Ubiquitinación
Los inhibidores de la ubiquitinación son compuestos que interfieren con el proceso de ubiquitinación, mediante el cual las proteínas son marcadas con moléculas de ubiquitina para su degradación por el proteasoma. Estos inhibidores son fundamentales para estudiar el recambio de proteínas, la transducción de señales y la regulación de diversos procesos celulares. La ubiquitinación juega un papel clave en muchas enfermedades, incluyendo el cáncer, los trastornos neurodegenerativos y las disfunciones del sistema inmunológico. Al modular la ubiquitinación, estos inhibidores pueden proporcionar información sobre los mecanismos de la enfermedad y abrir nuevas vías para la intervención terapéutica. En CymitQuimica, ofrecemos una amplia selección de inhibidores de ubiquitinación de alta calidad para apoyar su investigación en biología celular, proteómica y descubrimiento de fármacos.
Subcategorías de "Ubiquitinación"
Productos de "Ubiquitinación"
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BIO-2007817
BIO-2007817 is a positive allosteric modulator (PAM) of Parkin, an E3 ubiquitin ligase. This compound enhances the activity of wild-type Parkin, stimulates Parkin's autoubiquitination, and induces the appearance of mono-ubiquitinated forms of Miro1 (a Parkin substrate) with an EC50 of 0.17 μM.Fórmula:C32H36N6O3Forma y color:SolidPeso molecular:552.67Vialinin A
CAS:Vialinin A, a p-terphenyl with antioxidant properties, inhibits TNF-α/USP4/5/SENP1, used in autoimmune/cancer research.Fórmula:C34H26O8Pureza:99.89%Forma y color:SolidPeso molecular:562.57ZM223
CAS:ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).Fórmula:C23H17F3N4O2S2Pureza:99.67%Forma y color:SolidPeso molecular:502.53Ref: TM-T13412
1mg115,00€2mg172,00€5mg255,00€10mg374,00€25mg562,00€50mg787,00€100mg1.074,00€500mg2.147,00€USP7-797
CAS:USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Fórmula:C27H28ClN3O3SPureza:96.18%Forma y color:SolidPeso molecular:510.05Cbl-b-IN-7
CAS:Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50sFórmula:C29H31F4N5O2Pureza:98%Forma y color:SolidPeso molecular:557.58TAS4464
CAS:TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).Fórmula:C21H23FN6O6SPureza:98.27%Forma y color:SolidPeso molecular:506.51USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Fórmula:C17H16N6O2SPureza:100% - 96.31%Forma y color:SolidPeso molecular:368.41MID-1
CAS:MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.Fórmula:C12H11N3O4SPureza:99.39%Forma y color:SolidPeso molecular:293.3Ref: TM-T8773
1mg50,00€5mg97,00€10mg145,00€25mg259,00€50mg383,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)109,00€Cbl-b-IN-13
CAS:Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].Fórmula:C29H30F3N5O2Pureza:98%Forma y color:SolidPeso molecular:537.58Pevonedistat
CAS:Pevonedistat (MLN4924) is a potent and selective NEDD8 activating enzyme (NAE) inhibitor (IC50=4.7 nM).Fórmula:C21H25N5O4SPureza:95% - 99.92%Forma y color:SolidPeso molecular:443.52Ref: TM-T6332
1mg52,00€2mg70,00€5mg96,00€10mg144,00€25mg259,00€50mg424,00€100mg717,00€1mL*10mM (DMSO)94,00€USP8-IN-2
CAS:USP8-IN-2 is a potent inhibitor of the deubiquitinating enzymes USP7 and USP8, with an IC50 of 4.0 μM against USP8D.Fórmula:C19H20ClF3N4OSPureza:98.83%Forma y color:SolidPeso molecular:444.9Ref: TM-T67876
1mg88,00€5mg210,00€10mg329,00€25mg548,00€50mg782,00€100mg1.035,00€1mL*10mM (DMSO)245,00€Skp2 Inhibitor C1
CAS:Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.Fórmula:C18H13BrN2O4S2Pureza:100%Forma y color:SolidPeso molecular:465.34Ref: TM-T4253
2mg37,00€5mg55,00€10mg89,00€25mg167,00€50mg279,00€100mg408,00€200mg567,00€1mL*10mM (DMSO)57,00€DT204
CAS:DT204 is an SCFSkp2 inhibitor that reduces the binding of Skp2 to Cullin-1 and Commd1. It can be used to study multiple myeloma.Fórmula:C19H13BrClNO5SPureza:99.71%Forma y color:SolidPeso molecular:482.73LANOSTEROL
CAS:Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.Fórmula:C30H50OPureza:97.99% - 99.67%Forma y color:SolidPeso molecular:426.72NSC632839
CAS:NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2Fórmula:C21H22ClNOPureza:99.74% - 99.87%Forma y color:SolidPeso molecular:339.86USP7-IN-8
CAS:Benzamide, 4-[6-amino-4-ethyl-5-(4-hydroxyphenyl)-3-pyridinyl]-N-methyl- is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM.Fórmula:C21H21N3O2Pureza:99.31%Forma y color:SolidPeso molecular:347.41Ref: TM-T9217
1mg48,00€5mg97,00€10mg156,00€25mg284,00€50mg411,00€100mg562,00€200mg743,00€1mL*10mM (DMSO)105,00€TCID
CAS:TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.Fórmula:C9H2Cl4O2Pureza:99.34%Forma y color:SolidPeso molecular:283.92OTUB1/USP8-IN-1 HCl
OTUB1/USP8-IN-1 HCL is a potent dual inhibitor of OTUB1 and USP8 with potential antitumour activity, inhibiting both OTUB1 and USP8 for leukaemiaFórmula:C22H17Cl2FN2O4Pureza:99.90%Forma y color:SolidPeso molecular:463.29NSC697923
CAS:NSC-697923 inhibits UBE2N, triggers p53-dependent and JNK-mediated apoptosis, blocks DNA damage and NF-κB signaling in neuroblastoma cells.Fórmula:C11H9NO5SPureza:97% - 99.69%Forma y color:SolidPeso molecular:267.26Cbl-b-IN-26
CAS:Cbl-b-IN-26 (Example A1) is an inhibitor of Cbl-b with a dissociation constant (Kd) of 34.6 nM. It is used in the research of chronic viral infections and cancer.Fórmula:C21H19F3N6Forma y color:SolidPeso molecular:412.41
