.Fórmula:C26H24FNO5Pureza:97.75%Forma y color:SoildPeso molecular:449.47Ref: TM-T85316
1mg49,00€5mg92,00€10mg131,00€25mg212,00€50mg373,00€100mg635,00€200mg1.035,00€1mL*10mM (DMSO)110,00€Arglabin
CAS:Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.Fórmula:C15H18O3Pureza:99.62% - 99.62%Forma y color:SolidPeso molecular:246.3Ref: TM-TQ0165
1mg104,00€5mg240,00€10mg360,00€25mg520,00€50mg692,00€100mg1.035,00€1mL*10mM (DMSO)310,00€1-(4-methansulfinylphenyl)ethanone
CAS:The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.Fórmula:C9H10O2SPureza:99.48%Forma y color:SolidPeso molecular:182.24Ref: TM-T8870
1mg51,00€5mg153,00€10mg207,00€25mg288,00€50mg404,00€100mg562,00€200mg758,00€1mL*10mM (DMSO)101,00€KRas G12C inhibitor 3
CAS:KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.Fórmula:C32H36ClN7O2Pureza:98%Forma y color:SolidPeso molecular:586.13ARS-853
CAS:ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cellsFórmula:C22H29ClN4O3Pureza:96.64% - 97.43%Forma y color:SolidPeso molecular:432.94Ref: TM-T7414
1mg150,00€5mg373,00€10mg553,00€25mg890,00€50mg1.206,00€100mg1.634,00€500mg3.258,00€1mL*10mM (DMSO)356,00€KRAS inhibitor-35
CAS:KRAS inhibitor-35 (compound 72) is a KRAS inhibitor with an IC50 of 2 nM, utilized in tumor research.Fórmula:C38H32F4N6O3SForma y color:SolidPeso molecular:728.76pan-KRAS-IN-3
CAS:Pan-KRAS-IN-3 (Example 84) is a pan-KRAS inhibitor suitable for cancer research [1].Fórmula:C33H32F3N5O2Pureza:98%Forma y color:SolidPeso molecular:587.63KRAS G12D inhibitor 26
CAS:KRAS G12D inhibitor 26 serves as a modulator of Kras and specifically targets Kras(G12D) with an IC50 of less than or equal to 100 nM.Fórmula:C35H44ClFN8O2Forma y color:SolidPeso molecular:663.228CCG-1423
CAS:CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.Fórmula:C18H13ClF6N2O3Pureza:99.80%Forma y color:SolidPeso molecular:454.75CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Fórmula:C22H20BrN3O3SPureza:99.66%Forma y color:SolidPeso molecular:486.38Ref: TM-T8930
2mg35,00€5mg52,00€10mg89,00€25mg167,00€50mg258,00€100mg379,00€200mg540,00€1mL*10mM (DMSO)58,00€HJC0197
CAS:HJC0197 is a selective Epac antagonist; blocks cAMP-induced activation with IC50=5.9 μM for Epac2.Fórmula:C19H21N3OSPureza:98.05%Forma y color:SolidPeso molecular:339.45Ref: TM-T15485
2mg38,00€5mg54,00€10mg86,00€25mg135,00€50mg188,00€100mg283,00€200mg426,00€1mL*10mM (DMSO)64,00€
